Tibial spine volume is smaller in ACL-injured athletes compared to healthy athletes.

PURPOSE: The aim of this study was to investigate whether the whole tibial spine volume and femoral intercondylar notch volume are risk factors for anterior cruciate ligament (ACL) injury. The hypothesis was that the whole tibial spine volume and femoral notch volume would be smaller in athletes who sustained ACL injury than in athletes with no history of ACL injury. METHODS: Computed tomography scans of both knees were acquired and three-dimensional bone models were created using Mimics to measure whole tibial spine volume and femoral notch volume. Tibial spine volume, femoral notch volume and each of these volumes normalised by tibial plateau area were compared between the ACL-injured and the ACL-intact group. RESULTS: Fifty-one athletes undergoing unilateral anatomical ACL reconstruction (17 female, 34 male: average age 22.0 ± 7.5) and 19 healthy collegiate athletes with no previous knee injury (eight female, 11 male: average age 20.1 ± 1.3) were included in this study. The whole tibial spine volume in the ACL-injured group (2.1 ± 0.5 cm3) was 20.7% smaller than in the ACL-intact group (2.7 ± 0.7 cm3) (p = 0.005). No differences were observed between the femoral notch volume in the ACL-injured group (9.5 ± 2.1 cm3) and the ACL-intact group (8.7 ± 2.7 cm3) (n.s.). CONCLUSIONS: The main finding of this study was that the whole tibial spine volume of the ACL-injured group was smaller than the ACL-intact group. A small tibial spine volume can be added to the list of anatomical risk factors that may predispose athletes to ACL injury. LEVEL OF EVIDENCE: Level Ⅲ.

Improved joint function when reaching behind the back is associated with patient reported outcomes in individuals with rotator cuff tears following exercise therapy.

BACKGROUND: Reaching behind the back is painful for individuals with rotator cuff tears. The objectives of the study were to determine changes in glenohumeral kinematics when reaching behind the back, passive range of motion (RoM), patient reported outcomes and the relationships between kinematics and patient reported outcomes following exercise therapy. METHODS: Eighty-four individuals with symptomatic isolated supraspinatus tears were recruited for this prospective observational study. Glenohumeral kinematics were measured using biplane radiography during a reaching behind the back movement. Passive glenohumeral internal rotation and patient reported outcome measures were collected. Depending on data normality, appropriate tests were utilized to determine changes in variables. Spearman's correlations were utilized for associations, and Stuart-Maxwell tests for changes in distributions. FINDINGS: Maximum active glenohumeral internal rotation increased by 3.2° (P = 0.001), contact path length decreased by 5.5% glenoid size (P = 0.022), passive glenohumeral internal rotation RoM increased by 4.9° (P = 0.001), and Western Ontario Rotator Cuff Index and American Shoulder and Elbow Surgeons scores increased by 29.8 and 21.1 (P = 0.001), respectively. Changes in Western Ontario Rotator Cuff Index scores positively associated with changes in maximum active glenohumeral internal rotation and negatively associated with changes in contact path lengths (P = 0.008 and P = 0.006, respectively). INTERPRETATION: The reaching behind the back movement was useful in elucidating in-vivo mechanistic changes associated with patient reported outcomes. Glenohumeral joint function and patient reported outcomes improved, where changes in Western Ontario Rotator Cuff Index scores were associated with kinematics. These findings inform clinicians of functional changes following exercise therapy and new targetable treatment factors.

Ankle and subtalar joint axes of rotation and center of rotation during walking and running in healthy individuals measured using dynamic biplane radiography.

The goal of this study was to determine how foot type and activity level affect ankle and hindfoot motion. Dynamic biplane radiography and a validated volumetric registration process was used to measure ankle and hindfoot motion of 20 healthy adults during walking and running. The helical axes of motion (HAM) during stance were calculated at the tibiotalar and subtalar joints. The intersection of each HAM and the rotation plane of interest defined the tibiotalar and subtalar centers of rotation (COR). Correlations between foot type and hindfoot kinematics were calculated using Pearson's correlations. The effect of activity, phase of gait, and dominant vs. non-dominant limb on HAM and COR were evaluated using linear mixed effects models. Activity and phase of gait influenced the superior location of the tibiotalar (p < 0.041) and subtalar (p < 0.044) CORs. Activity and gait phase affected tibiotalar (p < 0.049) and subtalar (p < 0.044) HAM direction during gait. Both HAM orientation and COR location changed with activity and phase of gait. These ankle and hindfoot kinematics have implications for total ankle replacement design and musculoskeletal models that estimate force and moment generating capabilities of muscles.

