Prevalence and description of disorders of gut-brain interaction in Spain according to the results of the Rome Foundation Global Epidemiology Study.

BACKGROUND: Data for Spain from the Rome Foundation Global Epidemiology Study on the disorders of gut-brain interaction (DGBI) were used to assess the national and regional prevalence of all 22 DGBI, the percentage of respondents meeting diagnostic criteria for at least one DGBI, and the impact on burden of disease in our country. METHODS: Data were collected through an anonymous, nationwide, and secure Internet survey with multiple built-in quality-assurance techniques that included the Rome IV diagnostic questionnaire and an in-depth supplemental questionnaire. KEY RESULTS: The survey was completed by 2072 adult Spanish participants (50.2% female) with a mean age of 45.67 ± 15.44 years with a good representative national distribution. 43.6% (41.5%-45.8%) met diagnostic criteria for at least one DGBI, with 8.2% for any esophageal disorder, 12.1% for any gastroduodenal disorder, 30.1% for any bowel disorder, and 11.5% for any anorectal disorder. Functional constipation was the most prevalent DGBI in Spain (12.8%). We found that proctalgia fugax (9.3%), unspecified bowel disorders (10.8%), and functional dysphagia (5.6%) showed unexplained high rates in our country. DGBI rates were higher for women. Having any DGBI was negatively associated with psychosocial variables (including quality of life, somatization, and concern about digestive problems), and associated with increased healthcare utilization. CONCLUSIONS & INFERENCES: We provide the first comprehensive data on the prevalence and burden of all DGBI in Spain using the Rome IV criteria. The enormous burden of DGBI in Spain highlights the need for specialized training and future research.

[Overlap of irritable bowel syndrome and functional dyspepsia based on Rome III criteria in medical students from a private university in Lima, Peru]. / Superposición del síndrome de intestino irritable y dispepsia funcional basados en criterios ROMA III en estudiantes de medicina de una universidad privada de Lima, Perú.

AIMS: To determine the prevalence of irritable bowel syndrome and functional dyspepsia in medical students from a private university in Lima, Peru. Furthermore, to determine the associated factors with these diseases. MATERIAL AND METHODS: Observational descriptive and retrospective cross sectional study. Medical students from a private university in Lima were surveyed using a Rome III questionnaire for functional disorders and the STEPwise auto survey for defining the variables of alcohol and tobacco. For data analysis the Stata 11.0 program was used. RESULTS: Of the 608 students, 543 answered the questionnaire. The prevalence of Irritable Bowel Syndrome was 12.4%, 16.9% of dyspepsia, and of both diseases simultaneously, a prevalence of 7.1% was found. Alcohol consumption in the total population was 89.4% and 29.0% of tobacco. Association between both disorders was found (OR 10.47, 95% CI 5.08 to 21.55; p < 0.001), dyspepsia was associated with sex (OR: 0.16, 95% CI 0.07 to 0.36 p < 0.001), with alcohol consumption (OR: 5.22, 95% CI 23.99 1,13- p = 0.034) and with irritable bowel syndrome (OR: 9.88, 95% CI 4.78 to 20.46 p <0.001). Both conditions together were associated with sex (OR: 0.20, 95% CI from 0.06 to 0.60 p = 0.004) and daily consumption of tobacco (OR: 3.23, 95% CI 1.17 to 8.89 p = 0.023). CONCLUSION: A prevalence of 12.4% of Irritable Bowel Syndrome and 16.9% of dyspepsia was determined. An overlap of 7.1% of these diseases was reported.

Superposición del síndrome de intestino irritable y dispepsia funcional basados en criterios ROMA III en estudiantes de medicina de una universidad privada de Lima, Perú / Overlap of irritable bowel syndrome and functional dyspepsia based on Rome III criteria in medical students from a private university in Lima, Peru

