RESUMEN
Random fluctuations are inescapable feature in biological systems, but appropriate intensity of randomness can effectively facilitate information transfer and memory encoding within the nervous system. In the study, a modified spiking neuron-astrocyte network model with excitatory-inhibitory balance and synaptic plasticity is established. This model considers external input noise, and allows investigating the effects of intrinsic random fluctuations on working memory tasks. It is found that the astrocyte network, acting as a low-pass filter, reduces the noise component of the total input currents and improves the recovered images. The memory performance is enhanced by selecting appropriate intensity of random fluctuations, while excessive intensity can inhibit signal transmission of network. As the intensity of random fluctuations gradually increases, there exists a maximum value of the working memory performance. The cued recall of the network markedly decreases excessive input noise relative to test images. Meanwhile, a greater contrast effect is observed as the external input noise increases. In addition, synaptic plasticity reduces the firing rates and firing peaks of neurons, thus stabilizing the working memory activity during the test. The outcomes of this study may provide some inspirations for comprehending the role of random fluctuations in working memory mechanisms and neural information processing within the cerebral cortex.
RESUMEN
Previous studies have shown that astrocytes are involved in information processing and working memory (WM) in the central nervous system. Here, the neuron-astrocyte network model with biological properties is built to study the effects of excitatory-inhibitory balance and neural network structures on WM tasks. It is found that the performance metrics of WM tasks under the scale-free network are higher than other network structures, and the WM task can be successfully completed when the proportion of excitatory neurons in the network exceeds 30%. There exists an optimal region for the proportion of excitatory neurons and synaptic weight that the memory performance metrics of the WM tasks are higher. The multi-item WM task shows that the spatial calcium patterns for different items overlap significantly in the astrocyte network, which is consistent with the formation of cognitive memory in the brain. Moreover, complex image tasks show that cued recall can significantly reduce systematic noise and maintain the stability of the WM tasks. The results may contribute to understand the mechanisms of WM formation and provide some inspirations into the dynamic storage and recall of memory.