Bone morphology features associated with knee kinematics may not be predictive of ACL elongation during high-demand activities.

PURPOSE: Bony morphology has been proposed as a potential risk factor for anterior cruciate ligament (ACL) injury. The relationship between bony morphology, knee kinematics, and ACL elongation during high-demand activities remains unclear. The purpose of this study was to determine if bone morphology features that have been associated with ACL injury risk and knee kinematics are also predictive of ACL elongation during fast running and double-legged drop jump. METHODS: Nineteen healthy athletes performed fast running and double-legged drop jump within a biplane radiography imaging system. Knee kinematics and ACL elongation were measured bilaterally after using a validated registration process to track bone motion in the radiographs and after identifying ACL attachment sites on magnetic resonance imaging (MRI). Bony morphological features of lateral posterior tibial slope (LPTS), medial tibial plateau (MTP) depth, and lateral femoral condyle anteroposterior width (LCAP)/lateral tibial plateau anteroposterior width (TPAP) were measured on MRI. Relationships between bony morphology and knee kinematics or ACL elongation were identified using multiple linear regression analysis. RESULTS: No associations between bony morphology and knee kinematics or ACL elongation were observed during fast running. During double-legged drop jump, a greater range of tibiofemoral rotation was associated with a steeper LPTS (ß = 0.382, p = 0.012) and a deeper MTP depth (ß = 0.331, p = 0.028), and a greater range of anterior tibial translation was associated with a shallower MTP depth (ß = - 0.352, p = 0.018) and a larger LCAP/ TPAP (ß = 0.441, p = 0.005); however, greater ACL elongation was only associated with a deeper MTP depth (ß = 0.456, p = 0.006) at toe-off. CONCLUSION: These findings indicate that observed relationships between bony morphology and kinematics should not be extrapolated to imply a relationship also exists between those bone morphology features and ACL elongation during high-demand activities. These new findings deepen our understanding of the relationship between bony morphology and ACL elongation during high-demand activities. This knowledge can help identify high-risk patients for whom additional procedures during ACL reconstruction are most appropriate.

Symmetry in knee arthrokinematics in healthy collegiate athletes during fast running and drop jump revealed through dynamic biplane radiography.

OBJECTIVE: Changes in cartilage contact area and/or contact location after knee injury can initiate and exacerbate cartilage degeneration. Typically, the contralateral knee is used as a surrogate for native cartilage contact patterns on the injured knee. However, symmetry in cartilage contact patterns between healthy knees during high-impact activities is unknown. METHOD: Tibiofemoral kinematics were measured on 19 collegiate athletes during fast running and drop jump using dynamic biplane radiography and a validated registration process that matched computed tomography (CT)-based bone models to the biplane radiographs. Cartilage contact area and location were measured with participant-specific magnetic resonance imaging (MRI)-based cartilage models superimposed on the CT-based bone models. Symmetry in cartilage contact area and location was assessed by the absolute side-to-side differences (SSD) within participants. RESULTS: The SSD in contact area during running (7.7 ± 6.1% and 8.0 ± 4.6% in the medial and lateral compartments, respectively) was greater than during drop jump (4.2 ± 3.7% and 5.7 ± 2.6%, respectively) (95% CI of the difference: medial [2.4%, 6.6%], lateral [1.5%, 4.9%]). The average SSD in contact location was 3.5 mm or less in the anterior-posterior (AP) direction and 2.1 mm or less in the medial-lateral (ML) direction on the femur and tibia for both activities. The SSD in AP contact location on the femur was greater during running than during drop jump (95% CI of the difference: medial [1.6 mm, 3.6 mm], lateral [0.6 mm, 1.9 mm]). CONCLUSION: This study provides context for interpreting results from previous studies on tibiofemoral arthrokinematics. Previously reported differences between ligament-repaired and contralateral knee arthrokinematics fall within the range of typical SSDs observed in healthy athletes. Previously reported arthrokinematics differences that exceed SSDs found in these healthy athletes occur only in the presence of anterior cruciate ligament (ACL) deficiency or meniscectomy.

