Signo de "sal y pimienta" como presentación de una lesión pontina no vascular / "Salt and pepper" sign in the onset of a non-vascular pontine pathology

No disponible

Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety.

Canine atopic dermatitis (AD) is a common skin disease with a 10-15 per cent prevalence. Current treatments vary in their efficacy and safety. The immunomodulatory properties of mesenchymal stem cells (MSCs) make them a promising alternative treatment. The aim of this study was to evaluate the therapeutic efficacy and safety of allogeneic canine adipose MSCs (cAd-MSCs) in dogs with refractory AD. Twenty-six dogs, suffering from AD for at least 12 months, not responding to conventional therapy, received an intravenous dose of 1.5×106 cAd-MSCs/kg bodyweight. Clinical signs, haematological and biochemistry profiles, and AD severity were assessed in a six-month follow-up using a validated scoring system (Canine Atopic Dermatitis Extent and Severity Index, version 4 (CADESI-04)). The degree of pruritus was quantified using a validated visual analogue scale, and also owner's global assessment of treatment efficacy. Twenty-two animals completed the study. Pruritus and CADESI-04 scores decreased significantly after one week or month of treatment, respectively, and remained stable for six months. Owner's global assessment score was 2.15±1.15 for all the animals in the study. In conclusion, systemic administration of allogeneic cAd-MSCs appeared to be a simple therapy with positive outcome in the remission of clinical signs for AD refractory to conventional medications, for at least six months and with no adverse events.

Eficacia de canulación biliar y riesgo de pancreatitis de dos técnicas de precorte empleadas de forma precoz / Biliary cannulation effectiveness and pancreatitis risk using two early precut techniques

Introducción: las técnicas de precorte permiten alcanzar tasas de canulación biliar próximas al 100% aunque pueden elevar el riesgo de complicaciones. Recientemente, el precorte de aguja precoz se ha demostrado seguro y se propone como recurso preventivo de pancreatitis en casos de canulación difícil. El objetivo del presente estudio es evaluar las tasas de canulación y pancreatitis de dos técnicas de precorte ejecutadas precozmente. Pacientes y método: estudio retrospectivo de las colangio- pancreatografías retrógradas endoscópicas (CPRE) realizadas entre 2013 y 2016. Se analiza la eficacia y seguridad de la canulación simple, del precorte de aguja y del precorte transpancreático. Resultados: de 503 CPRE analizables se obtuvo la canulación simple en 369 (73,4%). En 53 casos se realizó un precorte de aguja, con éxito en 51 (96,2%), y en 78 casos se realizó un precorte transpancreático, con éxito en 75 (96,2%). La tasa global de canulación fue del 98,4%. En total se registraron once pancreatitis (2,4%), seis (1,8%) en las canulaciones simples (dos graves y una fatal), cinco (6,3%) en los precortes transpancreáticos (dos graves) y cero en los precortes de aguja. En los pacientes sometidos a precorte se registraron siete perforaciones (dos graves) y siete hemorragias, siendo la tasa global de complicaciones del 14,4%. Conclusiones: el empleo complementario de ambas técnicas de precorte permite alcanzar una tasa de canulación biliar satisfactoria. No obstante, la tasa de pancreatitis y otras complicaciones graves del precorte transpancreático es superior a la del precorte de aguja, lo que aconseja modificar la indicación de cada técnica (AU)

Introduction: Precut techniques allow for successful biliary cannulation rates approaching 100% but there may be an associated increase in the risk of complications. Recently, early needle-knife precut has been shown to be a safe procedure and is now used as a pancreatitis prevention resource for difficult cannulation cases. The goal of the present study was to assess cannulation and pancreatitis rates using two early precut techniques. Patients and methods: This was a retrospective study of endoscopic retrograde cholangio-pancreatography (ERCP) procedures performed from 2013 to 2016. The efficacy and safety of simple cannulation, needle-knife precut and transpancreatic precut were assessed. Results: Simple cannulation was achieved in 369 (73.4%) of 503 evaluable ERCP procedures. Needle-knife precut was successful in 51 (96.2%) of 53 attempts and transpancreatic precut was successful in 75 (96.2%) of 78 attempts. The overall cannulation rate was 98.4%. There were eleven (2.4%) pancreatitis events, six (1.8%) with simple cannulation (two severe, one fatal), five (6.3%) with transpancreatic precut (two severe) and zero events with the needle-knife precut procedure. Among the patients undergoing the precut procedure, seven experienced perforations (two severe) and there were seven bleeding events. The overall complication rate was 14.4%. Conclusions: The complementary use of either precut technique provides a satisfactory biliary cannulation rate. However, the rates of pancreatitis and other severe complications are higher for transpancreatic versus needle-knife precut, therefore the indications for both techniques should be modified (AU)

Alkali-metal-ion-directed self-assembly of redox-active manganese(III) supramolecular boxes.