Determinar la prevalencia de síndrome de intestino irritable y dispepsia funcional en estudiantes de medicina de una universidad privada en Lima, Perú. Asimismo, determinar los factores asociados a estas patologías. Material y métodos: Estudio de corte transversal observacional, descriptivo, retrospectivo. Se encuestó estudiantes de medicina de una universidad privada en Lima usando un cuestionario auto aplicado para trastornos funcionales Roma III y el cuestionario auto aplicado STEPwise para la definición de variables de consumo de alcohol y tabaco. Para el análisis de datos se usó el programa Stata 11.0. Resultados: De los 608 estudiantes, 543 respondieron el cuestionario. Se encontró una prevalencia de Síndrome de Intestino Irritable del 12,4%, de dispepsia del 16,9% y de ambas patologías simultáneamente, una prevalencia de 7,1%. El consumo de alcohol en la población total fue del 89,4% y de 29,0% de tabaco. Se encontró asociación entre ambas alteraciones (OR: 10,47, IC95% 5,08-21,55; p<0,001), dispepsia se asoció con sexo (OR: 0,16, IC95% 0,07-0,36 p<0,001), con consumo de alcohol (OR: 5,22, IC95% 1,13- 23,99 p=0,034) y con síndrome de intestino irritable (OR: 9,88, IC95% 4,78-20,46 p<0,001). Ambos trastornos en conjunto se asociaron con sexo (OR: 0,20, IC95% 0,06-0,60 p=0,004) y consumo diario de tabaco (OR: 3,23, IC95% 1,17-8,89 p=0,023). Conclusión: Se determinó una prevalencia de 12,4% de Síndrome de Intestino Irritable y 16,9% de dispepsia. Se reportó una superposición de estas patologías en 7,1%...

To determine the prevalence of irritable bowel syndrome and functional dyspepsia in medical students from a private university in Lima, Peru. Furthermore, to determine the associated factors with these diseases. Material and methods: Observational descriptive and retrospective cross sectional study. Medical students from a private university in Lima were surveyed using a Rome III questionnaire for functional disorders and the STEPwise auto survey for defining the variables of alcohol and tobacco. For data analysis the Stata 11.0 program was used. Results: Of the 608 students, 543 answered the questionnaire. The prevalence of Irritable Bowel Syndrome was 12.4%, 16.9% of dyspepsia, and of both diseases simultaneously, a prevalence of 7.1% was found. Alcohol consumption in the total population was 89.4% and 29.0% of tobacco. Association between both disorders was found (OR 10.47, 95% CI 5.08 to 21.55; p <0.001), dyspepsia was associated with sex (OR: 0.16, 95% CI 0.07 to 0.36 p <0.001), with alcohol consumption (OR: 5.22, 95% CI 23.99 1,13- p = 0.034) and with irritable bowel syndrome (OR: 9.88, 95% CI 4.78 to 20.46 p <0.001). Both conditions together were associated with sex (OR: 0.20, 95% CI from 0.06 to 0.60 p = 0.004) and daily consumption of tobacco (OR: 3.23, 95% CI 1.17 to 8.89 p = 0.023). Conclusion: A prevalence of 12.4% of Irritable Bowel Syndrome and 16.9% of dyspepsia was determined. An overlap of 7.1% of these diseases was reported...

Toxoplasmosis congénita / Congenital toxoplasmosis

Introducción: La toxoplasmosis causada por el Toxoplasma gondii se transmite a los humanos de manera transplacentaria, entre otras. Se estima que infecta a un tercio de la población mundial y está asociado con infección congénita y abortos. Solo son sintomáticos del 10 al 20% de los casos. Caso clínico: Se presenta el caso de un recién nacido pretérmino referido a un hospital de mayor complejidad. Durante la hospitalización se realiza el diagnóstico de toxoplasmosis congénita con diversas manifestaciones sistémicas. Conclusiones: La mayor parte de los casos de toxoplasmosis congénita suelen ser asintomáticos. Es necesario realizar pruebas diagnósticas y un examen físico completo ante la sospecha de la infección para detectar tempranamente todas las manifestaciones posibles.

Background: Toxoplasmosis, caused by Toxoplasma gondii, is transmitted to humans in several ways, such as transplacental spread. It is estimated that this parasite infects a third of the world population and it is associated with congenital infection and fetal loss. Only 10 to 20% of the cases are symptomatic. Case report: We present the case of a pre-term newborn that had been referred to a tertiary care center. During the in-hospital period, diagnosis of congenital toxoplasmosis with many systemic manifestations was performed. Conclusions: Most cases of congenital toxoplasmosis are asymptomatic. Diagnosis tests and a complete physical examination should be performed on all newborns with suspicion of infection to detect all possible manifestations as in the case reported.

[Congenital toxoplasmosis]. / Toxoplasmosis congénita.

BACKGROUND: Toxoplasmosis, caused by Toxoplasma gondii, is transmitted to humans in several ways, such as transplacental spread. It is estimated that this parasite infects a third of the world population and it is associated with congenital infection and fetal loss. Only 10 to 20% of the cases are symptomatic. CASE REPORT: We present the case of a pre-term newborn that had been referred to a tertiary care center. During the in-hospital period, diagnosis of congenital toxoplasmosis with many systemic manifestations was performed. CONCLUSIONS: Most cases of congenital toxoplasmosis are asymptomatic. Diagnosis tests and a complete physical examination should be performed on all newborns with suspicion of infection to detect all possible manifestations as in the case reported.