Impact of in-hospital statin use on mortality in COVID-19 patients from a majority African American population.

BACKGROUND: The COVID-19 pandemic has claimed over 6.4 million lives globally. Finding effective medications to reduce mortality in hospitalized COVID-19 patients remains critical. No previous study has been published on the effects of statin use in a majority African American COVID-19 patient population. OBJECTIVE: This study aims to assess the relationship between in-hospital statin use and mortality in this population. METHODS: A retrospective chart review of patients diagnosed with COVID-19 from March 2020 to June 2020 admitted to the Phoebe Putney Health System in Albany, Georgia, an early epicenter of the COVID-19 pandemic, was conducted. The outcomes of 735 hospitalized COVID-19 positive patients from over 40 counties in Georgia were analyzed. The primary outcome of interest was all-cause mortality, with secondary outcomes of interest of ICU care, length of ICU stay, need for mechanical ventilator, duration of intubation, and need for dialysis. Multivariate logistic regression and Cox proportional hazards analysis were conducted to examine the effect of in-hospital statin use and mortality. RESULTS: 186 of 735 total patients were prescribed statins in-hospital. 83.8% were African American. Multivariate logistic regression found in-hospital statin use was not significantly associated with the primary outcome - all-cause mortality (p=0.23). Similar findings were seen in need for ICU care, length of ICU stay, need for mechanical ventilator, duration of intubation, and need for dialysis (p>0.05). Additionally, results from a Cox proportional hazards model found in-hospital statin use was not associated with survival time. Sensitivity analysis conducted on only African American patients validated that in-hospital statin use was not associated with all-cause mortality in these patients. Of note, immunosuppression and severe disease presentation were associated with a six-fold increase in risk of mortality and the largest decreases in survival time. CONCLUSION: It is possible statins have no mortality benefit for this patient population, but further research beyond this association study would need to be conducted to determine this conclusively. From this study, the best clinical recommendation would be to continue statins for COVID-19 patients with pre-hospital statin use and to launch a randomized clinical trial to definitively determine the efficacy of statins in the treatment of hospitalized COVID-19 patients.

Anti-CD64 Antibody-Conjugated PLGA Nanoparticles Containing Methotrexate and Gold for Theranostics Application in Rheumatoid Arthritis.

Rheumatoid arthritis, an autoimmune disorder, exerts a considerable effect on quality of life. The inflammatory mechanism involved in rheumatoid arthritis is not clearly known, and therefore the need to develop effective medicines as well as new methods for early detection is a challenge. In this study, we developed PLGA nanoparticles containing gold and methotrexate in core and anti-CD64 antibody conjugated to nanoparticle surface via coupling process. The nanoparticles were examined for their surface morphology using SEM and TEM. The mean particle size, zeta potential, and PDI values of nanoparticles were 413.6 ± 2.89 nm, -10.12 ± 2.12 mV, and 0.23 ± 0.04, respectively, indicating good stability and particle homogeneity. In vitro drug release revealed a controlled release pattern with 93.44 ± 1.60% up to 72 h of release in the presence of pH 5.8, indicating the influence of pH and NIR on drug release. In vivo results on adjuvant-induced arthritis on Wistar rats indicated that animals receiving antibody-conjugated nanoparticles showed improvement in clinical indices and arthritic score as compared to non-conjugated nanoparticles and free drugs. This innovative drug delivery system will be an excellent strategy to maximize therapeutic effectiveness by limiting dosage-related side effects.

Cyclodextrins-modified metallic nanoparticles for effective cancer therapy.

