RESUMEN
In this paper the physiological role of NO and isoforms of NOS in the gastrointestinal tract and the involvement of NO in pathological processes of digestive tract as well as the perspective of therapeutic use of NO-donating drugs and selective inhibitors of phosphodiesterase in the treatment of gastric diseases were presented.
Asunto(s)
Tracto Gastrointestinal/fisiología , Tracto Gastrointestinal/fisiopatología , Óxido Nítrico/metabolismo , Gastropatías/patología , Gastropatías/fisiopatología , Animales , Inhibidores Enzimáticos/química , Inhibidores Enzimáticos/farmacología , Tracto Gastrointestinal/metabolismo , Tracto Gastrointestinal/patología , Humanos , Isoenzimas/antagonistas & inhibidores , Isoenzimas/fisiología , Óxido Nítrico/química , Donantes de Óxido Nítrico/metabolismo , Donantes de Óxido Nítrico/uso terapéutico , Óxido Nítrico Sintasa/antagonistas & inhibidores , Óxido Nítrico Sintasa/metabolismo , Gastropatías/tratamiento farmacológicoRESUMEN
The free radicals derived from oxygen have been implicated in damage caused to the gastroduodenal mucosa. The association between the mucosal production of reactive oxygen radicals in the gastric antrum and duodenum, Helicobacter pylori density and duodenal ulcer has been previously described. The role of interleukin IL-8 in the inflammatory process and its relationship with reactive oxygen radicals has also been investigated. These results indicate that oxygen radicals play an important role in the mechanism of ulcer aggravation induced by a variety of different factors.
Asunto(s)
Úlcera Duodenal/fisiopatología , Gastroenteritis/fisiopatología , Especies Reactivas de Oxígeno/fisiología , Úlcera Gástrica/fisiopatología , Úlcera Duodenal/microbiología , Duodeno/metabolismo , Radicales Libres/metabolismo , Mucosa Gástrica/metabolismo , Helicobacter pylori/aislamiento & purificación , Humanos , Interleucina-8/metabolismo , Úlcera Gástrica/microbiologíaRESUMEN
Authors discussed etiology, diagnostic and therapeutical problems in the treatment of primary gastric non-Hodgkin lymphoma. The first one was limited to the gastric region and was cured favourably. The second one extended gastric region and affected all alimentary tract. This case was terminated by death of the patient.
Asunto(s)
Linfoma no Hodgkin , Neoplasias Gástricas , Anciano , Resultado Fatal , Femenino , Humanos , Linfoma no Hodgkin/diagnóstico , Linfoma no Hodgkin/etiología , Linfoma no Hodgkin/terapia , Persona de Mediana Edad , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/etiología , Neoplasias Gástricas/terapiaRESUMEN
During recent years, gastric ECL cells have attracted much attention, mainly due to the fact that mice and rats were found to develop gastric carcinoids following lifelong treatment with blockers of acid secretion. We present the structure and functions of ECL cells and their influence on physiology and pathology of stomach and duodenum. We describe interactions of enzymes and hormones in histamine-stimulated gastric output.