Retrograde Ureteral Stents versus Percutaneous Nephrostomy in the Management of Malignant Ureteral Obstruction: A Systematic Review and Meta-Analysis.

OBJECTIVE: To evaluate outcomes in cancer patients with ureteral obstruction by comparison of retrograde stenting and percutaneous nephrostomy techniques. METHODS: Systematic review of all studies up to October 2023. Studies were identified from all major databases including MEDLINE, Cochrane, and EMBASE. All comparative studies between retrograde stenting and percutaneous nephrostomy were searched; studies with paediatric populations were excluded. Primary outcomes were procedure and intervention failure rates; secondary outcomes were infection, blockage, displacement and unplanned exchange rates along with procedure time and length of stay. RESULTS: Eighteen studies with 1228 patients contributed to the summative outcome. Percutaneous nephrostomy was statistically superior to retrograde stenting for procedure failure rate (p<0.00001) and intervention failure rate (p=0.0004). Retrograde stenting was statistically superior to percutaneous nephrostomy for displacement rates (p=0.003), procedure time (p<0.00001) and length of stay (p<0.00001). Retrograde stenting showed no difference to percutaneous nephrostomy for infection rates (p=0.94), blockage rates (p=0.93), unplanned exchange rates (p=0.48), CONCLUSION: There is no absolute superiority for retrograde stenting or percutaneous nephrostomy for malignant ureteral obstruction. Both techniques have their advantages and disadvantages, with some comparable outcomes; patients are key when selecting the best technique. Larger studies are required to assess the outcomes of both techniques.

Surgical innovation revisited: A historical narrative of the minimally invasive "Agarwal sliding-clip renorrhaphy" technique for partial nephrectomy and its application to an Australian cohort.

Objective: To evaluate local clinical outcomes of sliding clip renorrhaphy, from inception to current utilization for open, laparoscopic, and robotically assisted partial nephrectomy. Methods: We reviewed prospectively maintained databases of three surgeons performing partial nephrectomies with the sliding-clip technique at teaching hospitals between 2005 and 2019. Baseline characteristics, operative parameters, including surgical approach, RENAL Nephrometry Score, and post-operative outcomes, including Clavien-Dindo classification of complications, were recorded for 76 consecutive cases. We compared perioperative and 90-day events with patient and tumor characteristics, stratified by operative approach and case complexity, using Wilcoxon rank-sum test for continuous variables and the Chi-squared or Fisher's exact test, for binary and categorical variables, respectively. Results: Open surgery (n = 15) reduced ischemia time and operative time, but increased hospital admission time. Pre- and post-operative estimated glomerular filtration rates did not change significantly by operative approach. Older patients (P = .007) and open surgery (P = .003) were associated with a higher rate of complications (any-grade). Six grade ≥3 complications occurred: these were associated with higher RENAL Nephrometry Score (P = .016) and higher pathological tumor stage (P = .045). Limits include smaller case volumes which incorporate the learning curve cases; therefore, these data are most applicable to lower volume teaching hospitals. Conclusion: The sliding-clip technique for partial nephrectomy was first described by Agarwal et al and has low complication rates, acceptable operative time, and preserves renal function across open and minimally invasive surgeries. This series encompasses the initial learning curve with developing the technique through to present-day emergence as a routine standard of practice.

Radial nerve palsy in humeral shaft fractures with internal fixation: analysis of management and outcome.

INTRODUCTION: The incidence of radial nerve injury after humeral shaft fractures is on average 11.8% (Shao et al., J Bone Jt Surg Br 87(12):1647-1652, 2005) representing the most common peripheral nerve injury associated with long bone fractures (Korompilias et al., Injury, 2013). The purpose of this study was to analyze our current policy and long-term outcome, regarding surgically treated humeral shaft fractures in combination with radial nerve palsy. MATERIALS AND METHODS: We retrospectively analyzed the data of patients with surgically treated humeral shaft fractures from 01/01/2003 to 28/02/2013. The analysis included fracture type, soft tissue injury regarding closed and open fractures, type of fixation, management, and outcome of radial nerve palsy. RESULTS: A total of 151 humeral shaft fractures were fixed in our hospital. In 20 (13%) cases, primary radial palsy was observed. Primary nerve exploration was performed in nine cases. Out of the 13 patients with follow-up, 10 showed a complete, 2 a partial, and 1 a minimal nerve recovery. Two of them underwent a revision procedure. Secondary radial nerve palsy occurred in 9 (6%) patients postoperatively. In five patients, the radial nerve was not exposed during the initial surgery and, therefore, underwent revision with nerve exploration. In all 5, a potential cause for the palsy was found and corrected as far as possible with full recovery in 3 and minimal recovery in one patient. In four patients with exposure of the nerve during the initial surgery, no revision was performed. All of these 4 showed a full recovery. CONCLUSION: Our study showed an overall rate of 19% radial nerve palsy in surgically treated humeral shaft fractures. Most of the primary palsies (13%) recovered spontaneously, and therefore, nerve exploration was only exceptionally needed. The incidence of secondary palsy after surgery (6%) was high and mainly seen after plate fixation. In these cases, we recommend early nerve exploration, to detect and treat potential curable neural lesions.

