RESUMEN
BACKGROUND: Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features. MATERIAL AND METHODS: We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry. RESULTS: A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001). CONCLUSION: This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group.
Asunto(s)
Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo , Neoplasias Orofaríngeas/metabolismo , Orofaringe/metabolismo , Carcinoma de Células Escamosas de Cabeza y Cuello/metabolismo , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Consumo de Bebidas Alcohólicas , Estudios Transversales , Femenino , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Neoplasias Orofaríngeas/epidemiología , Neoplasias Orofaríngeas/patología , Orofaringe/patología , Factores de Riesgo , Factores Sexuales , Conducta Sexual , Fumar , Carcinoma de Células Escamosas de Cabeza y Cuello/epidemiología , Carcinoma de Células Escamosas de Cabeza y Cuello/patología , Adulto JovenRESUMEN
BACKGROUND: Counting the sponges is an important step in surgical procedures. A miscount may impact the patient's health, and it also has legal implications for the surgeon. This is an experimental study evaluating radio-frequency technology used in the perioperative period to identify surgical sponges left in the peritoneal cavity of swine. METHODS: Radio-frequency labeled-disc identification tags were sewn into 40 surgical towels. Twenty labels had the ability to emit radio-frequency waves, and 20 labels were inert to radio-frequency identification. Twenty adult pigs that underwent laparotomy and randomly received two surgical sponges were scanned by a radio-frequency identification antenna. RESULTS: This method presented a positive predictive value of 100% and 100% specificity and sensitivity, as all of the tagged surgical sponges were detected. CONCLUSION: Radio-frequency identification has been proved to be a useful method for the identification of surgical sponges within the abdominal cavities of swine.