Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 23
Filtrar
1.
Front Oncol ; 14: 1359093, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38774414

RESUMEN

Dabrafenib plus trametinib is a promising new therapy for patients affected by BRAFV600E-mutant glioma, with high overall response and manageable toxicity. We described a complete and long-lasting response in a case of recurrent anaplastic pleomorphic xanthoastrocytoma CNS WHO-grade 3 BRAFV600E mutated. Due to very poor prognosis, there are a few described cases of high-grade glioma (HGG) patients treated with the combined target therapy as third-line treatment. The emergence of optimized sequencing strategies and targeted agents, including multimodal and systemic therapy with dabrafenib plus trametinib, will continue to broaden personalized therapy in HGG improving patient outcomes.

3.
Front Oncol ; 13: 1244628, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37799478

RESUMEN

Low grade gliomas (LGGs) of pineal region are usually difficult to remove and they frequently relapse or progress after front line chemotherapy. Bevacizumab-Irinotecan (BEVIRI) combination has been successfully attempted in children with recurrent LGGs, in most cases not previously irradiated. The efficacy of bevacizumab has also been described in radiation necrosis. Considering the possible overlapping of radiation treatment effect and disease progression and difficulty in differentiating, we report on the use of BEVIRI in a case of a recurrent relapsing low-grade glioma of the pineal region, subjected to multiple neurosurgical interventions, also treated with a carboplatin-etoposide regimen and a radiation course, at present at one-year follow-up showing a stable response, with no adverse events.

4.
Am J Cancer Res ; 13(8): 3668-3678, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37693163

RESUMEN

Children and young adult with high grade gliomas (HGG) have dismal prognoses and treatment options remain limited. We present 19 patients diagnosed with anaplastic astrocytoma (AA) or glioblastoma (GBM) treated with concomitant and adjuvant 20-30 mg/m2/dose of vinorelbine and 30 mg/kg/day valproic acid (VA) in combination to consolidated TMZ and focal RT after maximal surgery. We evaluated the feasibility of treating children diagnosed with HGG. The median follow-up time was 51.4 months (range, 6.2-106.6 months). The 5-year OS was 57.9% (CI 95%, 33.2-76.3) and the 5-year PFS was 57.9% (CI 95%, 33.2-76.3). Eight patients (42.1%) have progressed so far, with a median time to progression of 9 months from diagnosis (range, 4.6-34.7 months). All of them died for disease progression. At time of analysis, 11 patients were still alive with no evidence of disease. It is notable that all events occurred within 35 months from the start of therapy. All 19 treated patients reported low-grade drug-related adverse events (AEs). The treatment was well tolerated in our limited cohort of patients without significant toxicity. Further studies of the efficacy and safety of combination of vinorelbine/VA to consolidated RT/TMZ therapy in children with HGG are underway in a clinical trial setting.

5.
Childs Nerv Syst ; 39(9): 2493-2497, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-37526681

RESUMEN

PURPOSE: During the last decade, there has been renewed interest in stereotactic approaches to diffuse intrinsic pontine gliomas (DIPGs) in children, due to the development of new concepts in molecular biology and management, and subsequent need for tissue sampling. Stereotactic frame-based and robot-assisted techniques are associated with reduced target error and have been incorporated into standard practice at our institution. METHODS: Four children (age 2-7 years) underwent a robot-assisted frame-based transcerebellar approach using the Leksell G frame coupled with Renishaw's neuromate® stereotactic robot. The procedures included 3 biopsies (two brainstem tumors and one cerebellar hemispheric lesion) and 1 depth electrode implantation into a low-grade tumor remnant (ganglioglioma) of the middle cerebellar peduncle causing drug-resistant epilepsy in a young girl. Targeting was based on MRI, and in one case, 18F-FET-PET was coregistered to MRI to improve sampling accuracy. The frame was applied 180° rotated compared to standard orientation, and patients were positioned prone during surgery and stereotactic preoperative CT scan. Postoperative CT scan ruled out complications and was coregistered to preoperative MRI to check the target accuracy. RESULTS: No complications occurred, and targeting was accurate in all cases. All tissue samplings provided proper histology; depth electrode EEG exploration was diagnostic and led subsequent resective surgery. CONCLUSIONS: According to our experience, the transcerebellar frame-based robotic stereotactic approach to the cerebellum and the brainstem is feasible, safe, and effective even in young children.


