RESUMEN
A number of recent studies have indicated the potential of ultrasound contrast agent imaging at high ultrasound frequencies. However, the acoustic properties of microbubbles at frequencies above 10 MHz remain poorly understood at present. In this study we characterize the high frequency attenuation properties of (1) BR14, (2) BR14 that has been mechanically filtered (1 and 2 microm pore sizes) to exclude larger bubbles, and (3) the micron to submicron agent BG2423. A narrowband pulse-echo substitution method is employed with a series of four transducers covering the frequency range from 2 to 50 MHz. For BR14, attenuation decreases rapidly from 2 to 10 MHz and then more gradually from 10 to 50 MHz. For 2 microm filtration, the attenuation peaks between 10 and 15 MHz. For 1 microm filtration, attenuation continues to rise until 50 MHz. The agent BG2423 exhibits a diffuse attenuation peak in the range of 15-25 MHz and remains high until 50 MHz. These results demonstrate a strong influence of bubble size on high frequency attenuation curves, with bubble diameters of 1-2 microm and below having more pronounced acoustic activity at frequencies above 10 MHz.
Asunto(s)
Cápsulas/química , Cápsulas/efectos de la radiación , Fluorocarburos/química , Fluorocarburos/efectos de la radiación , Interpretación de Imagen Asistida por Computador/métodos , Microburbujas , Fosfolípidos/química , Fosfolípidos/efectos de la radiación , Ultrasonografía/métodos , Relación Dosis-Respuesta en la Radiación , Aumento de la Imagen/métodos , Lípidos/química , Lípidos/efectos de la radiación , Ensayo de Materiales , Tamaño de la Partícula , Dosis de Radiación , Ondas de RadioRESUMEN
Recently, the in vivo feasibility of tissue harmonic imaging (THI) with a mechanically-rotated intravascular ultrasound (IVUS) catheter was experimentally demonstrated. To isolate the second harmonic signal content, both pulse inversion (PI) and analog filtering were used. In the present paper, we report the development of a simulation tool to investigate nonlinear IVUS beams and the influence of rotation on the efficiency of PI signal processing. Nonlinear 20 MHz beams were simulated in a homogeneous tissue-mimicking medium, resulting in second harmonic pressure fields at 40 MHz. The acoustic response from tissue was simulated by summing radio-frequency (RF) pulse-echo responses from many point-scatterers. When the transducer was rotated with respect to the point-scatterers, the fundamental frequency suppression using PI degraded rapidly with increasing inter-pulse angles. The results of this study will aid in the optimization of harmonic IVUS imaging systems.
Asunto(s)
Algoritmos , Vasos Coronarios/diagnóstico por imagen , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Modelos Cardiovasculares , Ultrasonografía Intervencional/métodos , Simulación por Computador , Humanos , Fantasmas de Imagen , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Ultrasonografía Intervencional/instrumentaciónRESUMEN
Tissue harmonic imaging (THI) has been shown to improve medical ultrasound (US) image quality in the frequency range from 2 to 10 MHz and might, therefore, also be advantageous in high-frequency US applications, like US biomicroscopy and intravascular US (IVUS). In this study, we compared high-frequency THI (40 MHz) with fundamental imaging (20 and 40 MHz) with a distorting reflective metal stent in the near fields of both a spherically-focused US biomicroscopy transducer (aperture 8 mm, focal distance 13 mm) and an unfocused elliptical IVUS element. Hydrophone measurements of the harmonic beam (40 MHz) of both transducers showed relatively low signal strength in the near field compared with both (20 and 40 MHz) fundamental beams. For the focused transducer, THI suppressed the second stent echo up to 14 dB compared with fundamental imaging. No significant reduction in stent artifact imaging was observed for the unfocused IVUS element.
