Acute primary Chlamydophila pneumoniae bronchitis and bronchial hyperresponsiveness in young nonasthmatic Thai military recruits.

BACKGROUND: A correlation between chronic Chlamydophila pneumoniae infection and chronic airway diseases has been suggested by several studies, but direct evidence to support the link between acute Cpneumoniae infection and new-onset asthma is insufficient. OBJECTIVES: To determine the association between C. pneumoniae infection and subsequent bronchial hyperresponsiveness (BHR) and hence asthma. METHODS: We studied 110 Thai military conscripts during an epidemic of Cpneumoniae infection in Thailand, from November 1, 1998, through February 28, 1999. The diagnosis was based on a standardized microimmunofluorescence technique. Spirometry and methacholine challenge tests (MCTs) were conducted. This cohort study excluded all conscripts with preexisting positive MCTs. RESULTS: Ninety-three percent of the conscripts presented with an acute cough of a mean duration of 15.2 days. The pattern of serologic response revealed that 83% had acute primary infections and 10% had acute reinfections. Mean forced expiratory volume in 1 second was 99.5%, with an improvement of 1.8% after bronchodilator administration. Only 3.6% revealed small airways disease (forced expiratory flow between 25% and 75% of <65%) on spirometry. Methacholine challenge tests failed to demonstrate BHR in all conscripts, and none had developed a new-onset wheeze (physician-diagnosed asthma) at up to 2 years of follow-up. CONCLUSIONS: This study demonstrates that cough in patients with acute primary Cpneumoniae infection is not associated with BHR among previously healthy adults. The pathogenetic mechanism by which organisms cause coughing and wheezing in acute bronchitis seems to be different among causative respiratory pathogens.

A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients.

In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFC MDI at 20.1%. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers.

Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.

BACKGROUND: Psychological disorders were originally thought to be the sole cause of vocal cord dysfunction (VCD). Subsequently, other organic diseases, including structural laryngeal abnormalities, have also been reported to be associated with VCD. OBJECTIVES: To describe the first patient with VCD concurrent with a nutcracker esophagus and to establish the association between VCD and gastroesophageal reflux disease (GERD) by using the Bernstein test. METHODS: Symptom assessments, neuropsychiatric evaluations, fiberoptic laryngoscopy, pulmonary function tests, allergic skin prick tests, radiographs of the chest and sinuses, esophageal manometry (including 24-hour ambulatory esophageal pH monitoring), and the Bernstein test were performed. RESULTS: A 36-year-old woman had dyspnea, hoarseness, chest pain, and wheezes without relief for a decade. Neuropsychiatric evaluations disclosed mild depression. Fiberoptic laryngoscopy showed posterior laryngitis and paradoxical vocal cord adduction with audible inspiratory stridor. Pulmonary function tests showed attenuation of the inspiratory limb with notching in both flow-volume loops and a mid-vital capacity expiratory to inspiratory flow ratio of 4. All the symptoms except chest pain were improved dramatically by speech therapy and empirical treatment for GERD. Esophageal manometry revealed a nutcracker esophagus; 24-hour ambulatory esophageal pH monitoring demonstrated multiple short reflux episodes. The Bernstein test was conducted, and all the manifestations were reproduced with 0.1 N hydrochloric acid but not with isotonic sodium chloride infusion. CONCLUSIONS: This is the first human case report confirming that GERD can trigger an acute attack of VCD and may induce chest pain as a nutcracker esophagus in patients with VCD. It strengthens this association and expands our knowledge of diverse manifestations of this clinical entity.