Asunto(s)
Neoplasias del Tronco Encefálico , Robótica , Femenino , Humanos , Niño , Preescolar , Técnicas Estereotáxicas , Biopsia/métodos , Neoplasias del Tronco Encefálico/patología
6.
Eur J Med Genet ; 66(7): 104784, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37164167

RESUMEN

We report the case of a 16-year-old girl presenting with spinal clear-cell multiple meningiomas (CCMs). In view of this presentation, we sequenced a bioinformatic panel of genes associated with susceptibility to meningioma, identifying a germline heterozygous variant in SMARCE1. Somatic DNA investigations in the CCM demonstrated the deletion of the wild-type allele (loss of heterozygosity, LOH), supporting the causative role of this variant. Family segregation study detected the SMARCE1 variant in the asymptomatic father and in the asymptomatic sister who, nevertheless, presents 2 spinal lesions. Germline heterozygous loss-of-function (LoF) variants in SMARCE1, encoding a protein of the chromatin-remodeling complex SWI/SNF, have been described in few familial cases of susceptibility to meningioma, in particular the CCM subtype. Our case confirms the role of NGS in investigating predisposing genes for meningiomas (multiple or recurrent), with specific regard to SMARCE1 in case of pediatric CCM. In addition to the age of onset, the presence of familial clustering or the coexistence of multiple synchronous meningiomas also supports the role of a genetic predisposition that deserves a molecular assessment. Additionally, given the incomplete penetrance, it is of great importance to follow a specific screening or follow-up program for symptomatic and asymptomatic carriers of pathogenic variants in SMARCE1.


Asunto(s)
Neoplasias Meníngeas , Meningioma , Adolescente , Femenino , Humanos , Proteínas Cromosómicas no Histona/genética , Proteínas de Unión al ADN/genética , Mutación de Línea Germinal , Pérdida de Heterocigocidad , Neoplasias Meníngeas/genética , Neoplasias Meníngeas/diagnóstico , Neoplasias Meníngeas/patología , Meningioma/genética , Meningioma/diagnóstico , Meningioma/patología , Factores de Transcripción/genética
7.
Children (Basel) ; 9(9)2022 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-36138616

RESUMEN

We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range-IQR) at different follow-up times and in different sub-groups (stable disease-SD, partial response-PR, and progression disease-PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 µm (IQR 31.5); median pRNFL at the end of treatment was 73 µm (IQR 33); median pRNFL at last follow-up was 72 µm (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation.

8.
Front Psychol ; 13: 815665, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35465560

RESUMEN

Flow is a gratifying state of deep involvement and absorption that individuals report when facing a challenging activity and they perceive adequate abilities to cope with it (EFRN, 2014). The flow concept was introduced by Csikszentmihalyi in 1975, and interest in flow research is growing. However, to our best knowledge, no scoping review exists that takes a systematic look at studies on flow which were published between the years 2000 and 2016. Overall, 252 studies have been included in this review. Our review (1) provides a framework to cluster flow research, (2) gives a systematic overview about existing studies and their findings, and (3) provides an overview about implications for future research. The provided framework consists of three levels of flow research. In the first "Individual" level are the categories for personality, motivation, physiology, emotion, cognition, and behavior. The second "Contextual" level contains the categories for contextual and interindividual factors and the third "Cultural" level contains cultural factors that relate to flow. Using our framework, we systematically present the findings for each category. While flow research has made progress in understanding flow, in the future, more experimental and longitudinal studies are needed to gain deeper insights into the causal structure of flow and its antecedents and consequences.

9.
JRSM Open ; 12(1): 2054270420981454, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33489243

RESUMEN

This case describes the strong utility of optical coherence tomography in multidisciplinary management of a complex case of type 2 neurofibromatosis.

10.
Community Ment Health J ; 56(2): 368-375, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-31583620

RESUMEN

The Mental Health Continuum-Short Form (MHC-SF) is a self-report questionnaire that allows the assessment of positive mental health, including three well-being components-emotional, psychological and social-as well as the categorical diagnosis of the presence or absence of mental health. The purpose of this study is to describe the adaptation and validation of the Portuguese version of MHC-SF and to examine whether this is an adequate measure of positive mental health for the Portuguese context. The participants included 1448 respondents between the ages of 18 and 94 (M = 33.15; SD = 16.3), 70.1% of which were females. Results confirm the reliability (α = .93), tripartite factor structure, and the external and internal validity of the MHC-SF. Data also supported the two-continuum model, with positive mental health and mental illness belonging to two correlated but distinct dimensions. These findings indicated that the Portuguese MHC-SF is valid instrument to measure well-being and positive mental health.