[Solitary pulmonary nodule on CT - observation or surgical resection?]. / Lungenrundherd im CT - Beobachten oder resezieren?

Incidentally found solitary pulmonary nodules (SPN) are increasing due to liberal use of high resolution CT scans. SPNs are defined as densities up to 3cm without associated enlarged lymph nodes. Morphologic patterns of the SPN in CT or dynamic changes in serial investigations as well as the individual risk profile (age, smoking history, current or past malignant disease) are crucial to classify the likelihood of malignancy as low, intermediate or high. Whereas low risk SPNs have to be observed by serial CT scans, intermediate risk SPNs have to be evaluated by transthoracic or bronchoscopic biopsies. However, these investigations are only reliable if malignant or specific benign diseases can be clearly diagnosed in the obtained tissue. In all the other cases, SPNs remain undetermined and surgical resection is mandatory. Increasingly, FDG-PET is performed in patients with intermediate risk SPNs and a high risk for surgery aiming to further determine the pre-test probability of malignant disease. Its sensitivity is about 80%. Nodules with high FDG uptake are suspect to be malignant and surgical removal is indicated. SPN with a high likelihood to be malignant are usually resected surgically as a primary approach. In case of metastasis, excisional biopsy may be therapeutic. The surgical method of choice is the video assisted thoracoscopic (VATS) wedge resection. Ideal for this method are nodules of 1 to 2 cm in diameter not localised deeper within lung parenchyma than its own diameter. If a SPN is diagnosed intraoperatively to be a non-small cell lung cancer, anatomic resection can be performed under the same anaesthesia. SPNs diagnosed to be cancer often are early stage tumours. Therefore, lobectomy and lymphadenectomy can also be made in VATS technique. In rare cases, diagnostic thoracotomy may still be necessary to definitely determine the aetiology of a SPN. An interdisciplinary approach is crucial to plan an efficient and individualised work-up of SPNs.

Challenging narrow distal aorta in abdominal aortic aneurysm--endovascular repair using a reversed flared endoprosthesis.

INTRODUCTION: Narrow aortic bifurcations are a challenging issue while treating abdominal aortic aneurysm by endovascular means. Off-the-shelf products are often not suitable and special considerations and custom-made endoprostheses are necessary. REPORT: Alternatively, some morphologies qualify for a flared tube graft. We report two successful aneurysm exclusions using custom-made (Anaconda, Vascutek/Terumo) step-down diameter grafts in patients with tight distal aortas without the need for pre-interventional endograft adjustments. DISCUSSION: In these two cases, implantation of a custom-made proximally flared tube endograft in treating a localised abdominal aortic aneurysm with a narrow and calcified bifurcation seems feasible. They represent uncommon, yet challenging, issues worthy of attention.

[Acute bleeding from the innominate artery after removal of percutaneous tracheotomy]. / Akute Truncus-brachiocephalicus-Blutung nach Entfernung einer perkutanen Dilatationstracheotomie.

Percutaneous tracheotomy is a standard procedure in intensive care units. Even though complications associated with this intervention have been described, acute massive bleeding from the innominate artery is rare and necessitates immediate intervention. We report a case with acute bleeding after removal of a percutaneous tracheotomy cannula.

Intraoperative duplex ultrasonography in carotid endarterectomy: the impact on indication for immediate revision and intermediate-term outcome.