How Many Trials Are Needed to Estimate Typical Lumbar Movement Patterns During Dynamic X-Ray Imaging?

Dynamic biplane radiographic (DBR) imaging measures continuous vertebral motion during in vivo, functional tasks with submillimeter accuracy, offering the potential to develop novel biomechanical markers for lower back disorders based on true dynamic motion rather than metrics based on static end-range of motion. Nevertheless, the reliability of DBR metrics is unclear due to the inherent variability in movement over multiple repetitions and a need to minimize radiation exposure associated with each movement repetition. The objectives of this study were to determine the margin of uncertainty (MOU) in estimating the typical intervertebral kinematics waveforms based upon only a small number of movement repetitions, and to determine the day-to-day repeatability of intervertebral kinematics waveforms measured using DBR. Lumbar spine kinematics data were collected from two participant groups who performed multiple trials of flexion-extension or lateral bending to assess the uncertainty in the mean estimated waveform. The first group performed ten repetitions on the same day. Data from that group were used to estimate MOU as a function of the number of repetitions. The second group performed five repetitions on each of two separate days. MOU was not only movement-specific, but also motion segment-specific. Using just one or two trials yielded a relatively high MOU (e.g., >4 deg or 4 mm), however, collecting at least three repetitions reduced the MOU by 40% or more. Results demonstrate the reproducibility of DBR-derived measurements is greatly improved by collecting at least three repetitions, while simultaneously minimizing the amount of radiation exposure to participants.

How well does intra-operative contact path predict post-operative contact path during activities of daily living after medial unicompartmental knee arthroplasty?

Robot-assisted surgical systems can predict post-operative kinematics based upon intra-operative passive kinematics, planned implant position and alignment, and soft-tissue tension. It is currently unknown how well the intra-operative passive kinematics replicate the post-surgical weight bearing active kinematics. This study compared intra-operative and post-operative tibiofemoral implant contact paths after medial unicompartmental knee arthroplasty (mUKA). Passive intraoperative and active postoperative tibiofemoral contact path data was collected from eight patients who underwent mUKA. Intraoperative contact path data was measured using a navigation system. Postoperative contact path data was measured during walking, chair rise, stair ascent, and stair descent using a biplane radiography system and a validated tracking process. A total of 86 movement trials were included in the analysis. The contact point on the femur implant was up to 9.8 mm more medial and up to 8.3 mm less anterior at low flexion angles during activities of daily living than during passive extension intra-operatively, and the contact point on the tibia implant was up to 13.8 mm less lateral and up to 5.8 mm less posterior at low flexion angles during activities of daily living than during intra-operative passive extension. Femoral contact paths primarily differed between 3° and 42° of flexion; and tibial contact paths differed between 3° and 50° of flexion. This pilot study is the first to compare intra-operative and post-operative weight bearing contact paths. The primary conclusions from this study are that contact points on the femur implant are more medial and less anterior at low flexion angles during activities of daily living than during passive extension intra-operatively, and that the contact points on the tibia implant are less lateral at low flexion angles during activities of daily living than during intra-operative passive extension.

Medial Unicompartmental Knee Arthroplasty Restores Native Knee Kinematics During Activities of Daily Living: A Pilot Study.

The ability of unicompartmental knee arthroplasty (UKA) to restore native knee kinematics during activities of daily living remains unclear. The objectives of this prospective study were to identify changes in knee kinematics after medial UKA (mUKA) and to determine if mUKA restores native knee kinematics during activities of daily living. We hypothesized that kinematics are different between the mUKA knee and contralateral knee before surgery, that mUKA restores native knee kinematics, and that mUKA does not affect lateral compartment dynamic joint space. Nine participants performed walking, chair rise, stair ascent and stair descent within a biplane radiography system before and after mUKA. Bilateral knee kinematics were determined for each activity using a validated tracking process that matched subject-specific bones and implants to the biplane radiographs. Compared to contralateral knee, the pre-UKA knee was more adducted (p ≤ 0.019), and more laterally translated (p ≤ 0.008) during all four activities. Additionally, compared to contralateral knee, pre-UKA knee was less internally rotated (p ≤ 0.044) during chair rise and stair ascent. Lateral compartment dynamic joint space did not change during any activity from pre to post mUKA. Our results indicate that mUKA generally restores native kinematics during activities of daily living without altering lateral compartment dynamic joint space.