Asunto(s)
Salud Mental , Calidad de Vida , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Persona de Mediana Edad , Portugal , Psicometría , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Adulto Joven
11.
Investig. enferm ; 222020. tab
Artículo en Portugués | LILACS, BDENF - Enfermería, COLNAL | ID: biblio-1178687

RESUMEN

Objetivo: Avaliar a eficácia de um programa de promoção da inteligência emocional, em enfermeiros em exercício de funções num hospital do Porto. Metodo: Estudo exploratório e quase-experimental, misto, com recurso à Escala de Inteligência Emocional de Wong e Law; Continuum de Saúde Mental- versão reduzida para adultos; Escala de Ansiedade, Depressão e Stress ­ 21 itens; Rahim Organizational Conflict Inventory. A amostra incluiu 6 enfermeiros, maioritariamente do sexo feminino, com idades compreendidas entre os 29 e os 35. Resultados: Os enfermeiros desenvolveram e aplicaram estratégias mais eficazes ao nível da autoconsciência, clarificação, autorregulação emocional, comunicação e gestão do conflito, permitindo um maior bem-estar social e emocional. Conclusões: O desenvolvimento de competências de Inteligência Emocional são essenciais na prestação de cuidados, permitindo a adoção de comportamentos adaptativos, a aprimoração de habilidades de gestão/regulação emocional promovendo o bem-estar, fulcrais para o processo de humanizar os cuidados.


Objective: To evaluate the effectiveness of a program to promote emotional intelligence on nurses working on their regular functions in a hospital in Porto. Method: Exploratory quasi-experimental mixed study using as resources the Wong and Law Emotional Intelligence Scale; Mental Health Continuum - short version for adults; the Anxiety, Depression, and Stress Scale - 21 items; and the Rahim Organizational Conflict Inventory. The sample included 6 nurses, most of them female, between 29 and 35 years of age. Results: The nurses developed and applied more effective strategies at the self-awareness, clarification, emotional self-regulation, communication, and conflict management levels, allowing for greater social and emotional well-being. Conclusions: The development of Emotional Intelligence competencies is essential in the provision of care, enabling the adoption of adaptive behaviors, the improvement of management/emotional regulation skills for the promotion of well-being, which are central to the humanization process of care.


Objetivo: Evaluar la eficacia de un programa de promoción de la inteligencia emocional, en enfermeros en ejercicio de sus funciones en un hospital do Porto. Método: Estudio exploratorio de corte casi-experimental, mixto, con recursos en la Escala de Inteligencia Emocional de Wong y Law; Continuum de Salud Mental- versión reducida para adultos; Escala de Ansiedad, Depresión y estrés ­ 21 items; Rahim Organizational Conflict Inventory. La muestra incluyó 6 enfermeros, mayoritariamente de sexo femenino, con edades comprendidas entre los 29 y los 35 años. Resultados: Los enfermeros desarrollaron y aplicaron estrategias más eficaces a nivel de la autoconsciencia, la clarificación, la autorregulación emocional, la comunicación y la gestión del conflicto, permitiendo un mayor bienestar social y emocional. Conclusiones: El desarrollo de competencias de Inteligencia Emocional son esenciales en la prestación de cuidados, permitiendo la adopción de comportamientos adaptativos, el perfeccionamiento de habilidades de gestión/regulación emocional promoviendo el bienestar, centrales para el proceso de humanización de los cuidados.


Asunto(s)
Humanos , Efectividad , Inteligencia Emocional , Enfermeras y Enfermeros
12.
J Med Syst ; 42(9): 159, 2018 Jul 18.
Artículo en Inglés | MEDLINE | ID: mdl-30019171

RESUMEN

The purpose of the present study was to explore the relation of work-related risk factors and well-being among healthcare workers and the impact on patient safety, using the Health and Work Survey (INSAT) and Mental Health Continuum - Short Form (MHC-SF). A sample of 361 Portuguese healthcare workers participated in this study. The results indicate some significant work-related risk factors: for emotional well-being, Impossible to express myself (ß = -0.977), Not having recognition by superiors (ß = -1.028) and Have to simulate good mood and/or empathy (ß = -1.007); for social well-being, Exposed to the risk of sexual discrimination (ß = -2.088), Career progress is almost impossible (ß = -1.518), and Have to hide my emotions (ß = -2.307); finally for psychological well-being Exposed to the risk of sexual discrimination (ß = -2.153), Career progress is almost impossible (ß = -1.377), and Have to simulate good mood and/or empathy (ß = -3.201). The results showed high levels of well-being despite the exposure of several risk factors at workplace. Regarding the work-related risk factors, the study showed that most of the participants are exposed to several risk factors at workplace (ranging from environmental risk factors, biological to physical), although psychosocial risk factors (work relations with superiors and colleagues, employment relations, and emotional demands) are the ones that most impact on well-being.


