RESUMEN
OBJECTIVE: To establish the current status of surgical therapy for chronic pancreatitis, recent published reports are examined in the context of the historical advances in the field. BACKGROUND: The basis for decompression (drainage), denervation, and resection strategies for the treatment of pain caused by chronic pancreatitis is reviewed. These divergent approaches have finally coalesced as the head of the pancreas has become apparent as the nidus of chronic inflammation. METHODS: The recent developments in surgical methods to treat the complications of chronic pancreatitis and the results of recent prospective randomized trials of operative approaches were reviewed to establish the current best practices. RESULTS: Local resection of the pancreatic head, with or without duct drainage, and duodenum-preserving pancreatic head resection offer outcomes as effective as pancreaticoduodenectomy, with lowered morbidity and mortality. Local resection or excavation of the pancreatic head offers the advantage of lowest cost and morbidity and early prevention of postoperative diabetes. The late incidences of recurrent pain, diabetes, and exocrine insufficiency are equivalent for all 3 surgical approaches. CONCLUSIONS: Local resection of the pancreatic head appears to offer best outcomes and lowest risk for the management of the pain of chronic pancreatitis.
Asunto(s)
Pancreatitis Crónica/cirugía , Descompresión Quirúrgica , Procedimientos Quirúrgicos del Sistema Digestivo/métodos , Drenaje , Humanos , Trasplante de Islotes Pancreáticos , Páncreas/cirugía , Pancreatectomía/métodos , Pancreatitis Crónica/etiología , Complicaciones Posoperatorias , SimpatectomíaRESUMEN
OBJECTIVE: To better define the epidemiology of acute pancreatitis in a racially diverse population. METHODS: Analysis of all patients hospitalized in California with first-time acute pancreatitis for the period between January 1994 and September 2001. Subtypes were classified based on the presence or absence of predisposing conditions. RESULTS: There were 70,231 patients hospitalized for first-time acute pancreatitis; 32.6% had biliary tract disease alone, 20.3% had alcohol abuse alone, and 36.6% were idiopathic. The age-standardized incidence increased by 32% from 33.2 to 43.8 cases per 100,000 adults for the period between 1994 and 2001, with the largest increase in the biliary group (52%). The standardized incidence rate of alcoholic and idiopathic pancreatitis was highest in African Americans, whereas biliary pancreatitis was highest in Hispanics. There was no change over time in the percentage of patients dying in the first 14 or 91 days; and in a risk-adjusted model, patients with alcoholic pancreatitis had the highest risk of dying. CONCLUSIONS: The incidence rate of acute pancreatitis rose for the period between 1994 and 2001. However, there was no reduction in the 14- or 91-day case-fatality rate. Further research is needed to explain both the rise in the incidence rate of pancreatitis and the absence of any improvement in the early case-fatality rate.
Asunto(s)
Enfermedades de las Vías Biliares/epidemiología , Pancreatitis Alcohólica/epidemiología , Pancreatitis/epidemiología , Enfermedad Aguda , Adulto , Negro o Afroamericano/estadística & datos numéricos , Distribución por Edad , Factores de Edad , Anciano , Anciano de 80 o más Años , Enfermedades de las Vías Biliares/etnología , Enfermedades de las Vías Biliares/mortalidad , California/epidemiología , Estudios de Cohortes , Femenino , Hispánicos o Latinos/estadística & datos numéricos , Hospitalización , Humanos , Incidencia , Masculino , Registros Médicos , Persona de Mediana Edad , Pancreatitis/etnología , Pancreatitis/mortalidad , Pancreatitis Alcohólica/etnología , Pancreatitis Alcohólica/mortalidad , Distribución por Sexo , Factores SexualesAsunto(s)
Páncreas/patología , Pancreatoyeyunostomía/métodos , Pancreatitis/cirugía , Anastomosis en-Y de Roux/métodos , Enfermedad Crónica , Femenino , Estudios de Seguimiento , Humanos , Masculino , Páncreas/cirugía , Pancreatoyeyunostomía/efectos adversos , Pancreatitis/diagnóstico , Medición de Riesgo , Sensibilidad y Especificidad , Índice de Severidad de la Enfermedad , Resultado del TratamientoAsunto(s)
Enfermedades Pancreáticas/cirugía , Sociedades Médicas/organización & administración , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Cooperación Internacional , Enfermedades Pancreáticas/diagnóstico , Desarrollo de Programa , Evaluación de Programas y Proyectos de Salud , Sociedades Médicas/historia , Estados UnidosAsunto(s)
Becas , Enfermedades Pancreáticas/cirugía , Sociedades Médicas/organización & administración , Humanos , Internado y Residencia , National Institutes of Health (U.S.) , Enfermedades Pancreáticas/diagnóstico , Desarrollo de Programa , Evaluación de Programas y Proyectos de Salud , Sociedades Médicas/tendencias , Estados UnidosRESUMEN
The etiology of pain in chronic pancreatitis may be ductal hypertension, increased parenchymal pressure, or neural damage. It is difficult to assess the severity of pain in this patient population, a problem made more challenging by the frequency of narcotic dependency. Therapeutic interventions developed to relieve the pain of chronic pancreatitis include denervation of the pancreas, decompression of the main duct of the pancreas, resection of part or all of the diseased pancreas, and reduction of pancreatic secretion. Operative intervention for patients with chronic pain is indicated when severe pain, complications of pain, or potential malignancy are present. The operations that consistently provide long-lasting pain relief all have in common resection of all or a portion of the head of the pancreas. Adverse effects on exocrine and endocrine function, nutrition, and quality of life are related to the amount of pancreas resected. The ideal procedure should be easy to perform, have a low morbidity and mortality rate, provide long-lasting pain relief, and not augment endocrine and exocrine insufficiency. No single operation fulfills this ideal. The local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy (LR-LPJ) proposed by Frey and the duodenum-preserving resection of the head of the pancreas (DPHR) proposed by Beger are discussed. The conceptualization, development, and technique of LR-LPJ are discussed, and comparisons of patient outcomes are made with the outcomes of other procedures for chronic pancreatitis.
Asunto(s)
Duodeno/cirugía , Dolor/prevención & control , Pancreatectomía/métodos , Pancreatoyeyunostomía , Pancreatitis/cirugía , Enfermedad Crónica , Humanos , Dolor/etiología , Dimensión del Dolor , Pancreatitis/complicacionesRESUMEN
BACKGROUND: Pancreatic leak is a major source of morbidity associated with pancreatic surgery. We sought to identify disease and technique-dependent factors associated with morbidity and mortality after distal pancreatectomy. METHODS: Retrospective review of patients who underwent distal pancreatectomy during a 5-year period. Clinical, technical, and pathologic data were correlated with operative morbidity or mortality. RESULTS: Fifty-one patients underwent distal pancreatectomy for primary pancreatic disease, extrapancreatic malignancy, or trauma. Overall perioperative mortality and morbidity rates were 4% and 47%, respectively. Pancreatic leak was the most common complication, occurring in 26% of patients. Overall complications and pancreatic leaks occurred more often after distal pancreatectomy for trauma and in patients with a sutured pancreatic stump closure. CONCLUSIONS: Distal pancreatectomy can be performed with a low rate of mortality, though pancreatic leak is a common cause of morbidity. The urgency of the procedure and the method of pancreatic stump closure may influence postoperative morbidity.