Posterior tibial slope and meniscal slope correlate with in vivo tibial internal rotation during running and drop jump.

PURPOSE: The relationship between tibial bony and meniscus anatomy and knee kinematics during in vivo, high-impact activities remains unclear. This study aimed to determine if the posterior tibial slope (PTS) and meniscal slope (MS) are associated with in vivo anterior-posterior translation and internal tibia rotation during running and double-leg drop jumps in healthy knees. METHODS: Nineteen collegiate athletes performed fast running at 5.0 m/s on an instrumented treadmill and double-leg drop jump from a 60 cm platform while biplane radiographs of the knee were acquired at 150 Hz. Tibiofemoral kinematics were determined using a validated model-based tracking process. Medial and lateral PTS and MS were measured using magnetic resonance imaging (MRI). RESULTS: In fast running, more internal tibia rotation was associated with greater PTS (ρ = 0.336, P = 0.039) and MS (ρ = 0.405, P = 0.012) in the medial knee compartment. In the double-leg drop jump, more internal tibia rotation was associated with greater PTS (ρ = 0.431, P = 0.007) and MS (ρ = 0.323, P = 0.005) in the medial knee compartment, as well as a greater PTS in the lateral knee compartment (ρ = 0.445, P = 0.005). CONCLUSION: These findings suggest that the medial and lateral PTS and medial MS are associated with the amount of knee rotation during high-impact activities. These in vivo findings improve our understanding of ACL injury risk by linking bone and meniscus morphology to dynamic kinematics.

Validation of dynamic biplane radiography and three-dimensional model-based tracking for evaluation of dynamic thumb kinematics.

Dynamic biplane radiography (DBR) in conjunction with model-based tracking (MBT) has provided a suitable mechanism for biomechanical assessment of many joints but has not yet achieved widespread use at the thumb and wrist. The purpose of this work is to determine the accuracy of DBR with markerless MBT for the evaluation of thumb and wrist joint kinematics. Three 0.6 mm stainless steel beads were implanted into each trapezium, scaphoid, first metacarpal, and radius of three cadaveric upper extremities. Each specimen was manipulated in thumb abduction/adduction, thumb flexion/extension, wrist radioulnar deviation, and wrist flexion/extension while synchronized biplane radiographs were collected at 100 Hz. Specimen-specific 3D bone models were created from CT scans. MBT was performed by optimizing the correlation between digitally reconstructed radiographs, created from the volumetric CT-based bone models, and the biplane radiographs. Joint kinematics and joint space were calculated and compared between the "gold standard" bead-based tracking and markerless MBT. The MBT system accuracy (RMS error) in measuring bone position for the static and dynamic trials was 0.25 mm and 0.58 mm, respectively. The overall MBT system accuracy in measuring dynamic joint kinematics was 1.3 mm in translation and 5.0° in rotation. The MBT system accuracy in measuring dynamic joint space was 0.4 mm. DBR with MBT is a non-invasive and accurate method that can be utilized for kinematic analysis of the thumb and wrist.

Within-subject effects of standardized prosthetic socket modifications on physical function and patient-reported outcomes.