Asunto(s)
Personal de Salud , Salud Laboral , Seguridad del Paciente , Humanos , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Lugar de Trabajo
13.
Investig. enferm ; 19(1)ene.-jun. 2017. tab
Artículo en Portugués | LILACS, BDENF - Enfermería, COLNAL | ID: biblio-996294

RESUMEN

Objetivo: Perceber os significados sobre a doenca, morte e perdáo em mulheres com cancro da mama e ainda quais as concecóes relativamente ao futuro após um diagnóstico de cancro. Metodología: foi utilizada urna abordagem qualitativa, através da realizacáo de entrevistas semiestruturadas a um grupo de oito mulheres com diagnóstico de cancro da mama. As historias pessoais foram depois analisadas utilizando a Grounded Analysis para obter urna compreensáo holística e aprofundada do significado que os individuos atribuem á sua experiencia vivencial. Resultados: Os dados encontrados indicam que um diagnóstico de cancro da mama tem um impacto asso-ciado a sentimentos de medo, incapacidade, dependencia e morte. Para enfrentar o cancro, a mulher procura construir um novo significado sobre conceitos como o perdáo, doenca, sonhos para o futuro, tentando encontrar urna redefinicáo dos papéis que Ihe sao atribuidos e procurando ter um novo olhar sobre o significado da vida. Conclusóes: Os resultados dáo indicadores relevantes aos profissionais de saúde, quer de compreensáo ñas mudancas e reformulacáo de significados que ocorrem no doente oncológico, quer ao nivel pessoal provocados pela doenca e seus tratamentos, quer ao nivel familiar e social, e intervencáo no alivio do confronto com o sofrimento e a morte.


Objetivo: Comprender el significado de la enfermedad, la muerte y el perdón en las mujeres con cáncer de mama y las concepciones sobre el futuro después de un diagnóstico de cáncer. Método: se desarrolló un enfoque cualitativo, mediante la realización de entrevistas semi-estructuradas con un grupo de ocho mujeres con diagnóstico de cáncer de mama. Las historias personales fueron analizadas utilizando Grounded Análisis para una comprensión integral y en profundidad del significado que los individuos atribuyen a su experiencia de vida. Resultados: indican que un diagnóstico de cáncer de mama tiene un impacto asociado con sentimientos de miedo, fracaso, dependencia y muerte. Para enfrentar el cáncer, la mujer busca construir un nuevo significado en conceptos tales como el perdón, la enfermedad, los sueños para el futuro, tratando de encontrar una redefinición de los roles asignados a él y que busca tener una nueva mirada sobre el sentido de la vida. Conclusiones: los resultados proporcionan indicadores importantes para los profesionales de salud, para entender los cambios y la alteración de significados que se producen en pacientes con cáncer, ya sea a nivel personal causada por la enfermedad y sus tratamientos, o a nivel familiar y social, e intervenir en la confrontación con el alivio del sufrimiento y la muerte.


Objective: To understand the meaning of illness, death and forgiveness in women with breast cáncer and conceptions about the future after a cáncer diagnosis. Method: A qualitative approach was developed using semi- structured interviews with a group of eight women diagnosed with breast cáncer. Personal histories were analyzed using Grounded Analysis for a comprehensive and in-depth understanding of the meaning that individuáis attribute to their life experience. Results: They indicate that a diagnosis of breast cáncer has an impact associated with feelings of fear, failure, depen-dency and death. To cope with cáncer, the woman seeks to build a new meaning in concepts such as forgiveness, illness, dreams for the future, trying to find a redefini-tion of the roles assigned to cáncer and looking to have a new look on the meaning of life. Conclusions: The results provide important indicators for health professionals to understand the changes and altered meanings that occur in cáncer patients, either on a personal level caused by the disease and its treatment, or family and social level, and intervene in the confrontation with the relief of suffering and death.


