[Use of thrombin generation assay for the evaluation of coagulation and anticoagulant activity of hemostasis system in patients with abdominal sepsis].

Generally recognized factor, which complicates the course of sepsis, is the development of hypercoagulation syndrome. The increase of thrombin coagulation indicates on the elevation of risk of thrombus formation in microcirculation vessels, which could cause the formation of multiple organ failure. The thrombin generation assay is a new method of the evaluation of homeostasis system status. The test reflects the fermentation activity of thrombin and shows the functional condition, which arises in the interaction of procoagulant and anticoagulant. The diagnosis of generalized peritonitis had 30 patients (18 men and 12 women, aged 61+/-18,3 years) and they were included in the research. It was shown, that the use of thrombin generation assay in patients with the abdominal sepsis could give the well-timed analysis of hypercoagulation changes and the assessment of protein C system investment in the thrombin generation.

[Assessment of endogenous thrombin potential and influence on it of different regimens of heparin therapy in patients with abdominal sepsis].

Abdominal sepsis (AS) is a systemic inflammatory reaction of organism in response to the development of infectious process in organs of the abdominal cavity. The course of AS is complicated by hypercoagulation syndrome which facilitates progression of endogenous intoxication. The investigation included 26 patients (14 men and 12 women, mean age 65.5 +/- 16.4 years) with AS. The test of thrombin generation (TTG) used in patients with AS allows assessment of changes in the hemostasis system and control of the heparin dose. It was established that TTG revealed elevated endogenous thrombin potential of blood practically in all patients with AS. In the patients given 25 000 IU of heparin the TTG indices showed a reliably decreased endogenous thrombin potential and peak thrombin concentration as compared with a group of patients given 10 000 IU of heparin.

[A comparative assessment of the methods of prediction of outcomes of acute peritonitis].

An analysis of results of treatment of 212 patients with peritonitis of different etiology allowed the author to establish main factors (clinical and laboratory), responsible for the level of lethality. A scheme of assessment of the outcome of the disease is proposed. It has advantages over the Mannheim Peritonitis Index.

[Disorders of the immune status and hematopoiesis in suppurative peritonitis and their correction with the preparation "Antilympholin"]. / Narusheniia immunnogo statusa i gemotsitopoeza pri gnoinom peritonite i ikh korrektsiia preparatom "Antilimfolin".

In patients with purulent peritonitis, the severe immunodepression and suppression of proliferative activity of stem elements of hemopoietic tissue stroma were revealed. The effectiveness of the use as an immunomodulator of the preparation "Antilympholin" which has the marked immunostimulating properties is shown.