Asunto(s)
Infertilidad , Humanos , Femenino , Infertilidad/terapia , Infertilidad/diagnóstico , Masculino , Técnicas Reproductivas AsistidasAsunto(s)
Preservación de la Fertilidad , Neoplasias , Masculino , Humanos , Testículo , Hombres , Células Germinativas , Criopreservación , EspermatogoniasAsunto(s)
Dieta , Ejercicio Físico , Receptor del Péptido 1 Similar al Glucagón , Obesidad , Salud Reproductiva , Humanos , Masculino , Receptor del Péptido 1 Similar al Glucagón/agonistas , Obesidad/complicaciones , Análisis de Semen , Recuento de Espermatozoides , Motilidad Espermática , EspermatozoidesRESUMEN
RESEARCH QUESTION: Do morphokinetic parameters vary between male and female preimplantation embryos? DESIGN: This was a retrospective cohort study of 175 cycles between March 2018 and June 2021 at two reproductive centres. It included time-lapse data from 92 female and 83 male preimplantation embryos exclusively issued from fresh oocyte donation and undergoing intracytoplasmic sperm injection (ICSI). Only fresh elective single-embryo transfers on day 5 were assessed, and the sex of the embryo was confirmed at birth. The morphokinetic parameters analysed were measured in hours post-insemination (hpi). A two-tailed Student's t-test was used to compare the morphokinetics between embryo sexes and a value of P < 0.05 was considered statistically significant. RESULTS: Following strict inclusion criteria to avoid poor-quality preimplantation embryos, no significant differences were found in morphokinetic parameters when comparing cycles that resulted in female versus male live births for the following: time to pronuclear fading (22.1 ± 2.4 versus 22.4 ± 2.9 hpi; Pâ¯=â¯0.52); time to the 2-cell stage (24.6 ± 2.5 versus 25.0 ± 2.5 hpi; Pâ¯=â¯0.34); time to the 3-cell stage (35.3 ± 3.3 versus 35.8 ± 3.1 hpi; Pâ¯=â¯0.28); time to the 4-cell stage (36.3 ± 3.4 versus 36.9 ± 3.7 hpi; Pâ¯=â¯0.20); time to the 5-cell stage (47.9 ± 4.6 versus 48.0 ± 4.8 hpi; Pâ¯=â¯0.88); time to the 8-cell stage (54.0 ± 6.5 versus 54.1 ± 6.5 hpi; Pâ¯=â¯0.91); time to the start of blastulation (86.3 ± 14.6 versus 85.7 ± 15.5 hpi; Pâ¯=â¯0.78); and time to the full blastocyst stage (93.0 ± 16.9 versus 93.2 ± 17.2 hpi; Pâ¯=â¯0.94). CONCLUSIONS: There are no significant differences in morphokinetics between male and female preimplantation embryos.