Asunto(s)
Neoplasias de la Mama/diagnóstico , Actitud Frente a la Muerte , Neoplasias/psicología , Perdón
14.
CNS Oncol ; 5(3): 131-6, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27226409

RESUMEN

Malignant meningioma has a bad prognosis. Surgery and radiotherapy are the most effective therapeutic options, without an established role for chemotherapy. We report a case of 2-year-old male child with diagnosis of postoperative relapse of a malignant meningioma. Considering the rapid progression, the young age and the lack of effective therapeutic alternatives, the patient underwent multidisciplinary anticancer treatment with a protocol made for soft tissue sarcomas (EpSSG NRSSTS 2005 protocol), with positive outcome. This case represents a successful management of an anaplastic meningioma with a multimodal treatment, including chemotherapy, in a pediatric patient.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Doxorrubicina/uso terapéutico , Ifosfamida/uso terapéutico , Neoplasias Meníngeas/tratamiento farmacológico , Meningioma/tratamiento farmacológico , Neoplasias Encefálicas/tratamiento farmacológico , Preescolar , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Meníngeas/diagnóstico por imagen , Meningioma/diagnóstico por imagen , Sarcoma/tratamiento farmacológico
15.
Cancer Chemother Pharmacol ; 77(4): 857-64, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26988222

RESUMEN

PURPOSE: In infants aged less than 12 months, there are few data on pharmacokinetics of high-dose methotrexate (MTX) for brain tumors at the dose of 8 g/m(2). Consolidated knowledges are present only with the dose of 5 g/m(2) in acute lymphoblastic leukemia. METHODS: We collected data on 8 infants at the time of their first treatment with high-dose MTX, 8 g/m(2), to evaluate the pharmacokinetic profile. All children had a dose adjustment with a weight-based prescription (1 m(2) = 30 kg). RESULTS: The median age was 4.5 months (range 0-9). The median weight was 5.63 kg (range 3.12-9.0). The median steady-state MTX concentration at the end of 6-hr infusion was 486 µM/L (range 227-790). The median systemic MTX clearance was 4.14 L/h/m(2) (range 1.98-9.35). The median MTX concentration after 24 h from the beginning of infusion was 3.29 µM/L (range 1.14-100.44). Three (37.5 %) patients had a delayed elimination of MTX (delayed early, delayed late, or total delayed: one for each). These altered elimination occurred principally in children weighing less than 4 kg (p: 0.0179). Moreover, a systemic MTX clearance at the end of infusion minor than 3 L/h/m(2) can predict a delayed elimination (p: 0.0179). Patients with altered elimination underwent rescue measures (leucovorin supplement and/or exchange transfusion). CONCLUSIONS: Our data suggest that a higher dose of MTX for the treatment of aggressive brain tumors in early infants had an acceptable pharmacokinetic profile. Greater attention must be used in the treatment of children weighing less than 4 kg.


Asunto(s)
Antimetabolitos Antineoplásicos/farmacocinética , Neoplasias Encefálicas/tratamiento farmacológico , Metotrexato/farmacocinética , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos
16.
Anticancer Res ; 34(2): 905-7, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24511030

RESUMEN

BACKGROUND: Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT: We report a case of extra-gastrointestinal stromal tumor in a 76-year-old male, Eastern Cooperative Oncology Group (ECOG) performance status of 2. Abdominal Computed Tomography (CT) showed multiple non-homogeneous confluent nodules at the level of the greater omentum and mesentery, involving the bladder and rectum, with additional peritoneal nodules in the upper abdomen. In March 2008, the patient started imatinib mesylate at 400 mg/day. Instrumental examinations showed progressive response until thoracic-abdominal CT in February 2012 which documented a complete response. Follow-up ended in October 2013. Treatment with imatinib, in addition to pathological response, provided clinical benefit, a progressive regression of symptoms and improved the patient's ECOG performance status from 2 to 0.