BACKGROUND: Among the challenges of living with lower limb loss is the increased risk of long-term health problems that can be either attributed directly to the amputation surgery and/or prosthetic rehabilitation or indirectly to a disability-induced sedentary lifestyle. These problems are exacerbated by poorly fit prosthetic sockets. There is a knowledge gap regarding how the socket design affects in-socket mechanics and how in-socket mechanics affect patient-reported comfort and function. The objectives of this study are (1) to gain a better understanding of how in-socket mechanics of the residual limb in transfemoral amputees are related to patient-reported comfort and function, (2) to identify clinical tests that can streamline the socket design process, and (3) to evaluate the efficacy and cost of a novel, quantitatively informed socket optimization process. METHODS: Users of transfemoral prostheses will be asked to walk on a treadmill wearing their current socket plus 8 different check sockets with designed changes in different structural measurements that are likely to induce changes in residual limb motion, skin strain, and pressure distribution within the socket. Dynamic biplane radiography and pressure sensors will be used to measure in-socket residual limb mechanics. Patient-reported outcomes will also be collected after wearing each socket. The effects of in-socket mechanics on both physical function and patient-reported outcomes (aim 1) will be assessed using a generalized linear model. Partial correlation analysis will be used to examine the association between research-grade measurements and readily available clinical measurements (aim 2). In order to compare the new quantitative design method to the standard of care, patient-reported outcomes and cost will be compared between the two methods, utilizing the Wilcoxon-Mann-Whitney non-parametric test (aim 3). DISCUSSION: Knowledge on how prosthetic socket modifications affect residual bone and skin biomechanics itself can be applied to devise future socket designs, and the methodology can be used to investigate and improve such designs, past and present. Apart from saving time and costs, this may result in better prosthetic socket fit for a large patient population, thus increasing their mobility, participation, and overall health-related quality of life. TRIAL REGISTRATION: ClinicalTrials.gov NCT05041998 . Date of registration: Sept 13, 2021.

The effect of lateral extra-articular tenodesis on in vivo cartilage contact in combined anterior cruciate ligament reconstruction.

PURPOSE: Lateral extra-articular tenodesis (LET) may confer improved rotational stability after anterior cruciate ligament reconstruction (ACLR). Little is known about how LET affects in vivo cartilage contact after ACLR. The aim of this study was to investigate the effect of LET in combination with ACLR (ACLR + LET) on in vivo cartilage contact kinematics compared to isolated ACLR (ACLR) during downhill running. It was hypothesised that cartilage contact area in the lateral compartment would be larger in ACLR + LET compared with ACLR, and that the anterior-posterior (A-P) position of the contact center on the lateral tibia would be more anterior after ACLR + LET than after ACLR. METHODS: Twenty patients were randomly assigned into ACLR + LET or ACLR during surgery (ClinicalTrials.gov:NCT02913404). At 6 months and 12 months after surgery, participants were imaged during downhill running using biplane radiography. Tibiofemoral motion was tracked using a validated registration process. Patient-specific cartilage models, obtained from 3 T MRI, were registered to track bone models and used to calculate the dynamic cartilage contact area and center of cartilage contact in both the medial and lateral tibiofemoral compartments, respectively. The side-to-side differences (SSD) were compared between groups using a Mann-Whitney U test. RESULTS: At 6 months after surgery, the SSD in A-P cartilage contact center in ACLR + LET (3.9 ± 2.6 mm, 4.4 ± 3.1 mm) was larger than in ACLR (1.2 ± 1.6 mm, 1.5 ± 2.0 mm) at 10% and 20% of the gait cycle, respectively (p < 0.01, p < 0.05). There was no difference in the SSD in cartilage contact center at 12 months after surgery. There was no difference in SSD of cartilage contact area in the medial and lateral compartments at both 6 and 12 months after surgery. There were no adverse events during the trial. CONCLUSION: LET in combination with ACLR may affect the cartilage contact center during downhill running in the early post-operation phase, but this effect is lost in the longer term. This suggests that healing and neuromuscular adaptation occur over time and may also indicate a dampening of the effect of LET over time. (337 /350 words) LEVEL OF EVIDENCE: Level II.

Symmetry and sex differences in knee kinematics and ACL elongation in healthy collegiate athletes during high-impact activities revealed through dynamic biplane radiography.

The objectives of this study were to determine symmetry and sex differences in knee kinematics and anterior cruciate ligament (ACL) elongation waveforms in healthy athletes without a history of a knee injury during fast running, drop jump, and 180° internal/external rotation hops. It was hypothesized that knee abduction angle and ACL relative elongation would be greater in women than in men during all activities. Bilateral knee kinematics and ACL relative elongation were determined in 19 collegiate athletes using dynamic biplane radiography. Sex differences in kinematics and ACL relative elongation waveforms were identified using statistical parametric mapping. Average absolute side-to-side differences (SSDA ) in kinematics and ACL relative elongation waveforms were determined for each activity. Women had up to 2.3° (all p < 0.05) less knee adduction angle and had greater ACL relative elongation (max. 4.8%-9.2%; all p < 0.01) than men during all activities, in support of the hypotheses. SSDA in kinematics were 1.4 mm and 5.5° or less in all components of translation and rotation, respectively, while SSDA in ACL relative elongation was 3.6% or less across all activities. Greater ACL relative elongation across a variety of activities may make women more susceptible to ACL injury than men. This study provides valuable reference data for identifying abnormal asymmetry in knee kinematics and ACL elongation in athletes after the ACL injury. These novel results improve our understanding of ACL elongation during demanding athletic activities and may help guide the development of sex-specific risk screening metrics, return to play assessments, and rehabilitation protocols after the ACL injury.