The ability to organize functional molecules into higher dimensional arrays with well-defined spatial relationships between the components is one of the major goals in supramolecular chemistry. We report here a new route for the preparation of supramolecular boxes, incorporating two types of metal ions: (i) alkali-metal ions, which induce the supramolecular architecture and essentially play a structural role in the final compounds; (ii) manganese(III) ions, which are redox-active systems and give functionality to the new cages. Our results evidence that the size of the cavity inside the box can be tuned depending on the alkali metal used, a characteristic that gives this new family of compounds the potential to act selectively against different substrates. These compounds behave as active catalysts for disproportionation of H2O2 or for water photolysis, but they catalyze neither catecholase reaction nor peroxidase action upon using bulky organic substrates.

Measurement invariance study of the training satisfaction questionnaire (TSQ).

This article presents an empirical measurement invariance study in the substantive area of satisfaction evaluation in training programs. Specifically, it (I) provides an empirical solution to the lack of explicit measurement models of satisfaction scales, offering a way of analyzing and operationalizing the substantive theoretical dimensions; (II) outlines and discusses the analytical consequences of considering the effects of categorizing supposedly continuous variables, which are not usually taken into account; (III) presents empirical results from a measurement invariance study based on 5,272 participants' responses to a training satisfaction questionnaire in three different organizations and in two different training methods, taking into account the factor structure of the measured construct and the ordinal nature of the recorded data; and (IV) describes the substantive implications in the area of training satisfaction evaluation, such as the usefulness of the training satisfaction questionnaire to measure satisfaction in different organizations and different training methods. It also discusses further research based on these findings.

Measurement invariance study of the training satisfaction questionnaire (TSQ)

This article presents an empirical measurement invariance study in the substantive area of satisfaction evaluation in training programs. Specifically, it (I) provides an empirical solution to the lack of explicit measurement models of satisfaction scales, offering a way of analyzing and operationalizing the substantive theoretical dimensions; (II) outlines and discusses the analytical consequences of considering the effects of categorizing supposedly continuous variables, which are not usually taken into account; (III) presents empirical results from a measurement invariance study based on 5,272 participants’ responses to a training satisfaction questionnaire in three different organizations and in two different training methods, taking into account the factor structure of the measured construct and the ordinal nature of the recorded data; and (IV) describes the substantive implications in the area of training satisfaction evaluation, such as the usefulness of the training satisfaction questionnaire to measure satisfaction in different organizations and different training methods. It also discusses further research based on these findings (AU)

No disponible

Versatile coordination behaviour of an asymmetric half-salen ligand bearing a dansyl fluorophore.

The coordinative chemistry of the tridentate half-salen ligand 5-(dimethylamino)-N-(2-((2-hydroxybenzylidene)amino)phenyl)naphthalene-1-sulfonamide (H(2)L, 1) has been studied by means of an electrochemical method. All of the complexes have been characterised using analytical and spectroscopic techniques. Ligand 1 and two nickel (6 and 7), copper (9), zinc (12) and cadmium (14) metal complexes have been studied by crystallography. Complexes 6 and 7 are octahedral and tetrahedral nickel(II) complexes, respectively, and both contain an [L](2-) molecule that behaves in an [N(2)O] tridentate manner. Nickel(II) completes its coordination kernel with three water molecules in complex 6, whereas in complex 7 the nickel ion is further bound to a molecule of dansylamine arising from a hydrolysis process. The copper(II) complex 9 is a monomeric compound that contains a bideprotonated ligand thread and a dimethylsulfoxide molecule coordinated through the sulfur atom. The zinc complex 12 is an unusual pentanuclear cluster compound whose structure consists of four anionic ligand units and two hydroxo anions bound to five zinc(II) centres. The appearance of the hydroxo anions in this complex provides new evidence for water reduction electrochemically promoted by zinc metal under mild conditions. The cadmium complex 14 is a dimeric compound that comprises two molecules of the anionic ligand and two dimethylsulfoxide molecules. The great structural variety exhibited by all these complexes demonstrates that the introduction of asymmetry in a salen skeleton by incorporating a dansyl pendant increases the versatility of the resulting ligand on coordination. All complexes are luminescent in solution at room temperature in acetonitrile solutions.