Asunto(s)
Antineoplásicos/uso terapéutico , Benzamidas/uso terapéutico , Neoplasias Gastrointestinales/tratamiento farmacológico , Neoplasias Gastrointestinales/patología , Tumores del Estroma Gastrointestinal/tratamiento farmacológico , Piperazinas/uso terapéutico , Pirimidinas/uso terapéutico , Anciano , Tumores del Estroma Gastrointestinal/patología , Humanos , Mesilato de Imatinib , Masculino , Mesenterio/patología , Epiplón/patología , Neoplasias Peritoneales/tratamiento farmacológico , Neoplasias Peritoneales/patología , Neoplasias del Recto/tratamiento farmacológico , Neoplasias del Recto/patología , Neoplasias de la Vejiga Urinaria/tratamiento farmacológico , Neoplasias de la Vejiga Urinaria/patología
17.
Blood Transfus ; 8(2): 107-12, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20383304

RESUMEN

BACKGROUND: The fields of application of topically administered platelet derivatives are numerous and increasing. The use of this blood component is based on the fact that it contains growth factors and proteins of the clotting system. Studies carried out so far have been aimed at identifying these substances, assaying their content in the various types of platelet concentrate used, determining the in vivo and in vitro mechanisms of action, and trying to standardise the production methods. However, much still remains to be discovered, not only about the growth factors, but also about all those cytokines and biochemical mediators that are involved in the processes of tissue regeneration. METHODS: We studied the use of platelet lysate, obtained from platelet-rich plasma which had been frozen, for the treatment of corneal ulcers caused by neurotrophic keratitis and of epithelial and stromal loss following physical or chemical trauma. The platelet lysate was administered in the form of eye drops to patients who had not responded to conventional therapy and who were at risk of corneal scarring. RESULTS: The results were satisfactory in terms of both tissue regeneration and healing time. The clinical follow-up showed a clear reduction in the time of regeneration of the damaged epithelium and stabilisation of the repair process. The epithelial defects disappeared completely in all the treated eyes within 6 to 32 days, with the time depending on the type of lesion and the severity of the damage. CONCLUSIONS: The cornea reacts to damage by releasing numerous substances, including cytokines, growth factors, proteases and neuropeptides in order to restore its anatomical integrity. A change in the balance between inhibitory and stimulating substances can lead to the development of complications. Fast, correct re-epithelialisation is fundamental for the formation of new, transparent tissue. The use of non-gelified platelet-rich plasma was found to be effective in all cases with loss of epithelium, such as post-herpetic corneal ulcers or ulcers occurring following trauma or exposure to caustic substances.


Asunto(s)
Plaquetas , Extractos Celulares/uso terapéutico , Úlcera de la Córnea/terapia , Regeneración/efectos de los fármacos , Administración Tópica , Adulto , Anciano , Extractos Celulares/administración & dosificación , Extractos Celulares/farmacología , Córnea/fisiología , Úlcera de la Córnea/fisiopatología , Epitelio Corneal/efectos de los fármacos , Epitelio Corneal/patología , Femenino , Estudios de Seguimiento , Humanos , Instilación de Medicamentos , Masculino , Microscopía Confocal , Persona de Mediana Edad , Soluciones Oftálmicas , Estudios Retrospectivos
18.
Psicol. USP ; 20(4): 517-537, out.-dez. 2009.
Artículo en Portugués | Index Psicología - Revistas | ID: psi-46482

RESUMEN

No presente artigo descreve-se um estudo cujo objetivo se centra na identificação e compreensão dos significados e sentidos, narrativamente construídos e organizados por crianças com e sem familiares alcoólicos, relativamente à sua família. Esta investigação enquadra-se na necessidade atual de aprofundar o estudo do consumo de álcool e do seu impacto a nível familiar, principalmente no desenvolvimento das crianças. Foi utilizada uma metodologia qualitativa, recorrendo-se à realização de entrevistas analisadas de acordo com a Grounded Analysis. As entrevistas decorreram com 11 crianças com idades compreendidas entre os 4 e os 10 anos de idade, inseridas nas atividades lúdico-pedagógicas de um projeto social. Seis destas crianças possuem familiares que sofrem de alcoolismo e cinco não. Os resultados apontam para a existência de diferenças entre os discursos dos dois grupos de crianças que constituíram a amostra, sendo que as crianças com familiares alcoólicos manifestaram uma concepção diferente da família, que envolve relações conflituosas e problemas de vários tipos(AU)


With this article we aim to analyse narrative meanings about family, by children with and without alcoholic family members. This investigation underlines the lack of studies about alcohol consumption and its impact to familial environment, mostly on children development. A qualitative design was used, oriented by Grounded Analysis. Data were collected through a semi-structured interview. 11 participants, with ages between 4 and 10 years old that take part of a portuguese social project, were interviewed, six of them have an alcoholic family member and five don't. The results demonstrate the existence of differences between the discourses of the two groups of children that constitute the sample. In fact, family concept of children with alcoholic family members is negative, and reflects various problems and conflicts(AU)


