Severe acute respiratory syndrome coronavirus 2 infection in patients with hematological malignancies in the Omicron era: Respiratory failure, need for mechanical ventilation and mortality in seronegative and seropositive patients.

Background: Patients with hematological malignancies (HM) have a high risk of severe coronavirus disease 2019 (COVID-19), also in the Omicron period. Material and methods: Retrospective single-center study including HM patients with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) infection from January 2022 to March 2023. Study outcomes were respiratory failure (RF), mechanical ventilation (MV), and COVID-related mortality, comparing patients according to SARS-CoV2 serology. Results: Note that, 112 patients were included: 39% had negative SARS-CoV2 serology. Seronegative were older (71.5 vs. 65.0 years, p = 0.04), had more often a lymphoid neoplasm (88.6% vs. 69.1%, p = 0.02), underwent anti-CD20 therapy (50.0% vs. 30.9% p = 0.04) and had more frequently a severe disease (23.0% vs. 3.0%, p = 0.02) than seropositive.Kaplan-Meier showed a higher risk for seronegative patients for RF (p = 0.014), MV (p = 0.044), and COVID-related mortality (p = 0.021). Negative SARS-CoV2 serostatus resulted in a risk factor for RF (hazards ratio [HR] 2.19, 95% confidence interval [CI] 1.03-4.67, p = 0.04), MV (HR 3.37, 95% CI 1.06-10.68, p = 0.04), and COVID-related mortality (HR 4.26, 95% CI 1.09-16.71, p = 0.04). Conclusions: : HM patients with negative SARS-CoV2 serology, despite vaccinations and previous infections, have worse clinical outcomes compared to seropositive patients in the Omicron era. The use of serology for SARS-CoV2 diagnosis could be an easy tool to identify patients prone to developing complications.

A rare case of necrotizing fasciitis of the leg in an intravenous drug user caused by Prevotella denticola.

Background: Intravenous drug users (IDUs) have a high risk of developing skin and soft tissue infections such as erysipelas, abscesses, and less frequently necrotizing fasciitis (NF) or gas gangrene. Rarely, the cause of the infection is microorganisms residing in the oral cavity and can lead to life-threatening infections. Methods: We describe the case of a 43-year-old man intravenous drug user (IDU) who was admitted for intense leg pain following an injection of cocaine at that site. Results: A clinical and radiological diagnosis of NF was made, so the patient was started on empirical antibiotic therapy and underwent surgical fasciotomy (after 8 hours from admission). Prevotella denticola was isolated from multiple intraoperative specimens and was resistant to initial antimicrobial therapy. The man, suffering from periodontal disease, reported sucking the syringe several times to unblock it. Both fasciotomy surgery and adjustment of antimicrobial therapy enabled therapeutic success. Conclusions: In IDUs the risk of deep skin and soft tissue infections is high and may be aggravated by contamination with oral microorganisms. The choice of empirical antibiotic treatment should include agents active against oral cavity anaerobes, such as P. denticola.

Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia.

Introduction: Casirivimab and imdevimab (CAS/IMV) are two non-competing, high-affinity human IgG1 anti-SARS-CoV-2 monoclonal antibodies, that showed a survival benefit in seronegative hospitalized patients with COVID-19. This study aimed to estimate the day-28 risk of mechanical ventilation (MV) and death in individuals hospitalized for severe COVID-19 pneumonia and receiving CAS/IMV. Additionally, it aimed to identify variables measured at the time of hospital admission that could predict these outcomes and derive a prediction algorithm. Methods: This is a retrospective, observational cohort study conducted in 12 hospitals in Italy. Adult patients who were consecutively hospitalized from November 2021 to February 2022 receiving CAS/IMV were included. A multivariable logistic regression model was used to identify predictors of MV or death by day 28 from treatment initiation, and ß-coefficients from the model were used to develop a risk score that was derived by means of leave-one-out internal cross-validation (CV), external CV, and calibration. Secondary outcome was mortality. Results: A total of 480 hospitalized patients in the training set and 157 patients in the test set were included. By day 28, 36 participants (8%) underwent MV and 28 died (6%) for a total of 58 participants (12%) experiencing the composite primary endpoint. In multivariable analysis, four factors [age, PaO2/FiO2 ratio, lactate dehydrogenase (LDH), and platelets] were independently associated with the risk of MV/death and were used to generate the proposed risk score. The accuracy of the score in the area under the curve (AUC) was 0.80 and 0.77 in internal validation and test for the composite endpoint and 0.87 and 0.86 for death, respectively. The model also appeared to be well calibrated with the raw data. Conclusion: The mortality risk reported in our study was lower than that previously reported. Although CAS/IMV is no longer used, our score might help in identifying which patients are not likely to benefit from monoclonal antibodies and may require alternative interventions.