Incidencia de caídas en un hospital de nivel 1: factores relacionados / Incidence of falls in a University Hospital: factors related

Introducción: las caídas son un riesgo real que acontece en el medio hospitalario, y constituyen un indicador de calidad asistencial. La Organización Mundial de la Salud(OMS) define el término caída como “la consecuencia de cualquier acontecimiento que precipita al individuo hacia el suelo en contra de su voluntad”. Objetivo: analizar la incidencia de caídas, el perfil de los pacientes que sufren caídas en el hospital e identificar las posibles causas y efectos de la misma. Metodología: estudio descriptivo sobre las caídas registradas en el Complejo Hospitalario de Jaén durante la estancia hospitalaria. La obtención de datos se hizo directamente por las supervisoras. Se elaboró una hoja de recogida de datos cuyas anotaciones se transmitieron a una base de datos electrónica. Las variables que se recogieron fueron datos de filiación del paciente, fecha y hora de la caída, unidad donde se produce la caída, puntuación escala Morse, caídas previas, circunstancias de la caída, factores relacionados como medicación, trastornos (..) (AU)

Introduction: falls are a real risk that occurs in hospitals; falls are health a care quality indicator. The World Health Organization (WHO) defines the term falls as the result of any event which precipitate someone to the ground against their will. Aims: to analyze the incidence of falls, the profile of patients who fall in the hospital and to identify causes and effects. Methodology: design: Descriptive study on falls reported in Jaen’s Hospital, which includes any fall(36) that has taken place at some time of hospital stay. Data collection was performed by each unit supervisors developed a data collection sheet. Data were transcribed to a database. Variables collected were: demographic data, date and time of the fall event, unit which produces the fall, Morse scale score, previous falls, fall circumstances, factors such as medication, cognitive, functional factors environment, care after the fall and need for assistive devices. Results: during the period under review there were a total of 36 falls, representing an incidence of (..) (AU)

Influence of the geometry around the manganese ion on the peroxidase and catalase activities of Mn(III)-Schiff base complexes.

The peroxidase and catalase activities of eighteen manganese-Schiff base complexes have been studied. A correlation between the structure of the complexes and their catalytic activity is discussed on the basis of the variety of systems studied. Complexes 1-18 have the general formulae [MnL(n)(D)(2)](X)(H(2)O/CH(3)OH)(m), where L(n)=L(1)-L(13); D=H(2)O, CH(3)OH or Cl; m=0-2.5 and X=NO(3)(-), Cl(-), ClO(4)(-), CH(3)COO(-), C(2)H(5)COO(-) or C(5)H(11)COO(-). The dianionic tetradentate Schiff base ligands H(2)L(n) are the result of the condensation of different substituted (OMe-, OEt-, Br-, Cl-) hydroxybenzaldehyde with diverse diamines (1,2-diaminoethane for H(2)L(1)-H(2)L(2); 1,2-diamino-2-methylethane for H(2)L(3)-H(2)L(4); 1,2-diamino-2,2-dimethylethane for H(2)L(5); 1,2-diphenylenediamine for H(2)L(6)-H(2)L(7); 1,3-diaminopropane for H(2)L(8)-H(2)L(11); 1,3-diamino-2,2-dimethylpropane for H(2)L(12)-H(2)L(13)). The new Mn(III) complexes [MnL(1)(H(2)O)Cl](H(2)O)(2.5) (2), [MnL(2)(H(2)O)(2)](NO(3))(H(2)O) (4), [MnL(6)(H(2)O)(2)][MnL(6)(CH(3)OH)(H(2)O)](NO(3))(2)(CH(3)OH) (8), [MnL(6)(H(2)O)(OAc)](H(2)O) (9) and [MnL(7)(H(2)O)(2)](NO(3))(CH(3)OH)(2) (12) were isolated and characterised by elemental analysis, magnetic susceptibility and conductivity measurements, redox studies, ESI spectrometry and UV, IR, paramagnetic (1)H NMR, and EPR spectroscopies. X-ray crystallographic studies of these complexes and of the ligand H(2)L(6) are also reported. The crystal structures of the rest of the complexes have been previously published and herein we have only revised their study by those techniques still not reported (EPR and (1)H NMR for some of these compounds) and which help to establish their structures in solution. Complexes 1-12 behave as more efficient mimics of peroxidase or catalase in contrast with 13-18. The analysis between the catalytic activity and the structure of the compounds emphasises the significance of the existence of a vacant or a labile position in the coordination sphere of the catalyst.