BACKGROUND: Thromboembolic complications in relation to carotid endarterectomies (CEA) are frequently associated with technical errors. We analyzed prospectively the impact of intraoperative duplex ultrasonography (IODS) in CEA on immediate revision and postoperative results. PATIENTS AND METHODS: We have observed 70 patients with 74 CEA. Indications for surgery were asymptomatic high grade stenosis (70-99%) or symptomatic stenosis of > 50%. IODS findings were rated as "relevant", "minor" or "normal". Relevant findings were immediately repaired. Peri- and postoperative neurological events were analyzed in Duplex Scans controls in a median length of follow-up of 17.3 months. Outcome of patients with "minor" findings (group A) were compared with patients having "normal" or corrected "relevant" findings (group B). RESULTS: In 8/74 cases (11%) we found relevant findings leading to immediate revision. In 25/74 (34%) cases minor findings were detected which were not revised. In group A (n = 25, 34%) two asymptomatic occlusions and one recurrent high grade stenosis were found during follow-up. In group B (n = 49, 66%) we detected two high and two low grade stenosis. The 30 day death and stroke rate was 1.4% (n = 1). CONCLUSIONS: IODS is a sensitive method to detect immediately pathological findings. Its correction seems to reduce the incidence of early occlusions and therefore early neurological events.

In vivo mechanical characterization of human liver.

The mechanical behavior of human liver has been characterized with aspiration experiments. Measurements have been performed in vivo under sterile conditions during open surgery. Twenty-three measurements on six healthy human livers were performed using the same loading history for each test, so to allow a direct comparison of the measured deformations. The measurement results are reported and the experimental uncertainties evaluated. One of the main objectives of the present paper is to share information on the in vivo mechanical response of human liver with the biomechanics research community: the present data can be used for mechanical model development and validation purposes. The parameters of a quasi-linear viscoelastic model have been determined from the experimental data by means of inverse finite element calculations. The corresponding linear elastic modulus is compared with values from the literature. In particular, a significant discrepancy has been found with respect to the values proposed by Carter et al. [Carter, F.J., Frank, T.G., Davies, P.J., McLean, D., Cuschieri, A., 2001. Measurement and modelling of the compliance of human and porcine organs. Medical Image Analysis 5, 231-236] and the reasons for this difference are discussed. The predictive capabilities of the quasi-linear viscoelastic model and the Rubin Bodner non-linear elastic-viscoplastic model are compared with respect to the tissue response in repeated aspiration cycles. Finally, for demonstration purposes, the constitutive model corresponding to the "average" liver response has been implemented into a finite element whole liver model and used for simulations related to liver surgery.

Prognostic factors affecting long-term outcomes in patients with resected stage IIIA pN2 non-small-cell lung cancer: 5-year follow-up of a phase II study.

The aim was to investigate the efficacy of neoadjuvant docetaxel-cisplatin and identify prognostic factors for outcome in locally advanced stage IIIA (pN2 by mediastinoscopy) non-small-cell lung cancer (NSCLC) patients. In all, 75 patients (from 90 enrolled) underwent tumour resection after three 3-week cycles of docetaxel 85 mg m-2 (day 1) plus cisplatin 40 or 50 mg m-2 (days 1 and 2). Therapy was well tolerated (overall grade 3 toxicity occurred in 48% patients; no grade 4 nonhaematological toxicity was reported), with no observed late toxicities. Median overall survival (OS) and event-free survival (EFS) times were 35 and 15 months, respectively, in the 75 patients who underwent surgery; corresponding figures for all 90 patients enrolled were 28 and 12 months. At 3 years after initiating trial therapy, 27 out of 75 patients (36%) were alive and tumour free. At 5-year follow-up, 60 and 65% of patients had local relapse and distant metastases, respectively. The most common sites of distant metastases were the lung (24%) and brain (17%). Factors associated with OS, EFS and risk of local relapse and distant metastases were complete tumour resection and chemotherapy activity (clinical response, pathologic response, mediastinal downstaging). Neoadjuvant docetaxel-cisplatin was effective and tolerable in stage IIIA pN2 NSCLC, with chemotherapy contributing significantly to outcomes.

[Acute vascular occlusion of the upper extremity after blunt trauma]. / Akuter Gefässverschluss der oberen Extremität nach stumpfem Trauma.