Advances and Challenges in Sepsis Management: Modern Tools and Future Directions.

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare regulatory T cells (Tregs) but significantly affects other lymphocyte subsets, leading to diminished effector functions, altered cytokine profiles, and metabolic changes. The complexity of sepsis stems not only from its pathophysiology but also from the heterogeneity of patient responses, posing significant challenges in developing universally effective therapies. This review emphasizes the importance of phenotyping in sepsis to enhance patient-specific diagnostic and therapeutic strategies. Phenotyping immune cells, which categorizes patients based on clinical and immunological characteristics, is pivotal for tailoring treatment approaches. Flow cytometry emerges as a crucial tool in this endeavor, offering rapid, low cost and detailed analysis of immune cell populations and their functional states. Indeed, this technology facilitates the understanding of immune dysfunctions in sepsis and contributes to the identification of novel biomarkers. Our review underscores the potential of integrating flow cytometry with omics data, machine learning and clinical observations to refine sepsis management, highlighting the shift towards personalized medicine in critical care. This approach could lead to more precise interventions, improving outcomes in this heterogeneously affected patient population.

Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life experience.

AIM: To investigate the efficacy of intravenous (IV) fosfomycin as combination therapy for treatment of difficult-to-treat (DTT) acute and subacute infections with multi-drug-resistant (MDR) Gram-negative bacteria (GNB), and risk factors associated with 90-day mortality. METHODS: A retrospective, observational, monocentric study enrolled patients treated with IV fosfomycin in combination regimens (≥72 h) for proven DTT-MDR-GNB infection. Multi-variate regression analysis identified independent risk factors for 90-day mortality. A propensity score for receiving fosfomycin was performed to control for confounding factors. RESULTS: In total, 70 patients were included in this study: 54.3% had carbapenem-resistant isolates, 31.4% had ceftazidime/avibactam-resistant isolates and 28.6% had ceftolozane/tazobactam-resistant isolates. The main pathogens were Pseudomonas aeruginosa (57.1%) and Klebsiella pneumoniae (22.9%). The most prevalent infections were nosocomial pneumonia (42.9%), osteomyelitis (17.1%) and intra-abdominal infections. All-cause 30- and 90-day mortality were 15.7% and 31.4%, respectively (18.9% and 50% considering acute DTT-MDR-GNB infections alone). Relapse at 30 days occurred in 22.9% of cases (29% with emergence of fosfomycin resistance). Mortality at 90 days was independently associated with septic shock and ceftolozane/tazobactam resistance. The relationship between resistance to ceftolozane/tazobactam and 90-day mortality was confirmed to be significant after adjustment by propensity score analysis (hazard ratio 5.84, 95% confidence interval 1.65-20.68; P=0.006). CONCLUSIONS: Fosfomycin seems to be a promising salvage, combination treatment in DTT-MDR-GNB infections. Resistance to ceftolozane/tazobactam seems to be independently associated with treatment failure. Randomized clinical trials focusing on pathogen and infection sites are needed urgently to demonstrate the superiority of fosfomycin in combination with other agents for the resolution of DTT-MDR-GNB infections.

