RESUMEN
BACKGROUND: Congenital glioblastoma (cGBM) is a brain tumor very rarely observed in newborns and young infants, and differs in several respects from glioblastoma (GBM) of childhood and adulthood. Our aim was the presentation of a cGBM case with 14 days of postnatal survival at the Pediatric Oncology Center of the Markusovszky University Teaching Hospital in 2004. We investigated formalin-fixed, paraffin-embedded autoptic tumor samples of the newborn by immunohistochemical and molecular genetic (FISH and pyrosequencing) methods. We found polysomy of chromosome 2 and 5' deletion of the ALK gene in the glioma cells by ALK FISH. This result indicates the importance of molecular analyses in the diagnostic evaluation of cGBM, and raises the possibility of a personalized, targeted therapy (crizotinib, alectinib).
Asunto(s)
Neoplasias Encefálicas , Glioblastoma , Adulto , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/terapia , Crizotinib , Glioblastoma/congénito , Glioblastoma/genética , Glioblastoma/patología , Humanos , Recién Nacido , Proteínas Tirosina Quinasas Receptoras/genéticaAsunto(s)
Criptococosis/microbiología , Cryptococcus , Dermatomicosis/microbiología , Dermatosis Facial/microbiología , Dermatosis de la Mano/microbiología , Dermatosis del Cuero Cabelludo/microbiología , Anciano de 80 o más Años , Antifúngicos/uso terapéutico , Criptococosis/diagnóstico , Dermatomicosis/diagnóstico , Dermatosis Facial/diagnóstico , Fluconazol/uso terapéutico , Dermatosis de la Mano/diagnóstico , Humanos , Masculino , Dermatosis del Cuero Cabelludo/diagnósticoRESUMEN
Authors present a rare manifestation of the temporal arteritis, wich caused initial diagnostic difficulties, but it responded well for corticosteroid treatment. The features of the disease, pathogenesis, possible therapy are briefly summarized beside the description of clinical course. Orv. Hetil., 2017, 158(2), 77-80.