1.
Biochem Soc Trans
; 23(4): 604S, 1995 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-8654789
2.
Xenobiotica
; 15(6): 503-11, 1985 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-3839957
RESUMEN
The metabolic fate of chlormethiazole in healthy male subjects has been investigated following the oral administration of a single dose of chlormethiazole edisylate. Five urinary C-oxidation metabolites were identified and shown to be identical with previously reported metabolites. A novel metabolite, of molecular formula C5H7NO2S, was shown by trimethylsilylation, deuterium exchange, reduction studies and by its i.r., n.m.r. and mass spectrum, to be 4,5-dimethylthiazole-N-oxide-S-oxide. This is the first reported metabolite which involves the oxidation of the two heterocyclic atoms in aromatic rings. The formation and thermal stability of the compound is ascribed to resonance stabilization.