Como vaga-lumes na escuridão: histórias de adolescentes em instituição de acolhimento / Como luciérnagas en la oscuridad: historias de adolescentes en una institución de acogida / As fireflies in the darkness: stories about adolescents in the shelter care

O artigo apresenta e analisa histórias de vida produzidas a partir de uma experiência realizada com meninas adolescentes em uma instituição do Sul do Brasil. A pesquisa buscou compreender como essas jovens em situação de acolhimento institucional atribuem sentidos às suas vivências e quais processos de subjetivação estão implicados nesses sujeitos marcados pela infâmia. O trabalho está articulado à esfera da Proteção Social Especial e faz uso de algumas chaves de leitura de Michel Foucault para pensar as experiências vivenciadas pelas adolescentes, bem como as relações que atravessam grande parte das instituições de acolhimento brasileiras. Faremos esse exercício analítico com o uso da governamentalidade e da subjetivação. Para compor as histórias de vida inspiradas nos encontros desenvolvidos com as duas participantes da pesquisa, utilizamos o método da cartografia, desenvolvido por Gilles Deleuze e Félix Guattari. A partir desta experiência, problematizamos os efeitos do processo de acolhimento institucional e fomos desafiadas pelas outras possibilidades de resistência e de produção de subjetividades na adolescência.(AU)

The article presents and analyses life stories produced from an experience with adolescents in an institution in Southern Brazil. The research sought to understand how these young people living in out-of-home care attribute meanings to their experiences, and which ways of subjectivation are implicated in these blokes marked by infamy. The work is articulated to the sphere of Special Social Protection and makes use of some keys of reading of Michel Foucault to think about the experiences lived by these adolescents, as well as the relations that cross great part of the Brazilian shelter cares. We will do this analytical exercise with the use of governmentality and subjectivation. To compose the life stories inspired by the meetings developed with the two participants of the research, we used the method of cartography, developed by Gilles Deleuze and Félix Guattari. From this experience, we problematize the effects of the shelter care process and are challenged by the other possibilities of resistance and the production of subjectivities in adolescence.(AU)

El artículo presenta y analiza historias de vida producidas a partir de una experiencia realizada con chicas adolescentes en una institución del sur de Brasil. La investigación buscó comprender cómo estas mujeres jóvenes en situaciones de acogimiento institucional atribuyen significados a sus vivencias y qué procesos de subjetivación están involucrados en estos sujetos marcados por la infamia. El trabajo está vinculado al ámbito de la Protección Social Especial y hace uso de algunas claves de lectura de Michel Foucault para reflexionar sobre las vivencias vividas por las chicas adolescentes, así como las relaciones que permean la mayoría de las instituciones de acogida brasileñas. Haremos este ejercicio analítico utilizando la gobernamentalidad y subjetivación. Para componer las historias de vida inspiradas en los encuentros desarrollados con dos participantes de la investigación, utilizamos el método de la cartografía, desarrollado por Gilles Deleuze y Félix Guattari. A partir de esta experiencia, problematizamos los efectos del proceso de acogimiento institucional y fuimos desafiados por otras posibilidades de resistencia y producción de subjetividades en la adolescencia.(AU)

O ato de narrar e a produção de conhecimento em psicologia social / The act of narrating and the production of knowledge in social psychology / El acto de narrar y la producción de conocimiento en psicología social

Este artigo tem como objetivo discutir possibilidades teóricas no que tange às narrativas de mulheres, dando a ver um ensaio composto por plurais vozes. Partimos do campo da Psicologia Social, a fim de pluralizar suas referências diante daquilo que incide do/no tempo presente e que permeia as discussões pertinentes aos estudos de gênero. Para tanto, buscamos dialogar com autores e autoras que não costumam frequentar as páginas de textos desta área, tais como Conceição Evaristo. Nossa aposta metodológica pauta-se na ideia de narrar enquanto meio de produção de histórias de mulheres que, por sua vez, produzem conhecimento; elegemos um viés interseccional, numa discussão que leve em conta marcadores de raça, gênero e classe social. Deste modo, pactuamos com a ideia de que a produção de conhecimento em Psicologia possa se dar pela produção de novas narrativas, nas quais estas mulheres sejam reconhecidas como protagonistas e porta-vozes de suas próprias histórias.