Manganese-Schiff base complexes as catalysts for water photolysis.

Four manganese(III)-Schiff base complexes (1-4) of formula [MnL(n)(H(2)O)(2)](2)(ClO(4))(2)·mH(2)O (n = 1-4; m = 0, 1) have been prepared. The multidentate H(2)L(n) Schiff base ligands consist of 3R,5R-substituted N,N'-bis(salicylidene)-1,2-diimino-2,2-dimethylethane, where R = OEt, OMe, Br or Cl. The complexes have been thoroughly characterized by elemental analysis, mass spectrometry, magnetic susceptibility measurements, IR, UV, paramagnetic (1)H NMR and EPR spectroscopies. Other properties, including redox studies and molar conductivity measurements, have also been assessed. The crystal structure of 1 was solved by X-ray diffraction, which revealed the dimeric nature of the compound through µ-aqua bridges. The ability of these complexes to split water has been studied by water photolysis experiments, with the oxygen evolution measured in aqueous media in the presence of a hydrogen acceptor (p-benzoquinone), the reduction of which was followed by UV-spectroscopy. The discussion of the photolytic behaviour includes advances in the knowledge of the structural motifs and the chemical activity of this type of complex, as revealed by the development of several characterization techniques in the last decade. Parallel-mode Mn(III) EPR shows that complexes 1-4 not only mimic reactivity but also share some structural characteristics from partially assembled natural OEC clusters.

Epidemiología de la gastroenteritis por rotavirus adquirida en la comunidad en el área de Fuenlabrada (Madrid) / Epidemiology of community-acquired rotavirus gastroenteritis in Fuenlabrada (Madrid)

Introducción: Rotavirus es el agente etiológico principal en las formas graves de gastroenteritis aguda (GEA) en la infancia. Material y métodos Estudio prospectivo de la incidencia y coste de GEA adquirida en la comunidad en menores de 5 años. Resultados Rotavirus fue el agente etiológico más frecuente. La incidencia acumulada de hospitalización por esta causa disminuyó a lo largo del periodo del estudio. Conclusiones Rotavirus es la causa más frecuente de GEA adquirida en la comunidad que requiere ingreso hospitalario en el área de Fuenlabrada (Madrid) (AU)

Introduction: Rotavirus is the main aetiological agent of severe acute gastroenteritis in childhood. Material and methods: A prospective study on the incidence and cost of acute gastroenteritis in childrenunder 5 years. Results: Rotavirus was the most frequent aetiological agent. The cumulative incidence of hospitalisation decreased over the study period.Conclusions: Rotavirus is the most common cause of acute community acquired gastroenteritis requiring hospital admission in the area of Fuenlabrada (Madrid) (AU)

[Epidemiology of community-acquired rotavirus gastroenteritis in Fuenlabrada (Madrid)]. / Epidemiología de la gastroenteritis por rotavirus adquirida en la comunidad en el área de Fuenlabrada (Madrid).

INTRODUCTION: Rotavirus is the main aetiological agent of severe acute gastroenteritis in childhood. MATERIAL AND METHODS: A prospective study on the incidence and cost of acute gastroenteritis in children under 5 years. RESULTS: Rotavirus was the most frequent aetiological agent. The cumulative incidence of hospitalisation decreased over the study period. CONCLUSIONS: Rotavirus is the most common cause of acute community acquired gastroenteritis requiring hospital admission in the area of Fuenlabrada (Madrid).

Insights into genotype-phenotype correlation in hypertrophic cardiomyopathy. Findings from 18 Spanish families with a single mutation in MYBPC3.

