RESUMEN
BACKGROUND: Frailty is highly prevalent in elderly people. While significant progress has been made to understand its pathogenesis process, few validated questionnaire exist to assess the multidimensional concept of frailty and to detect people frail or at risk to become frail. The objectives of this study were to construct and validate a new frailty-screening instrument named Frailty Groupe Iso-Ressource Evaluation (FRAGIRE) that accurately predicts the risk for frailty in older adults. METHODS: A prospective multicenter recruitment of the elderly patients was undertaken in France. The subjects were classified into financially-helped group (FH, with financial assistance) and non-financially helped group (NFH, without any financial assistance), considering FH subjects are more frail than the NFH group and thus representing an acceptable surrogate population for frailty. Psychometric properties of the FRAGIRE grid were assessed including discrimination between the FH and NFH groups. Items reduction was made according to statistical analyses and experts' point of view. The association between items response and tests with "help requested status" was assessed in univariate and multivariate unconditional logistic regression analyses and a prognostic score to become frail was finally proposed for each subject. RESULTS: Between May 2013 and July 2013, 385 subjects were included: 338 (88%) in the FH group and 47 (12%) in the NFH group. The initial FRAGIRE grid included 65 items. After conducting the item selection, the final grid of the FRAGIRE was reduced to 19 items. The final grid showed fair discrimination ability to predict frailty (area under the curve (AUC) = 0.85) and good calibration (Hosmer-Lemeshow P-value = 0.580), reflecting a good agreement between the prediction by the final model and actual observation. The Cronbach's alpha for the developed tool scored as high as 0.69 (95% Confidence Interval: 0.64 to 0.74). The final prognostic score was excellent, with an AUC of 0.756. Moreover, it facilitated significant separation of patients into individuals requesting for help from others (P-value < 0.0001), with sensitivity of 81%, specificity of 61%, positive predictive value of 93%, negative predictive value of 34%, and a global predictive value of 78%. CONCLUSIONS: The FRAGIRE seems to have considerable potential as a reliable and effective tool for identifying frail elderly individuals by a public health social worker without medical training.
Asunto(s)
Anciano Frágil , Evaluación Geriátrica/métodos , Medición de Riesgo/métodos , Anciano , Anciano de 80 o más Años , Femenino , Francia , Humanos , Modelos Logísticos , Masculino , Prevalencia , Pronóstico , Estudios Prospectivos , Psicometría/métodos , Psicometría/normas , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Encuestas y CuestionariosRESUMEN
BACKGROUND: Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure). Patients must be at least 60 years old and living in the region of Burgundy-Franche-Comte (France). By following the different phases of the caregiving relationship from the announcement of the diagnosis, it will be possible to assess the quality of life of caregivers, coping strategies, levels of anxiety and depression, social support and the extent of their burden. We will also evaluate the efficacy and efficiency of the implementation of a pragmatic intervention by a social worker to help informal caregivers, through a randomized interventional trial nested in the cohort. Qualitative approaches aimed at studying the caregiver/patient relationship, and situations leading to breakdown of the caregiver relationship will be also undertaken. DISCUSSION: Through an analytical and longitudinal definition of profiles of informal caregivers, this study will gather detailed information on their life courses and their health trajectory by identifying consequences associated with the concept of their role as carers. In addition, the randomized interventional trial will explore the relevance of the implementation of a supportive intervention by a social worker to help caregivers. These data will help to identify strategies that could be used to improve the existing sources of aid and to propose new approaches to help caregivers. This study will provide the opportunity to identify the most relevant means of support adapted to caregivers, and provide an impulse for new health care policies. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02626377 . Retrospectively registered on 9 December 2015. Protocol date/version: 23 October 2014/version 2.
Asunto(s)
Envejecimiento , Enfermedades Cardiovasculares/terapia , Cuidadores/psicología , Neoplasias/terapia , Enfermedades Neurodegenerativas/terapia , Apoyo Social , Trabajadores Sociales , Adaptación Psicológica , Factores de Edad , Anciano , Ansiedad/diagnóstico , Ansiedad/etiología , Ansiedad/psicología , Enfermedades Cardiovasculares/diagnóstico , Enfermedades Cardiovasculares/psicología , Investigación sobre la Eficacia Comparativa , Costo de Enfermedad , Depresión/diagnóstico , Depresión/etiología , Depresión/psicología , Femenino , Francia , Estado de Salud , Humanos , Vida Independiente , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Neoplasias/diagnóstico , Neoplasias/psicología , Enfermedades Neurodegenerativas/diagnóstico , Enfermedades Neurodegenerativas/psicología , Estudios Prospectivos , Investigación Cualitativa , Calidad de Vida , Proyectos de Investigación , Factores de TiempoRESUMEN
The treatment of neutrophilic panniculitis can be challenging. We report a patient with a difficult-to-treat neutrophilic panniculitis who had a spectacular response to a short treatment course with the IL-1 antagonist anakinra. A 61-year-woman had a 12-year history of a serious febrile neutrophilic panniculitis and a personal history of steroid-induced pancreatitis and life-threatening methemoglobinemia under antimalarials and dapsone. When she developed a new flare, she was treated successfully with a 15-day course of subcutaneously administered injections of 100 mg anakinra. This observation is the first report attesting the efficiency of anakinra in neutrophilic panniculitis. It expands the potential indications of IL-1 inhibition in the field of the neutrophilic dermatoses, or more generally, in neutrophil-mediated systemic diseases. It underscores the potential pathogenic involvement of IL-1 in those diseases, a hallmark of autoinflammation, and supports their nosologic classification among diseases involving primarily the innate immune system.
Asunto(s)
Proteína Antagonista del Receptor de Interleucina 1/uso terapéutico , Neutrófilos , Paniculitis/tratamiento farmacológico , Receptores de Interleucina-1/antagonistas & inhibidores , Dapsona/efectos adversos , Dapsona/uso terapéutico , Femenino , Fiebre/tratamiento farmacológico , Humanos , Proteína Antagonista del Receptor de Interleucina 1/administración & dosificación , Proteína Antagonista del Receptor de Interleucina 1/efectos adversos , Persona de Mediana Edad , Paniculitis/inmunología , Paniculitis/patología , Resultado del TratamientoRESUMEN
For the last three years, our oncology ICU (intensive care unit) has been opened to visiting children between 0 and 18 years. Our objective was to attempt to decrease the psychological burden in critically ill cancer patients and their children. We report here the evaluation of this new policy. Encouraged by the child psychologists in our hospital, we first recorded the opinions of the nursing staff, patients and relatives about this innovative approach. As our preliminary findings were favourable, a liberalised greeting and education policy for visiting children was implemented. A dedicated procedure was followed in order to provide children with a better understanding of their parent's disease, to alleviate any traumatic experience the visit might cause and to create an environment where mutual confidence would reign. After 2 years, each visiting child, patient, accompanying parent and the nursing staff were directly questioned using a specifically designed questionnaire. The daily lives of the staff, children, families and patients themselves appeared to be dramatically improved, even in the most difficult medical situations. Based on these promising results, the new policy has definitively been adopted in our unit. We propose that children ought to be allowed to visit a parent in the ICU and that this policy warrants evaluation in other types of units.