Residual limb shear strain during gait is correlated with patient reported outcomes for persons with transfemoral amputation.

The purpose of this study was to measure residual limb skin strain and strain rate within the socket during gait in individuals with a transfemoral amputation and to determine if skin strain during gait is related to patient-reported comfort and function. It was hypothesized that greater skin strain and skin strain rate would correlate to worse patient-reported outcomes. It was also hypothesized that skin strain would progressively increase from the distal to the proximal end of the residuum and maximum strain would occur shortly after heel strike. Dynamic biplane radiography (DBR), combined with conventional motion capture, was used to measure skin deformation within the socket during treadmill walking for 10 persons with unilateral transfemoral amputation. The questionnaire for persons with a transfemoral amputation (Q-TFA) was administered to assess prosthetic use, mobility, health problems, and global health. Q-TFA Prosthetic Use score and Problem score were negatively correlated with the peak shear strains in the proximal and distal regions of the residuum, respectively. Maximum shear strain increased progressively from proximal to distal regions of the residual limb. Within-subject variability in shear strain waveforms during gait was 0.7% or less, but between-subject variability was 3.3% to 5.0% shear. This study demonstrates that skin shear within the socket of persons with transfemoral amputation can be measured during gait using DBR and the results suggest that greater skin shear in the proximal region of the socket is related to decreased prosthetic use.

Syndesmosis Repair Affects in Vivo Distal Interosseous Tibiofibular Ligament Elongation Under Static Loads and During Dynamic Activities.

BACKGROUND: Ligamentous ankle injuries are the most common injuries sustained by athletes and by the general population, with an incidence of approximately 2 million per year in the U.S. Injuries to the ankle syndesmosis (i.e., "high ankle sprains") are generally treated operatively. Although cadaveric studies can evaluate syndesmosis fixation strength, they cannot predict how healing, neuromuscular adaptation, or dynamic loading will affect in vivo biomechanics. Using dynamic biplane radiography (DBR), we tested the hypothesis that syndesmosis repair would restore ankle kinematics and ligament elongation during static and dynamic loading. METHODS: A convenience sample of 6 male patients who had undergone fixation (2 screw, 3 suspensory, 1 hybrid) of syndesmosis injury were assessed with use of DBR during forward running, backpedaling, a 45° angled single-leg hop, and 1 static standing trial at 2 to 4.5 years postoperatively. Three-dimensional ankle kinematics and elongation of the distal interosseous ligament, anterior inferior tibiofibular ligament, and the posterior inferior tibiofibular ligament were measured bilaterally. Comparisons were made between the operative and uninjured sides. Clinical outcomes were evaluated with use of the Foot and Ankle Ability Measure. RESULTS: Static load increased the lengths of the distal interosseous ligament (p = 0.02 to 0.05) and middle segment of the anterior inferior tibiofibular ligament (p = 0.02) in the operative ankle. The distal syndesmosis length was greater on the operative side during the static unloaded and loaded conditions (p = 0.02). Length of the distal syndesmosis on the operative side was greater than the corresponding healthy syndesmosis length during all 3 dynamic activities. On average, the operative ankle was in less dorsiflexion over the support phase of the angled hop (p = 0.05) and running (p < 0.01). The average Foot and Ankle Ability Measure Activities of Daily Living and Sports subscale scores were 95 and 88, respectively. CONCLUSIONS: This study provides the first in vivo evidence of post-fixation changes in biomechanics after syndesmosis repair. Syndesmosis repair fails to restore healthy static and dynamic distal tibiofibular anatomy, even in patients who report good to excellent clinical outcomes. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Lateral Extra-articular Tenodesis Contributes Little to Change In Vivo Kinematics After Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial.

