RESUMEN
Hypercalciuria may be a contributory factor to the disturbed calcium homoeostasis seen in diabetic pregnant rats and their offspring. In diabetes, essential fatty acid metabolism is impaired. We have therefore investigated whether feeding a diet supplemented with essential fatty acids will ameliorate the hypercalciuria of diabetic pregnancy and improve reproductive performance. Female rats were fed a standard rat diet, a fat-free diet plus evening primrose oil or a fat-free diet plus sunflower oil. They were injected with streptozotocin or vehicle and mated. Urine samples were analysed for calcium before injection and during gestation. Term-pregnant diabetic rats fed evening primrose oil showed a 73% reduction in urinary calcium output compared with similar rats fed standard diet (P < 0.001). The corresponding reduction was 44% in diabetic rats fed sunflower oil (P < 0.001). A depletion of essential fatty acids in diabetes may therefore be associated with hypercalciuria; dietary supplementation, particularly with evening primrose oil, appears to correct the problem. Diabetic pregnant rats fed evening primrose oil showed a significantly greater live fetal mass (85 +/- 2 vs 33 +/- 12 g; P < 0.05) compared with similar rats fed standard diet. Such findings may imply a normalization of placental transport by essential fatty acids. Rats fed evening primrose, but not sunflower oil, also showed a reduced incidence of diabetes after streptozotocin injection compared with rats fed standard diet (63 vs 86%). Rats fed on evening primrose oil that did become diabetic were less hyperglycaemic than those on the standard diet (29 +/- 2 vs 37 +/- 2 mmol/l), suggesting that the oil may have anti-diabetic properties.
Asunto(s)
Calcio/orina , Diabetes Mellitus Experimental/orina , Grasas Insaturadas en la Dieta/administración & dosificación , Ácidos Grasos Esenciales/administración & dosificación , Embarazo en Diabéticas/orina , Animales , Glucemia/metabolismo , Calcio/sangre , Diabetes Mellitus Experimental/sangre , Desarrollo Embrionario y Fetal , Femenino , Helianthus , Hipolipemiantes/administración & dosificación , Ácidos Linoleicos , Oenothera biennis , Aceites de Plantas/administración & dosificación , Embarazo , Embarazo en Diabéticas/sangre , Ratas , Ratas Sprague-Dawley , Sodio/sangre , Sodio/orina , Aceite de Girasol , Ácido gammalinolénicoRESUMEN
An overview of the use of hydrocolloid dressings in the care of children's acute and chronic wounds.
Asunto(s)
Cuidados Posteriores , Quemaduras/enfermería , Quemaduras/terapia , Niño , Humanos , Padres/educaciónAsunto(s)
Cuidados Posteriores , Quemaduras/rehabilitación , Adolescente , Quemaduras/psicología , Niño , Inglaterra , Familia , Humanos , Centros de RehabilitaciónAsunto(s)
Cuidados Posteriores , Quemaduras/enfermería , Adolescente , Quemaduras/terapia , Niño , Preescolar , HumanosRESUMEN
This study has shown that a multidisciplinary group approach to counselling parents of burned children will decrease parental anxiety, and that medical, psychological and social problems will feature primarily in group discussions.