This article aims to discuss theoretical possibilities regarding women's narratives, presenting an essay composed of plural voices, starting from the field of Social Psychology, in order to pluralize their references in face of what affects / at the present time and which permeates the pertinent discussions to gender studies. Therefore, we seek to start a conversation with authors who do not usually partake on texts in this area, such as Conceição Evaristo. Our methodology focus is based on the idea of narration as a mean of reproducing stories of women who, in turn, generates knowledge; we present their narratives through an intersectional bias, whether in a discussion that takes into account markers of race, gender and/or social class. As such, we agree with the idea that generating knowledge in Psychology can happen through bringing to light new narratives, in which these women are recognized as protagonists and spokespeople of their own stories.

Este artículo tiene como objetivo discutir posibilidades teóricas con respecto a las narrativas de mujeres, mostrando un ensayo compuesto de voces plurales. Comenzamos, por lo tanto, desde el campo de la psicología social, para pluralizar sus referencias frente a lo que afecta / en la actualidad y lo que impregna las discusiones pertinentes a los estudios de género. Por lo tanto, buscamos dialogar con autores que generalmente no visitan las páginas de textos en esta área, como Conceição Evaristo. Nuestro enfoque metodológico se basa en la idea de narrar como un medio para producir historias de mujeres que, a su vez, producen conocimiento; presentamos sus narrativas a través de un sesgo interseccional, ya sea en una discusión que tenga en cuenta los marcadores de raza, género y clase social. De esta manera, estamos de acuerdo con la idea de que la producción de conocimiento en Psicología puede ocurrir a través de la producción de nuevas narrativas, en las que estas mujeres son reconocidas como protagonistas y portavoces de sus propias historias.

Um céu estrelado. Como acreditar em um mundo sem nós? Manifesto memória como céu de amor irreversível / A starry sky. How to believe in a world without us? Manifest memory as a sky of irreversible love / Un cielo estrellado. ¿Cómo creer en un mundo sin nosotros? Manifiesto memoria como cielo de amor irreversible

Este texto foi escrito pelos integrantes do grupo de pesquisa Corpo, Arte e Clínica após o falecimento de nossa querida orientadora, professora e amiga Tania Mara Galli Fonseca, cuja presença em nossas vidas deixa marcas da ordem do indizível. O texto foi lido em voz alta junto à comunidade acadêmica no evento Temas em Debate, em 25/10/2019. Na plateia havia pessoas que a admiravam e amavam, tanto por sua pessoa quanto por seu significativo trabalho de escrita e pesquisa, sua incessante produção de pensamento diante dos mais sensíveis pulsares revolucionários da vida coletiva. Para quem endereçaríamos nossas escritas dali para frente? - nos perguntávamos uns aos outros. Com vozes embargadas de saudade e dor, em torno de pequenas luzes que brilhavam como vagalumes na escuridão, dedicamos à Tania esse texto. Escrito a muitas mãos, assim como ela nos ensinou, buscamos palavras para homenageá-la ao colocarmos nossa saudade em movimento.

This text was written by the members of the research group Corpo, Arte e Clínica after the passing of our dear supervisor, teacher and friend Tania Mara Galli Fonseca, whose presence in our lives leaves marks of the unspeakable. The text was read aloud along with the academic community at the Themes in Debate event, on 10/25/2019. In the audience there were people who admired and loved her, due to both for her person and also for her significant work of writing and research, her incessant production of thought in the face of the most sensitive revolutionary pulsars of collective life. To whom would we address our writings from now on? - we asked each other. With voices choked with longing and pain, around small lights that shone like fireflies in the darkness, we dedicate this text to Tania. Written by many hands, just as she taught us, we look for words to honor her by putting our longing in motion.

Este texto fue redactado por los integrantes del grupo de investigación Corpo, Arte e Clínica tras el fallecimiento de nuestra querida supervisora, profesora y amiga Tania Mara Galli Fonseca, cuya presencia en nuestras vidas deja huellas de lo indecible. El texto fue leído en voz alta junto con la comunidad académica en el evento Temas em Debate, el 25/10/2019. En el público había gente que la admiraba y amaba, tanto por su persona como por su importante labor de escritura e investigación, su incesante producción de pensamiento frente a los púlsares revolucionarios más sensibles de la vida colectiva. ¿A quién dirigiremos nuestros escritos de ahora en adelante? - nos preguntamos el uno al otro. Con voces sofocadas por el anhelo y el dolor, alrededor de lucecitas que brillan como luciérnagas en la oscuridad, dedicamos este texto a Tania. Escrito por muchas manos, como ella nos enseñó, buscamos palabras para honrarla, poniendo en movimiento nuestro anhelo.