Intimal ruptures after blunt trauma without joint dislocation are rare. We report the case of a 62 year old male patient presenting with paraesthesia in the fingers I to III and a cool left hand after a blunt trauma of the upper arm. Non-invasive examination documented the thrombotic occlusion of the axillary artery. Due to a circular rupture of the intima surgical revascularization was performed with a vein graft.

[First experience with a critical incident reporting system in surgery]. / Critical incident reporting system. Erste Erfahrungen in der Chirurgie.

Systems that record critical incidents were initially developed for aeronautics and are being increasingly applied in medicine. The objective is to detect problems inherent to systems and system errors before they lead to complications or do harm to patients. We report our preliminary experience with a critical incident reporting system (CIRS). Since February 1 2001, all employees of our surgical department have been able to report incidents, anonymously or candidly, to a central board using a standardized documentation form. The results are presented at monthly internal quality meetings, where two to three crucial incidences are thoroughly discussed. New information is communicated and put into practice as quickly as possible. A total of 424 incidents were reported from February 1, 2001 to December 31, 2003. Reversible damages, some of which resulted in prolonged hospitalization, were consequential to 22% of the cases. Thirteen percent were classified as "near miss" (almost incidents), whereas 65% had no consequences for patients. As expected, doctors and nurses were most frequently involved, as 36% of the reported incidents occurred in connection with the prescription and administration of medication. In particular, the near miss category revealed system errors which in 85% of cases had immediate consequences for therapeutic procedures. Based on our initial experiences, working with CIRS may be evaluated as positive. The open discussion of incidents and errors also revealed minor but often significant system errors, which resulted in alteration of our internal proceedings and thus improved the quality and safety of treatment.

[The role of video-thoracoscopy in thoracic surgery]. / Video-thorakoskopische Eingriffe--was hat sich durchgesetzt.

The widespread acceptance of minimal invasive techniques has revolutionized the practice of surgery including, thoracic surgery. Within a short period of time, video-assisted thoracic surgery (VATS) has become an acceptable approach to a wide range of thoracic procedures. The use of VATS as a diagnostic modality is now well established. For therapeutic procedures, VATS has also been generally accepted as the treatment for spontaneous pneumothorax, thoracic sympathectomy, treatment of loculated effusions and resection of simple mediastinal cysts and benign tumors. Its role in major procedures, e.g. anatomic lung resections and thymectomy, however, remain poorly defined at present although some of the existing intermediate results are encouraging. The technique continues to evolve, with further miniaturization to reduce access-induced trauma. No matter how attractive the new techniques may appear, carefully conducted clinical trials should precede the general acceptance and widespread use.

[Severe heart failure: treatment optimisation and monitoring using plasma NT-proBNP levels--an useful tool in clinical practice]. / Schwere Herzinsuffizienz: Therapieoptimierung/Therapie monitorisierung mittels NT-proBNP-Plasmaspiegels--ein lohnendes Werkzeug für die Praxis.

A young patient presented with a cardiomegaly of unknown origin. The cardiologic examination revealed a severe eccentric left ventricular hypertrophy and a dilatation of the other heart cavities as well as a strongly impaired global systolic function. The patient was treated with an ACE inhibitor, a diuretic and with a beta-blocking agent. The dosages of which were adapted accordingly to the plasma concentration of N-terminal-pro-brain-natriuretic peptide (NT-proBNP). After five months of treatment, a decrease of the NT-proBNP level to nearly normal values along with a significant reduction of the heart dimensions and a substantial improvement of left ventricular function were found.

[Surgical management of abdominal aortic aneurysms with coexistent intestinal disease]. / Koinzidenz eines Bauchaortenaneurysmas mit Pathologien viszeraler Hohlorgane. Chirurgisches Vorgehen bei hoher therapeutischer Dringlichkeit.

The management of patients suffering from abdominal aortic aneurysms with concomitant intestinal disease is demanding. Surgical procedures have to be evaluated meticulously with regard to morbidity and priority. We retrospectively investigated early and late results of nine patients (eight males, one female) with coincidental aortic and intestinal surgery during the last 9.5 years. The average age was 77 years (range 67-85). One-stage procedures were undertaken twice with implantation of aortic grafts to replace abdominal aortic aneurysms (AAA). During these emergency procedures, an aortoduodenal fistula was repaired in one case and resection of an ischemic segment of the sigmoid colon was resected in another. Seven two-stage procedures were performed as elective surgery. Five AAA were excluded before the intestinal repair. In two cases of urgent visceral pathologies, colon resection was done first, followed by elimination of the AAA. In case of elective surgery, two-stage procedures seem to be safe and effective. However, in certain emergent cases, one-stage procedures with implantation of vascular grafts in combination with colon or bowel surgery might also be justified.

