RESUMEN
We report a case of leucoencephalopathy with tremor and generalized motor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient. There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1 260 ng/ml; therapeutic range: 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present. All neurological symptoms were reversible after Cy A level was lowered. Three months later, a blood Cy A level at 217 ng/ml due to nicardipine co-administration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.
Asunto(s)
Ciclosporina/efectos adversos , Leucoencefalopatía Multifocal Progresiva/inducido químicamente , Ciclosporina/administración & dosificación , Ciclosporina/sangre , Sobredosis de Droga , Electroencefalografía , Femenino , Humanos , Trasplante de Riñón , Leucoencefalopatía Multifocal Progresiva/diagnóstico por imagen , Persona de Mediana Edad , Remisión Espontánea , Tomografía Computarizada por Rayos XRESUMEN
We present a case of lesion of the deep branch of ulnar nerve at the wrist caused by fracture of the hook of the hamate. According to Wu's classification (1985) based on clinical and electromyographic findings and the clinicoanatomic correlations, our case corresponds to type IV of this classification with a pure motor ulnar neuropathy with sparing of hypothenar muscles. Improvement was observed after surgery.