Cancer, a disease of unknown origin is the second most common reason of death worldwide after heart attacks and therefore is a major threat to human beings. Currently, chemotherapy is the only approach for delivering anti-cancer drugs but shows severe systemic toxicities such as alopecia, loss of appetite, anemia, gastric irritation, neurotoxicity and nephrotoxicity. Additionally, chemotherapeutics fails to achieve the expected therapeutic outcome due to their limited solubility, in-vivo instability and lack of targeting efficiency. Encapsulating drugs in metallic nanoparticles like gold, silver and metal oxides (magnetic) help to overcome limitations of chemotherapy and transports anti-cancer drugs effectively at the targeted site due to the advantages such as optimal size, surface morphology, higher conductivity and in-vivo stability. Moreover, these metals can be triggered externally using NIR radiations or magnetic field thereby improving the drug release kinetics. Some frequently used chemotherapeutic agents such as doxorubicin, paclitaxel, methotrexate, etc. degrade rapidly due to their hydrophobic nature and show in-vivo instability. Cyclodextrin offers structural compatibility for encapsulating such hydrophobic drugs and improves their loading capacity, solubility and stability without showing any systemic toxicities. Therefore, researchers designed cyclodextrin-complexed metallic nanoparticles as a novel platform to overcome pitfalls of conventional chemotherapy like gastric irritation, hair loss, neurotoxicity, etc. This review article provides detail insight of metallic nanocarriers containing cyclodextrin-encapsulated anti-cancer agents for effective cancer therapy. It can be concluded that this novel approach holds a great potential for clinical application in cancer diagnosis, treatment with minimum toxicity and maximum efficacy.

A key role by polymers in microneedle technology: a new era.

The skin serves as the major organ in the targeted transdermal drug delivery system for many compounds. The microneedle acts as a novel technique to deliver drugs across the different layers of the skin, including the major barrier stratum corneum, in an effective manner. A microneedle array patch comprises dozens to hundreds of micron-sized needles with numerous structures and advantages resulting from their special and smart designs. The microneedle approach is much more advanced than conventional transdermal delivery pathways due to several benefits like minimally invasive, painless, self-administrable, and enhanced patient compliance. The microneedles are classified into hollow, solid, coated, dissolving, and hydrogel. Several polymers are used to fabricate microneedle, such as natural, semi-synthetic, synthetic, biodegradable, and swellable polymers. Researchers in the preparation of microneedles also explored the combinations of polymers. The safety of the polymer used in microneedle is a crucial aspect to prevent toxicity in vivo. Thus, this review aims to provide a detailed review of microneedles and mainly focus on the various polymers used in the fabrication of microneedles.

Unraveling the Mystery of the Blue Fog: Structure, Properties, and Applications of Amorphous Blue Phase III.

The amorphous blue phase III of cholesteric liquid crystals, also known as the "blue fog," are among the rising stars in materials science that can potentially be used to develop next-generation displays with the ability to compete toe-to-toe with disruptive technologies like organic light-emitting diodes. The structure and properties of the practically unobservable blue phase III have eluded scientists for more than a century since it was discovered. This progress report reviews the developments in this field from both fundamental and applied research perspectives. The first part of this progress report gives an overview of the 130-years-long scientific tour-de-force that very recently resulted in the revelation of the mysterious structure of blue phase III. The second part reviews progress made in the past decade in developing electrooptical, optical, and photonic devices based on blue phase III. The strong and weak aspects of the development of these devices are underlined and criticized, respectively. The third- and-final part proposes ideas for further improvement in blue phase III technology to make it feasible for commercialization and widespread use.

Electro-optical Memory of a Nanoengineered Amorphous Blue-Phase-III Polymer Scaffold.

An electro-optical (EO) memory device is presented, which is based on a 3D nanostructured polymer scaffold of the amorphous blue phase III (BPIII) of cholesteric liquid crystals (LCs), which can impart optical isotropy, optical activity, and sub-millisecond EO response of BPIII to conventional nematic LCs. This functional scaffold also enables the first experimental observation of the long debated structure of BPIII.

Thermoresponsive Gelatin Nanogels.

We present a novel tunable thermoresponsive gelatin nanogel that shows a volume transition at ∼32 °C. A thermally induced volume reduction of more than 30× is observed due to the helix to random coil transition of gelatin chains confined in the nanogels. The physical process and key factors influencing thermoresponsive properties are investigated using dynamic light scattering (DLS), transmission electron microscopy (TEM), and polarimetry. The thermoresponsive properties of this nanogel can be exploited in the development of new types of stimuli-responsive, biomedically relevant materials based on natural polymers.