RESUMEN
A 9-month-old infant with left ovarian Sertoli Leydig cell tumors (SLCTs) was reported and the special histological pattern was that the main components of the tumor were leydig cells. She was the youngest reported case of the tumor. The patient had increased serum estradiol and A-Fetoprofein (AFP) and a left oophorectomy was performed. After surgery, the patient has not received any treatment. So far, the patient has been well and survived without recurrence for 40 months.
Asunto(s)
Neoplasias Ováricas/patología , Tumor de Células de Sertoli-Leydig/patología , Biomarcadores de Tumor/metabolismo , Estradiol/sangre , Femenino , Humanos , Inmunohistoquímica/métodos , Lactante , Neoplasias Ováricas/sangre , Neoplasias Ováricas/cirugía , Ovariectomía , Tumor de Células de Sertoli-Leydig/sangre , Tumor de Células de Sertoli-Leydig/cirugía , Resultado del Tratamiento , alfa-Fetoproteínas/metabolismoRESUMEN
OBJECTIVE: To study the clinicopathologic features and biological behavior of spermatocytic seminoma. METHODS: A retrospective analysis of patients diagnosed as seminoma, spermatocytic seminoma between January 2003 and May 2011, was performed. Clinical data, HE stained section and immunohistochemical staining (SP method) were reviewed with follow-up. RESULTS: Sixty-six cases of seminoma and 5 cases of spermatocytic seminoma were identified. The average age at the diagnosis of 5 cases of spermatocytic seminoma was 53 years, and no patient had a history of crytorchidism or germ cell tumor. All five patients had stage pT1 tumor. Immunohistochemical studies showed that spermatocytic seminoma was negative for CK, vimentin, OCT3/4, PLAP, and LCA, and PAS staining was also negative. All five patients were well after operation. In contrast, the average age at diagnosis of the 66 cases of seminoma was 37 years, in which 12% had a history of crytorchidism and 11% were in stage pT2 or the above. Immunohistochemical studies showed that seminoma was positive for OCT3/4, PLAP, and CD117. During the follow-up, 2 patients developed metastasis and 3 patients died of the disease. CONCLUSIONS: Spermatocytic seminoma is rare and appears to follow a benign clinical course Due to its favourable prognosis, further treatment is not necessary after orchidectomy. Accurate pathologic diagnosis is critical for patient management and for avoiding over-treatment.
Asunto(s)
Seminoma/patología , Espermatocitos/patología , Neoplasias Testiculares/patología , Adulto , Anciano , Fosfatasa Alcalina/metabolismo , Diagnóstico Diferencial , Estudios de Seguimiento , Proteínas Ligadas a GPI/metabolismo , Humanos , Isoenzimas/metabolismo , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Factor 3 de Transcripción de Unión a Octámeros/metabolismo , Orquiectomía , Proteínas Proto-Oncogénicas c-kit/metabolismo , Estudios Retrospectivos , Seminoma/metabolismo , Seminoma/cirugía , Neoplasias Testiculares/metabolismo , Neoplasias Testiculares/cirugíaRESUMEN
The primary extrapulmonary sugar tumor (PEST) is rare. Up to now, only 16 cases of PEST have been reported, including 5 pediatric cases. We report a renal benign PEST in a 16-year-old boy, which is the first such case to be reported in the pediatric kidney. The tumor was composed of clear and eosinophilic epithelioid cells, growing with nest and pseudoalveolar structure, which can be confused with renal clear cell carcinoma. The tumor cells were positive for melanocytic and negative for epithelial markers. The tumor was enucleated, and the patient was well without recurrence 21 months after surgery.
