Asunto(s)
Enfermedades Cardiovasculares , Hipertrigliceridemia/sangre , Triglicéridos/sangre , Biomarcadores/sangre , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/etiología , VLDL-Colesterol/sangre , Humanos , Hipertrigliceridemia/complicaciones , Morbilidad/tendencias , Estados Unidos/epidemiologíaAsunto(s)
Fibrilación Atrial/tratamiento farmacológico , Antagonistas Adrenérgicos beta/uso terapéutico , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antiarrítmicos/uso terapéutico , Anticoagulantes/uso terapéutico , Fibrilación Atrial/fisiopatología , Biomarcadores/sangre , Ablación por Catéter , Diabetes Mellitus/fisiopatología , Diástole/fisiología , Dilatación Patológica/fisiopatología , Atrios Cardíacos/fisiopatología , Insuficiencia Cardíaca/fisiopatología , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Cumplimiento de la Medicación , Complicaciones Posoperatorias , Medición de Riesgo , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/prevención & control , Volumen Sistólico/fisiología , Sístole/fisiologíaAsunto(s)
Angioplastia Coronaria con Balón , Enfermedad Coronaria/terapia , Stents Liberadores de Fármacos , Acetanilidas/uso terapéutico , Síndrome Coronario Agudo/fisiopatología , Síndrome Coronario Agudo/terapia , Angina de Pecho/diagnóstico , Angioplastia Coronaria con Balón/economía , Antagonistas de Receptores de Angiotensina/economía , Antagonistas de Receptores de Angiotensina/uso terapéutico , Inhibidores de la Enzima Convertidora de Angiotensina/economía , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antitrombinas/economía , Antitrombinas/uso terapéutico , Proteína C-Reactiva/análisis , LDL-Colesterol/sangre , Ensayos Clínicos como Asunto , Angiografía Coronaria , Puente de Arteria Coronaria , Circulación Coronaria , Enfermedad Coronaria/fisiopatología , Trombosis Coronaria/diagnóstico , Trombosis Coronaria/terapia , Análisis Costo-Beneficio , Diabetes Mellitus/epidemiología , Inhibidores Enzimáticos/uso terapéutico , Corazón/diagnóstico por imagen , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/economía , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Estilo de Vida , Anamnesis , Cumplimiento de la Medicación , Tomografía Computarizada Multidetector , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/terapia , Piperazinas/uso terapéutico , Inhibidores de Agregación Plaquetaria/economía , Inhibidores de Agregación Plaquetaria/uso terapéutico , Complejo GPIIb-IIIa de Glicoproteína Plaquetaria/antagonistas & inhibidores , Cintigrafía , Ranolazina , Factores de Riesgo , Troponina/sangreRESUMEN
CONTEXT: Ustekinumab and briakinumab, monoclonal antibodies to the shared p40 subunit of interleukin (IL)-12 and IL-23, have shown efficacy in treating chronic plaque psoriasis (CPP). Preliminary reports of major adverse cardiovascular events (MACEs) in psoriasis patients receiving anti-IL-12/23 agents have prompted concern. OBJECTIVE: To evaluate a possible association between biologic therapies for CPP and MACEs via meta-analysis. DATA SOURCES: Randomized controlled trials (RCTs) of anti-IL-12/23 (ustekinumab and briakinumab) agents and anti-tumor necrosis factor α (TNF-α) agents (adalimumab, etanercept, and infliximab) used in treating CPP were reviewed using the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and Ovid MEDLINE from database inception to May 2011. The results of registered nonpublished completed studies were procured through abstract publications or poster presentations. STUDY SELECTION: Randomized, placebo-controlled, double-blind, monotherapy studies (with safety outcome data for MACE) of IL-12/23 antibodies and anti-TNF-α agents in adults. Studies of psoriatic arthritis were excluded. DATA EXTRACTION: Two investigators independently searched data while 6 investigators reviewed the abstracted data. RESULTS: A total of 22 RCTs comprising 10 183 patients met the predefined inclusion criteria. The primary outcome measure was MACE, a composite end point of myocardial infarction, cerebrovascular accident, or cardiovascular death during the placebo-controlled phase of treatment in patients receiving at least 1 dose of study agent or placebo. Absolute risk differences were used as an effect measure. There was no evidence of statistical heterogeneity across the studies using the I(2) statistic (I(2) = 0), allowing for combination of trial results using the Mantel-Haenszel fixed-effects method. During the placebo-controlled phases of the anti-IL-12/23 studies, 10 of 3179 patients receiving anti-IL-12/23 therapies experienced MACEs compared with zero events in 1474 patients receiving placebo (Mantel-Haenszel risk difference, 0.012 events/person-year; 95% confidence interval [CI], -0.001 to 0.026; P =.12). In the anti-TNF-α trials, only 1 of 3858 patients receiving anti-TNF-α agents experienced a MACE compared with 1 of 1812 patients receiving placebo (Mantel-Haenszel risk difference, -0.0005 events/person-year; 95% CI, -0.010 to 0.009; P = .94). CONCLUSIONS: Compared with placebo, there was no significant difference in the rate of MACEs observed in patients receiving anti-IL-12/IL-23 antibodies or anti-TNF-α treatments. This study may have been underpowered to identify a significant difference.