Incidence, risk factors and mortality outcome in patients with acute kidney injury in COVID-19: a single-center observational study

BackgroundAcute kidney injury (AKI) is a recently recognized complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate the incidence, risk factors and case-fatality rate of AKI in patients with documented COVID-19. MethodsWe reviewed the health medical records of 307 consecutive patients hospitalized for symptoms of COVID-19 at the University Hospital of Modena, Italy. ResultsAKI was diagnosed in 69 out of 307 (22.4%) patients. The stages of AKI were stage 1 in 57.9%, stage 2 in 24.6% and stage 3 in 17.3%. Hemodialysis was performed in 7.2% of the subjects. AKI patients had a mean age of 74.7{+/-}9.9 years and higher serum levels of the main marker of inflammation and organ involvement (lung, liver, hearth and liver) than non-AKI patients. AKI events were more frequent in subjects with severe lung comprise. Two peaks of AKI events coincided with in-hospital admission and death of the patients. Kidney injury was associate with a higher rate of urinary abnormalities including proteinuria (0.448{+/-}0.85 vs 0.18{+/-}0.29; P=<0.0001) and hematuria (P=0.032) compared to non-AKI patients. At the end of follow-up, 65.2% of the patients did not recover their renal function after AKI. Risk factors for kidney injury were age, male sex, CKD and non-renal SOFA. Adjusted Cox regression analysis revealed that AKI was independently associated with in-hospital death (hazard ratio [HR]=3.74; CI 95%, 1.34-10.46) compared to non-AKI patients. Groups of patients with AKI stage 2-3 and failure to recover kidney function were associated with the highest risk of in-hospital mortality. Lastly, long-hospitalization was positively associated with a decrease of serum creatinine, likely due to muscle depletion occurred with prolonged bed rest. ConclusionsAKI was a dire consequence of patients with COVID-19. Identification of patients at high-risk for AKI and prevention of kidney injury by avoiding dehydration and nephrotoxic agents is imperative in this vulnerable cohort of patients.

Perder-se na cidade, encontrair-se com o tempo / Getting lost in the city at a meeting duration: from instant to the archive space / Se pierde em la ciudade, se-encontra-er con el tiempo: de los instantes ao espacio del archivo

Através de um percurso à deriva, provocado pelo encontro com as imagens intensivas da cidade, buscamos delinear neste artigo, questões relativas à experiência do olhar e da sua possibilidade em extrapolar o campo do visível para encontrar elementos presencialmente ocultos, elementos tais, que guardam a capacidade de se tornarem visuais quando coadunam as linhas do passado com as do presente. Neste caso, tratamos da experiência, como arquivistas, no Acervo da Oficina de Criatividade do Hospital Psiquiátrico São Pedro de Porto Alegre (RS), no qual estabelecemos conexões entre o espaço e os conceitos referentes ao olhar em sua relação com o tempo enquanto memória e esquecimento, surgindo como uma possibilidade de habitar e compor-se com os arquivos de imagens que ali são produzidos.(AU)

Drifting through a flow of intensive images of the city, this research aims to investigate issues related to the experience of the look, considering its potential to extrapolate the realm of visibility and find elements that are actively concealed. Elements that become visible when incorporate lines of past and present. In this study, the work as archivists in the collection of Creativity Workshop of São Pedro Psychiatric Hospital in Porto Alegre (RS) allowed the establishment of connections between space and other concepts regarding perspective, memory and oblivion. The research observated how one can set itself and reside in the image files that are produced in the workshop.(AU)