BACKGROUND: Lateral extra-articular tenodesis (LET) in combination with anterior cruciate ligament (ACL) reconstruction (ACLR) has been proposed to improve residual rotatory knee instability in patients having ACL deficiency. PURPOSE/HYPOTHESIS: The purpose was to compare the effects of isolated ACLR (iACLR) versus LET in combination with ACLR (ACLR+LET) on in vivo kinematics during downhill running. It was hypothesized that ACLR+LET would reduce the internal rotation of the reconstructed knee in comparison with iACLR. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 18 patients with ACL deficiency were included. All participants were randomly assigned to receive ACLR+ LET or iACLR during surgery. Six months and 12 months after surgery, knee joint motion during downhill running was measured using dynamic biplane radiography and a validated registration process that matched patient-specific 3-dimensional bone models to synchronized biplane radiographs. Anterior tibial translation (ATT; positive value means "anterior translation") and tibial rotation (TR) relative to the femur were calculated for both knees. The side-to-side differences (SSDs) in kinematics were also calculated (operated knee-contralateral healthy knee). The SSD value was compared between ACLR+LET and iACLR groups using a Mann-Whitney U test. RESULTS: At 6 months after surgery, the SSD of ATT in patients who had undergone ACLR+LET (-1.9 ± 2.0 mm) was significantly greater than that in patients who had undergone iACLR (0.9 ± 2.3 mm) at 0% of the gait cycle (foot strike) (P = .031). There was no difference in ATT 12 months after surgery. Regarding TR, there were no differences between ACLR+LET and iACLR at either 6 months (P value range, .161-.605) or 12 months (P value range, .083-.279) after surgery. CONCLUSION: LET in combination with ACLR significantly reduced ATT at the instant of foot strike during downhill running at 6 months after surgery. However, this effect was not significant at 12 months after surgery. The addition of LET to ACLR had no effect on TR at both 6 and 12 months after surgery. CLINICAL RELEVANCE: LET in combination with ACLR may stabilize sagittal knee motion during downhill running in the early postoperation phase, but according to this study, it has no effect on 12-month in vivo kinematics. REGISTRATION: NCT02913404 (ClinicalTrials.gov identifier).

Optimising the delivery of remediation programmes for doctors: A realist review.

CONTEXT: Medical underperformance puts patient safety at risk. Remediation, the process that seeks to 'remedy' underperformance and return a doctor to safe practice, is therefore a crucially important area of medical education. However, although remediation is used in health care systems globally, there is limited evidence for the particular models or strategies employed. The purpose of this study was to conduct a realist review to ascertain why, how, in what contexts, for whom and to what extent remediation programmes for practising doctors work to restore patient safety. METHOD: We conducted a realist literature review consistent with RAMESES standards. We developed a programme theory of remediation by carrying out a systematic search of the literature and through regular engagement with a stakeholder group. We searched bibliographic databases (MEDLINE, EMBASE, PsycINFO, HMIC, CINAHL, ERIC, ASSIA and DARE) and conducted purposive supplementary searches. Relevant sections of text relating to the programme theory were extracted and synthesised using a realist logic of analysis to identify context-mechanism-outcome configurations (CMOcs). RESULTS: A 141 records were included. The majority of the studies were from North America (64%). 29 CMOcs were identified. Remediation programmes are effective when a doctor's insight and motivation are developed and behaviour change reinforced. Insight can be developed by providing safe spaces, using advocacy to promote trust and framing feedback sensitively. Motivation can be enhanced by involving the doctor in remediation planning, correcting causal attribution, goal setting and destigmatising remediation. Sustained change can be achieved by practising new behaviours and skills, and through guided reflection. CONCLUSION: Remediation can work when it creates environments that trigger behaviour change mechanisms. Our evidence synthesis provides detailed recommendations on tailoring implementation and design strategies to improve remediation interventions for doctors.

Tibiofemoral helical axis of motion during the full gait cycle measured using biplane radiography.