BACKGROUND: Mutations in the cardiac myosin-binding protein C (MYBPC3) gene are frequently found as a cause of hypertrophic cardiomyopathy (HCM). However, only a few studies have analysed genotype-phenotype correlations in small series of patients. The present study sought to determine the clinical characteristics, penetrance and prognosis of HCM with an identical mutation in MYBPC3. METHODS: 154 non-related patients with HCM (aged 55±16 years, 100 (64.9%) males) were studied. 18 (11.7%) were found to have an identical mutation in the MYBPC3 gene (IVS23+1G→A). Pedigree analysis, including both clinical evaluation and genotyping, was performed. RESULTS: 152 individuals (mean age 37±18 years, 53.3% males) from 18 families were evaluated. 65 carriers of the IVS23+1G→A mutation were identified, 61.5% of whom met HCM diagnostic criteria. Penetrance of the disease increased with age, with 50% affected at 46 years of age. Males tended to develop the disease earlier than females. 7 (15.6%) had systolic dysfunction. Compared with the rest of the HCM cohort, probands with the mutation had more hypertrophy and were younger at diagnosis. There was a trend towards a reduced survival free from sudden death (SD) (HR 1.71; 95% CI 0.98 to 2.98, p=0.059). There were 17 SD cases in 12 families with the mutation. CONCLUSIONS: The MYBPC3 IVS23+1G→A mutation is associated with middle-age onset disease and poor outcome, with a significant proportion of patients developing systolic impairment and a high SD risk profile.

Efectividad de las intervenciones para la prevención de caídas en ancianos: revisión sistemática / Effectiveness of interventions for prevention falls in the elderly: systematic review

Objetivos: identificar las principales causas por las que se producen las caídas y determinar qué medidas son efectivas y cuáles no en la prevención de caídas accidentales. Métodos: revisión sistemática sobre los diferentes estudios de caídas en el hospital. Esta revisión incluye ensayos clínicos, estudios de casos/controles, estudios de cohortes y estudios observacionales publicados desde la indexación de cada base de datos, hasta diciembre de 2009. Resultados: se revisó un total de 60 estudios, de los cuales 37 finalmente entraron en la revisión, previo examen de su calidad metodológica mediante el CASP. Las principales causas por las que se producen las caídas están relacionadas con la edad, patologías (Parkinson,demencias, Alzheimer), medicación y el pre/postope -ratorio. De todos los estudios, hay diversas intervenciones que han demostrado ser efectivas y reducir el número de caídas. Conclusiones: todos los estudios, en general, han aplicado medidas de prevención en función del riesgo y/o enfermedad identificados por grupos de pacientes. Las medidas preventivas que han demostrado eficacia han sido el uso correcto de la colocación de medidas de protección, el establecimiento de unos parámetros para la identificación de los posibles factores de riesgo que puedan ocasionar una caída y evaluar la (..) (AU)

Aims: to identify the main causes of falls and determine which interventions are effective to prevent accidental falls. Methods: Systematic review over studies of falls in the hospital. This review includes clinical trials, case/control, cohort and observational studies published since each database indexing until December 2009.Results: we reviewed a total of 60 studies; of these, 37 were eventually included in the review after conductingan analysis of their methodological quality using theCASP. The main causes of falls are related to age, chronicdisease (Parkinson’s, dementia, Alzheimer’s), medication and pre/post operative. There are several interventions thathave proven to be effective and reduce the number of falls.Conclusions: all studies have generally applied preventive interventions based on identified risk and /or disease ingroups of patients. Preventive interventions that have proven efficacy are: the correct use of the placement of protective elements, establishing parameters for the identification of possible risk factors that could cause a fall; evaluate the frequency of falls; to establish a scale of care dependence and compare it with the model of risk factors; analyze extrinsic risk factors favoring falls; use a score to identify patients at high risk, to establish a falls intervention program and develop strategies for prevention (..) (AU)

Granulocitoaféresis: a propósito de tres casos / No disponible

No disponible

Valoración del riesgo de exposicióna medicamentos citostáticos en elHospital General de Ciudad Real / Valoration of the risk of exposition to cytostatic medications in the Hospital of Ciudad Real

Durante el año 2007-2008, se realiza un estudio del riesgo de exposición a medicamentos citostáticos para valorar: Las áreas en las cuales se manipulan citostáticos ,las tareas con riesgo de exposición, el personal expuesto en cada uno de los procedimientos de trabajo y los EPIs que se utilizan en cada tarea, con la finalidad de determinar las medidas preventivas a adoptar tanto colectivas como individuales, para minimizar el riesgo de exposición de los trabajadores en toda la cadena de manipulación de citostáticos (AU)

During the year 2007-2008, is carried out a study from the exposition risk to cytostatic medications to value: The areas in which are manipulated cytostatic, the tasks with exposition risk, the personnel exposed in each one of the working up and the EPIs that are used in each task, with the purpose of determining the preventive measures so much collective as singular to adopt to minimize the risk of the workers’ exposition in the whole chain of manipulation of cytostatic (AU)