Através de un recorrido a la deriva, provocado por el encuentro con las imágenes intensivas de la ciudad, buscamos delinear en este artículo, cuestiones relativas a la experiencia de la mirada y de su posibilidad en extrapolar el campo de lo visible para encontrar elementos presencialmente ocultos, elementos tales, que guardan la luz La capacidad de volverse visual cuando coinciden las líneas del pasado con las del presente. En este caso, tratamos de la experiencia, como archivistas, en el Acervo del Taller de Creatividad del Hospital Psiquiátrico São Pedro de Porto Alegre (RS), en el que establecemos conexiones entre el espacio y los conceptos referentes a la mirada en su relación con el tiempo como memoria y El olvido, surgiendo como una posibilidad de habitar y componerse con los archivos de imágenes que allí se producen.(AU)

Arte e loucura como limiar para outra história / Art et folie comme le seuil pour autre histoire / Arte y locura como el umbral para otra historia / Art and madness as the threshold for another history

Pretendemos problematizar arte e loucura, inicialmente discutindo a experiência do pesquisador em relação às imagens do mundo, com o testemunho e a figura do louco e, consequentemente, com o fora que ela evoca. Em seguida nos colocamos diante do muro, situação-limite na qual a loucura enquanto catástrofe e a arte enquanto via poética vêm compor um limiar, ausência que Blanchot transpõe à linguagem para dar a ver outras constelações possíveis, tanto de palavras quanto de seus inomináveis. Por fim, com Walter Benjamin, pomos a história da loucura a contrapelo, e, mergulhados no Ateliê de Escrita do Hospital Psiquiátrico São Pedro, desvelamos que a arte pode, na relação com a loucura, tornar-se a linguagem essencial na perigosa travessia em direção à experiência, transpondo a vivência desse estado assustador para trazer ao mundo outro sentido, reconhecendo outros modos de existência que podem vir a ser outras poéticas de vida.

Nous désirons problématiser l’art et la folie, initialement en discutant l’expérience du chercheur par rapport aux images du monde, avec le témoignage et l’image du fou, et, par conséquent, l’extérieur qu’elle évoque. Puis, on se pose devant le mur, situation extrême dans laquelle la folie comme catastrophe et l’art comme voie poétique composent un seuil viennent à construire un seuil, absence que Blanchot transpose en langage afin de révéler d’autres constellations possibles tant comme des mots, tant comme ses innombrables. Enfin, avec Walter Benjamin, nous prenons l’histoire de la folie à contre-poil, et plongés dans l’Atelier d’écriture de l’Hôpital psychiatrique de São Pedro, à Porto Alegre au Brésil, nous révélons que l’art, par rapport à la folie, peut devenir le langage essentiel de la traversée dangereuse vers l’expérience, en transposant le vécu de cet état terrifiant, afin de donner un autre sens au monde, tout en reconnaissant d’autres modes d’existence qui pourraient devenir d’autres poétiques de vie.

Nuestra intención es de problematizar el arte y la locura, inicialmente discutiendo la experiencia del investigador en relación con las imágenes del mundo, el testimonio y la figura del loco, y por lo tanto con el afuera que ella evoca. Seguidamente, nos ponemos delante de un muro, una situación extrema en la que la locura como catástrofe y el arte como vía poética componen un umbral, una ausencia que Blanchot transpone en lenguaje para revelar las otras constelaciones posibles tanto como palabras, tanto como innombrables otros. Por último, con Walter Benjamin, ponemos la historia de la locura a contra pelo, y sumergidos en el Taller de escritura del Hospital Psiquiátrico São Pedro de Porto Alegre, Brasil, desvelamos que, en relación con la locura, el arte puede convertirse en el lenguaje esencial de ese peligroso pasaje que nos conduce a la experiencia, que transpone lo vivido en este estado aterrador para dar otro sentido al mundo, reconociendo otros modos de existencia que pueden llegar a ser otras poéticas de vida.

We intend to problematize art and madness. We begin by discussing the experience of the researcher in relation to images of the world, to witnessing and to the image of the insane, and then inevitably to the outside they evoke. Subsequently, we stand before a wall, a limit situation in which madness as catastrophe and art as poetics compose a threshold, an absence which Blanchot transposes to language to bring other possible constellations into view, both as words and as their unnamable others. Finally, with Walter Benjamin, we touch upon the grain of the history of madness - immersed in the Writing Workshop at the São Pedro Psychiatric Hospital, in Porto Alegre, Brazil, we reveal that, in relation to madness, art can become the essential language of the perilous passage towards experience, transposing the experience of this horrific state to bring another sense to the world, recognizing other modes of existence which may come to be other poetics of life.