The helical axis of motion (HAM), which describes the simultaneous multiplanar translations and rotations that occur within a joint, has been proposed as a single measure to characterize dynamic joint function. The objective of this study was to determine the tibiofemoral HAM during 5 discrete phases of gait. Thirty-nine knees from 20 healthy adults were imaged using high-speed biplane radiography during treadmill walking. The primary outcome measures were the intersection of the HAM with the sagittal plane of the femur, and the direction of the HAM. The intersection point translated an average of 12.7 ± 5.5% of femur condyle depth in the anterior-posterior direction and 28.6 ± 13.3% of femur condyle height in the proximal-distal direction during gait. The anterior/posterior and proximal/distal components of the HAM vector were greater during stance (5.6°±3.8° and 11.1°±5.0°, respectively) than during swing (2.0°±1.1° and 6.4°±3.8°, respectively) (p<0.001) reflecting greater coupled rotations during stance. No significant side-to-side differences in intersection point location or HAM orientation were found during any of the 5 phases of gait (max difference 4.1 ± 3.4% of femur condyle depth and 13.1 ± 16.7% of femur condyle height; 12.7°±12.3° proximal/distal and 4.2°±4.5° anterior/posterior direction). Loading significantly affected HAM location and orientation (p<0.001). Knowledge of healthy knee HAM and typical side-to-side differences during gait can serve as a baseline for evaluating knee motion after clinical interventions.

Motion of the residual femur within the socket during gait is associated with patient-reported problems in transfemoral amputees.

The purpose of this study was to provide a quantitative description of residual femur motion within the socket during gait and to explore the relationship between residual femur motion and patient-reported comfort and function. It was hypothesized that increased residual bone movement would correlate to worse patient-reported comfort and function. The secondary goals were to assess within-subject step-to-step variability and between-subject variability in residual femur motion within the socket during gait. Dynamic biplane radiography, combined with conventional motion capture, was used to measure residual femur motion within the socket during treadmill walking for 10 unilateral transfemoral amputees. The questionnaire for persons with a transfemoral amputation (Q-TFA) was administered to assess prosthetic use, mobility, health problems, and global health. Increased femur pistoning (proximal-distal translation relative to the socket) correlated with worsening Q-TFA problem and global scores (ρ = 0.741, p = 0.04 and ρ = -0.783, p = 0.02, respectively). Average residual femur rotation ROMs were 7.3°±3.7°, 10.8°±4.4°, and 7.7°±4.8° for anterior tilt, internal-external rotation, and varus-valgus, respectively. Average residual femur translation ROMs were 8.6 mm ± 3.0 mm, 28.4 mm ± 13.9 mm, and 20.4 mm ± 7.2 mm for medial-lateral, pistoning, and anterior-posterior directions, respectively. Within-subject rotational and translational variability during gait averaged 2.8° and 2.0 mm or less, whereas the between-subject variability was up to 9.4° and 18.6 mm, which demonstrates residual femur motion relative to the socket is repeatable within subjects, but inconsistent across subjects during gait. The results suggest residual bone motion within the socket is a potential mechanism behind patient-reported problems and suggests a target for intervention aimed at improving transfemoral amputee quality of life.

An automated method for defining anatomic coordinate systems in the hindfoot.

The absence of a standardized method for defining hindfoot bone coordinate systems makes it difficult to compare kinematics results from different research studies. The purpose of this study was to develop a reliable and robust procedure for defining anatomical coordinate systems for the talus and calcaneus. Four methods were evaluated based upon their anatomic consistency across subjects, repeatability, and their correspondence to functional axes of rotation. The four systems consisted of: 1) interactively identified bony landmarks, 2) a principal component analysis, 3) automatically identified bony landmarks, and 4) translating the tibial coordinate system to the hindfoot bones. The four systems were evaluated on 40 tali and 40 calcanei. The functional axes of rotation were determined using dynamic biplane radiography to image the hindfoot during gait. Systems 2 and 3 were the most repeatable and consistent due to the lack of operator intervention when defining coordinate systems. None of the coordinate systems corresponded well to functional axes of rotation during gait. System 3 is recommended over System 2 because it more closely mimics established bone angles measured clinically, especially for the calcaneus. This study presents an automated method for defining anatomic coordinate systems in the talus and calcaneus that does not rely on manual placement of markers or fitting of spheres to the bone surfaces which are less reliable due to operator-dependent measurements. Using this automated method will make it easier to compare hindfoot kinematics results across research studies.