Dans cet article nous décrivons une étude qui a comme sujet l'identification et la compréhension des sens et des significations sur la famille, par des enfants qui avaient et qui n'avaient pas des gens alcooliques dans la famille. Cette investigation a une raison d'être, le besoin actuel d'approfondir l'étude sur la consommation d'alcool, son impact au niveau familial et son influence sur le développement des enfants. On a utilisé une méthode qualitative en se servant de la réalisation de certaines entrevues qui ont été analysées selon la Grounded Analysis. Les entrevues ont été faites à 11 enfants à l'âge entre 4 et 10 ans, qui faisaient partie des activités d'un projet social, 6 d'entre eux avaient des gens alcooliques dans leur famille, les autres 5 n'en avaient pas. Les deux groupes d'enfants démontrèrent une différence au niveau du discours, ceux qui en avaient dans leurs familles des gens alcooliques montrèrent, d'une certaine manière, une conception plus négative de la famille, qui montre plusieurs problèmes et des conflits familiers(AU)


En el presente artículo, describe se un estudio cuyo objetivo se centra en la identificación y comprensión de los significados y sentidos, narrativamente construidos y organizados, por niños con y sin familiares alcohólicos, relativamente à su familia. Esta investigación encuadrase en la necesidad actual de profundar el estudio del consumo del alcohol y de su impacto a nivel familiar, principalmente a nivel del desarrollo de los niños. Fue utilizada una metodología cualitativa, recorriéndose à la realización de entrevistas analizadas de acuerdo con el Grounded Analysis. Las entrevistas descorrieran con 11 niños con edades comprendidas entre los 4 y los 10 años de edad, insertadas en las actividades lúdico-pedagógicas de un proyecto social. Seis de estos niños posean familiares que sufren de alcoholismo y cinco no. Los resultados apuntan para la existencia de diferencias entre los discursos de los grupos de niños que constituyeron la muestra, siendo que los niños con familiares alcohólicos manifestaron una concepción diferente de la familia, que envuelve relaciones conflictivas y problemas de varios tipos(AU)


Asunto(s)
Humanos , Niño , Alcoholismo/psicología , Relaciones Familiares , Desarrollo Infantil
19.
Psicol. USP ; 20(4): 517-537, out.-dez. 2009.
Artículo en Portugués | LILACS | ID: lil-558908

RESUMEN

No presente artigo descreve-se um estudo cujo objetivo se centra na identificação e compreensão dos significados e sentidos, narrativamente construídos e organizados por crianças com e sem familiares alcoólicos, relativamente à sua família. Esta investigação enquadra-se na necessidade atual de aprofundar o estudo do consumo de álcool e do seu impacto a nível familiar, principalmente no desenvolvimento das crianças. Foi utilizada uma metodologia qualitativa, recorrendo-se à realização de entrevistas analisadas de acordo com a Grounded Analysis. As entrevistas decorreram com 11 crianças com idades compreendidas entre os 4 e os 10 anos de idade, inseridas nas atividades lúdico-pedagógicas de um projeto social. Seis destas crianças possuem familiares que sofrem de alcoolismo e cinco não. Os resultados apontam para a existência de diferenças entre os discursos dos dois grupos de crianças que constituíram a amostra, sendo que as crianças com familiares alcoólicos manifestaram uma concepção diferente da família, que envolve relações conflituosas e problemas de vários tipos


With this article we aim to analyse narrative meanings about family, by children with and without alcoholic family members. This investigation underlines the lack of studies about alcohol consumption and its impact to familial environment, mostly on children development. A qualitative design was used, oriented by Grounded Analysis. Data were collected through a semi-structured interview. 11 participants, with ages between 4 and 10 years old that take part of a portuguese social project, were interviewed, six of them have an alcoholic family member and five don't. The results demonstrate the existence of differences between the discourses of the two groups of children that constitute the sample. In fact, family concept of children with alcoholic family members is negative, and reflects various problems and conflicts


Dans cet article nous décrivons une étude qui a comme sujet l'identification et la compréhension des sens et des significations sur la famille, par des enfants qui avaient et qui n'avaient pas des gens alcooliques dans la famille. Cette investigation a une raison d'être, le besoin actuel d'approfondir l'étude sur la consommation d'alcool, son impact au niveau familial et son influence sur le développement des enfants. On a utilisé une méthode qualitative en se servant de la réalisation de certaines entrevues qui ont été analysées selon la Grounded Analysis. Les entrevues ont été faites à 11 enfants à l'âge entre 4 et 10 ans, qui faisaient partie des activités d'un projet social, 6 d'entre eux avaient des gens alcooliques dans leur famille, les autres 5 n'en avaient pas. Les deux groupes d'enfants démontrèrent une différence au niveau du discours, ceux qui en avaient dans leurs familles des gens alcooliques montrèrent, d'une certaine manière, une conception plus négative de la famille, qui montre plusieurs problèmes et des conflits familiers