[How often do surgical residents operate in a category A non-university post-graduate teaching hospital?]. / Wie oft operieren chirurgische Facharztanwärter an einer nicht-universitären Weiterbildungsstätte der Kategorie A?

INTRODUCTION: After introduction of the new postgraduate training program for general surgery the completion of the operation list still represents the most important step. Based on our number of operations we examined whether residents would carry out the requested interventions at our non-university teaching hospital (category A). METHOD: For eight tracer operations we retrospectively counted the number of cases of the non private patients from 1998-2002 and took account of the postgraduate education status of the operator. In this period the team consisted of 51 residents (71 education years), of whom 18 candidates for general surgery who carried out the interventions (35 education years, inclusive rotation in ICU, emergency room and special surgical disciplines). RESULTS: Regarding all tracer operations, the amount of interventions per year and candidate which are necessary to accomplish the goal for the first four years of education are reached: appendectomy 8.9, laparoscopic cholecystectomy 7.3, open inguinal hernia repair 9.4, varicose veins operation 12.1, open colon sigmoideum resection 3.2, hip and malleolar fracture 6.9, hemithyreoidectomy 5. CONCLUSION: Completion of the operation list as the major training goal was reached at our institution. Following our structured education program the demands regarding postgraduate education will be met also in future. Further studies however, must examine the impact of the new resident's work contracts dictating a reduction of the weekly working hours.

[Merkel cell carcinoma. Retrospective analysis of 4 cases with special reference to diagnosis, therapy and long-term outcome]. / Das Merkelzellkarzinom. Retrospektive Analyse von vier Fällen unter spezieller Berücksichtigung der Diagnostik, der Therapie und des Langzeitverlaufes.

BACKGROUND: Merkel cell carcinoma is an aggressive neuro-endocrine skin tumor with early regional lymph node involvement and early distant metastases. Diagnostic work-up may be difficult because of the low incidence of the tumor. Treatment concepts are individual and long-term-outcome are varying markedly. METHODS: Retrospective analyse of four cases with special regard to the diagnostic, therapeutic approach and the long-term follow-up. RESULTS: In every case diagnosis has only been made histologically. In the first patient, suffering from a tumor on the upper arm, after the tumor removal, local and axillary radiotherapy has been performed. In a second case with an extended tumor on the shank, a palliative tumor-debulking was followed by a chemo- and radiotherapy. The third Patient had a tumor in the gluteal region with involvement of the regional lymph nodes. He was treated by a complete surgical excision and lymphadenectomy followed by a local radiotherapy with subsequent chemotherapy. The fourth patient with tumor on the elbow, without lymph node involvement, refused surgical intervention, therefore she has been treated by radio- and chemotherapy. All patients are respectively 1.2 and 3 years are alive without evidence of recurrence. One patient died after 1.5 year because of tumor relapse. CONCLUSION: Diagnosis of Merkel cell carcinoma is difficult and is established only by in- or excision biopsy of the tumor. If ever possible surgical excision combined with regional lymphadenectomy should be performed. Adjuvant radiotherapy is established, whereas the value of chemotherapy has not yet be defined and might be beneficial only in cases of expansive or disseminated growth. In our series we did encounter the often described metastatic involvement of other organs just in one case.

[Bilateral popliteal artery entrapment syndrome. Is preventive operation on the asymptomatic side indicated?]. / Das bilaterale arterielle popliteale Entrapmentsyndrom. Ist die präventive Operation der asymptomatischen Gegenseite indiziert?

Popliteal artery entrapment is a rare cause of claudication symptoms, but should always be included in the differential diagnosis of lower limb ischaemia in young patients, especially men. On an embryological basis, PAES is the result of the abnormal development of the popliteal artery or the gastrocnemius muscle. The anomaly is manifested as one of four types. Untreated, the entrapment results in the deterioration of the artery, resulting in eventual occlusion. Presenting the case of a 37 year old female patient with bilateral PAES and a review of the literature we discuss the clinical findings, diagnosis, treatment options and the management of the often asymptomatic opposite side.