Arte e loucura como limiar para outra história / Art et folie comme le seuil pour autre histoire / Arte y locura como el umbral para otra historia / Art and madness as the threshold for another history

Pretendemos problematizar arte e loucura, inicialmente discutindo a experiência do pesquisador em relação às imagens do mundo, com o testemunho e a figura do louco e, consequentemente, com o fora que ela evoca. Em seguida nos colocamos diante do muro, situação-limite na qual a loucura enquanto catástrofe e a arte enquanto via poética vêm compor um limiar, ausência que Blanchot transpõe à linguagem para dar a ver outras constelações possíveis, tanto de palavras quanto de seus inomináveis. Por fim, com Walter Benjamin, pomos a história da loucura a contrapelo, e, mergulhados no Ateliê de Escrita do Hospital Psiquiátrico São Pedro, desvelamos que a arte pode, na relação com a loucura, tornar-se a linguagem essencial na perigosa travessia em direção à experiência, transpondo a vivência desse estado assustador para trazer ao mundo outro sentido, reconhecendo outros modos de existência que podem vir a ser outras poéticas de vida.

Nous désirons problématiser l´art et la folie, initialement en discutant l´expérience du chercheur par rapport aux images du monde, avec le témoignage et l´image du fou, et, par conséquent, l´extérieur qu´elle évoque. Puis, on se pose devant le mur, situation extrême dans laquelle la folie comme catastrophe et l´art comme voie poétique composent un seuil viennent à construire un seuil, absence que Blanchot transpose en langage afin de révéler d´autres constellations possibles tant comme des mots, tant comme ses innombrables. Enfin, avec Walter Benjamin, nous prenons l´histoire de la folie à contre-poil, et plongés dans l´Atelier d´écriture de l´Hôpital psychiatrique de São Pedro, à Porto Alegre au Brésil, nous révélons que l´art, par rapport à la folie, peut devenir le langage essentiel de la traversée dangereuse vers l´expérience, en transposant le vécu de cet état terrifiant, afin de donner un autre sens au monde, tout en reconnaissant d´autres modes d´existence qui pourraient devenir d´autres poétiques de vie.

Nuestra intención es de problematizar el arte y la locura, inicialmente discutiendo la experiencia del investigador en relación con las imágenes del mundo, el testimonio y la figura del loco, y por lo tanto con el afuera que ella evoca. Seguidamente, nos ponemos delante de un muro, una situación extrema en la que la locura como catástrofe y el arte como vía poética componen un umbral, una ausencia que Blanchot transpone en lenguaje para revelar las otras constelaciones posibles tanto como palabras, tanto como innombrables otros. Por último, con Walter Benjamin, ponemos la historia de la locura a contra pelo, y sumergidos en el Taller de escritura del Hospital Psiquiátrico São Pedro de Porto Alegre, Brasil, desvelamos que, en relación con la locura, el arte puede convertirse en el lenguaje esencial de ese peligroso pasaje que nos conduce a la experiencia, que transpone lo vivido en este estado aterrador para dar otro sentido al mundo, reconociendo otros modos de existencia que pueden llegar a ser otras poéticas de vida.

We intend to problematize art and madness. We begin by discussing the experience of the researcher in relation to images of the world, to witnessing and to the image of the insane, and then inevitably to the outside they evoke. Subsequently, we stand before a wall, a limit situation in which madness as catastrophe and art as poetics compose a threshold, an absence which Blanchot transposes to language to bring other possible constellations into view, both as words and as their unnamable others. Finally, with Walter Benjamin, we touch upon the grain of the history of madness - immersed in the Writing Workshop at the São Pedro Psychiatric Hospital, in Porto Alegre, Brazil, we reveal that, in relation to madness, art can become the essential language of the perilous passage towards experience, transposing the experience of this horrific state to bring another sense to the world, recognizing other modes of existence which may come to be other poetics of life.