En el presente artículo, describe se un estudio cuyo objetivo se centra en la identificación y comprensión de los significados y sentidos, narrativamente construidos y organizados, por niños con y sin familiares alcohólicos, relativamente à su familia. Esta investigación encuadrase en la necesidad actual de profundar el estudio del consumo del alcohol y de su impacto a nivel familiar, principalmente a nivel del desarrollo de los niños. Fue utilizada una metodología cualitativa, recorriéndose à la realización de entrevistas analizadas de acuerdo con el Grounded Analysis. Las entrevistas descorrieran con 11 niños con edades comprendidas entre los 4 y los 10 años de edad, insertadas en las actividades lúdico-pedagógicas de un proyecto social. Seis de estos niños posean familiares que sufren de alcoholismo y cinco no. Los resultados apuntan para la existencia de diferencias entre los discursos de los grupos de niños que constituyeron la muestra, siendo que los niños con familiares alcohólicos manifestaron una concepción diferente de la familia, que envuelve relaciones conflictivas y problemas de varios tipos


Asunto(s)
Humanos , Niño , Alcoholismo/psicología , Desarrollo Infantil , Relaciones Familiares
20.
Paidéia (Ribeirão Preto) ; 17(36): 79-87, jan.-abr. 2007. tab
Artículo en Portugués | Index Psicología - Revistas | ID: psi-40778

RESUMEN

Atualmente, o lazer e as atitudes face ao lazer têm sido alvo de interesse na investigação psicológica, concretamente no domínio da Psicologia Social. O objetivo do presente estudo foi adaptar a escala Leisure Attitude Scale de Raghb e Beard, construída para avaliar as atitudes face ao lazer em função das três componentes de atitude (cognitiva, afetiva e comportamental) para a população de estudantes, adolescentes e jovens adultos portugueses. Participaram no estudo 462 sujeitos (57,8 por cento do sexo feminino e 42,2 por cento do sexo masculino), com uma média de idades de 19,97 (desvio padrão de 4,85). Os resultados obtidos confirmam a estrutura e as características psicométricas da versão original, refletindo valores largamente aceitáveis de fidelidade (consistência interna) e validade (validade de conteúdo) quer para a escala total quer para as várias sub-escalas (cognitiva, afetiva e comportamental). Conclui-se pela adequação da escala na medida das atitudes face ao lazer, no contexto português.(AU)


Nowadays, the leisure and its attitudes constitute an important issue in Social Psychology research. The aim of this study was to realize the adaptation of the Leisure Attitude Scale (Ragheb and Beard) for Portuguese individuals, including adolescents and young adults. This scale measures leisure attitude according to the three components (cognitive, affective and behavioural). A sample of 462 students (57.8 percent girls and 42.2 percent boys) with a mean age of 19.97 (standard deviation of 4.85). The results confirm the original scale. Validity measures of internal consistency and content validity in the total scale and in the three subscales (Cognitive, affective and behavioural). The scale is an adequate instrument to measure leisure attitudes in the Portuguese context.(AU)


La diversión y las actitudes frente a ella vienes siendo objeto de interés en la investigación de la Psicología Social. Nuestro objetivo fue adaptar la escala Leisure Actitudes Scale de Raghb y Beard, que evalúa actitudes frente a la diversión en función de tres componentes (cognitivo, afectivo , y comportamental), para la población de estudiantes, adolescentes y jóvenes adultos portugueses. Participaron 462 sujetos (57,8 por ciento del sexo femenino y 42,2 por ciento del sexo masculino), con media de edades de 19,97 (desviación standar de 4,85). Se confirmó la estructura y características psicométricas de la versión original, reflejando valores de fidelidad (consistencia interna) y validad (validad de contenido) en la escala total y en las varias sub-escalas (cognitiva, afectiva y comportamental). Concluimos que fue realizada la adaptación de la escala en el contexto portugués.(AU)


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Actividades Recreativas , Adaptación Psicológica , Pesos y Medidas
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...