Feasibility of a Brief Online Mindfulness and Compassion-Based Intervention to Promote Mental Health Among University Students During the COVID-19 Pandemic.

Objectives: The COVID-19 pandemic constitutes a global mental health challenge that has disrupted the lives of millions of people, with a considerable effect on university students. The aim of this study was to assess the feasibility of a brief online Mindfulness and Compassion-based Intervention to promote mental health among first year university students during COVID-19 home confinement. Methods: Participants (n=66) were first-year psychology students from a university in Spain with no prior meditation experience. Intervention lasted for 16 days and was designed ad-hoc. Using a pre-post within-subjects design, feasibility was assessed in five domains (acceptability, satisfaction, implementation, practicality, and limited efficacy testing). Participants completed both baseline and post-intervention assessments of perceived stress, anxiety, and self-compassion. Results: The intervention showed to be feasible in all domains evaluated. It was implemented as planned with constrained resources, and limited efficacy testing showed promising results. After the intervention, stress and anxiety levels decreased significantly (p<0.001, Hedges's g=0.5146; p<0.001, Hedges's g=0.6068, respectively) whereas self-compassion levels were augmented significantly (p<0.001, Hedges's g=0.6968). Conclusions: Our findings suggest that a brief online mindfulness and compassion intervention may be a feasible way of promoting mental health among university students during COVID-19 lockdown. Further studies are required to address the limitations of the present study. We conclude that online interventions may constitute a promising pathway to buffer the mental health burden derived from the COVID-19 pandemic.

Oral Anticoagulation and Risk of Symptomatic Hemorrhagic Transformation in Stroke Patients Treated With Mechanical Thrombectomy: Data From the Nordictus Registry.

Introduction: We aimed to evaluate if prior oral anticoagulation (OAC) and its type determines a greater risk of symptomatic hemorrhagic transformation in patients with acute ischemic stroke (AIS) subjected to mechanical thrombectomy. Materials and Methods: Consecutive patients with AIS included in the prospective reperfusion registry NORDICTUS, a network of tertiary stroke centers in Northern Spain, from January 2017 to December 2019 were included. Prior use of oral anticoagulants, baseline variables, and international normalized ratio (INR) on admission were recorded. Symptomatic intracranial hemorrhage (sICH) was the primary outcome measure. Secondary outcome was the relation between INR and sICH, and we evaluated mortality and functional outcome at 3 months by modified Rankin scale. We compared patients with and without previous OAC and also considered the type of oral anticoagulants. Results: About 1.455 AIS patients were included, of whom 274 (19%) were on OAC, 193 (70%) on vitamin K antagonists (VKA), and 81 (30%) on direct oral anticoagulants (DOACs). Anticoagulated patients were older and had more comorbidities. Eighty-one (5.6%) developed sICH, which was more frequent in the VKA group, but not in DOAC group. OAC with VKA emerged as a predictor of sICH in a multivariate regression model (OR, 1.89 [95% CI, 1.01-3.51], p = 0.04) and was not related to INR level on admission. Prior VKA use was not associated with worse outcome in the multivariate regression model nor with mortality at 3 months. Conclusions: OAC with VKA, but not with DOACs, was an independent predictor of sICH after mechanical thrombectomy. This excess risk was associated neither with INR value by the time thrombectomy was performed, nor with a worse functional outcome or mortality at 3 months.

Health-related quality of life of people living with HIV infection in Spain: a gender perspective.

Studies exploring gender differences in health-related quality of life (HRQOL) of people living with HIV/AIDS (PLWHA) are scarce and contradictory. This study evaluated gender differences in HRQOL of 744 PLWHA with median (IQR) age 44 (37-48) years and HIV infection diagnosed 12 (5-20) years earlier. Results showed important differences between genders (p < .05). Better male physical health was related to being employed, not having economic worries, not receiving psychological support, not having injected drugs in past, low negative mood HIV-related, low HIV illness representation and internalized stigma, and high body image satisfaction and health behavior. For women, variables were fewer years since HIV diagnosis and low enacted stigma-personal experience of rejection. Mentally, variables in men were being employed, not having injected drugs, having a stable partner, high health behavior, use of problem-solving coping, personal autonomy and personal meaning. In women, better mental health was related to high CD4 cells, self-esteem and body image satisfaction, and negative mood HIV-related. Men and women coincided in absence of past opportunistic infections being related to better physical and mental health, and absence of side effects for physical health and low HIV-related stress and HIV illness representation for mental health. Our results highlight the need for detailed study of gender differences that identify the bio-psycho-socio inequalities that affect HRQOL.

Field Psychometric Testing of the Instrument for Assessment of Psychological Predictors of Well-Being and Quality of Life in People with HIV or AIDS.

The Screenphiv, a screening measure for psychological issues related to HIV, was psychometrically tested in a study involving 744 HIV-infected people in Spain. Participants ages 18-82 (M = 43.04, 72 % men, 28 % women) completed an assessment protocol that included the Screenphiv and the MOS-HIV. A trained interviewer also collected relevant illness-related clinical data and socio-demographics from the participants. A confirmatory factor analysis was used to evaluate the goodness of fit of the Screenphiv's theoretical model and confirmed six first-order factors and two second-order factors [RMSEA (IC 90 %) = 0.07 (0.07-0.08)]. No floor or ceiling effects were observed for the scores. Cronbach's alphas were acceptable for all of the factors (from 0.65 to 0.92). Criterion-related validity also achieved; Screenphiv scores were related to socio-demographic and clinical variables and MOS-HIV summary scores. The Screenphiv is a reliable and valid measure, ready to use in research and clinical settings in Spain.

A Spanish Study on Psychological Predictors of Quality of Life in People with HIV.

In Spain little research has focused on assessment of health indicators, both physical and psychological, in people living with HIV. The aim of this study is to evaluate a set of different indicators that allow us to identify psychological factors that may be influencing the quality of life of these people. The sample consist of 744 people infected with HIV aged between from 18 to 82 years (M = 43.04; SD = 9.43). Results show that factors such as self-esteem and leading a healthy lifestyle act as protectors in both, physical and mental health. On the other hand, financial problems, body disfigurement, and depressive mood could have harmful effects on both, physical and mental health. The structural model reveals depressed mood as the factor with greatest influence upon mental health, which in turn can be largely explained by factors such as the stress generated by HIV and personal autonomy. This work has allowed us to identify the vulnerability and protective factors that play a significant role in the physical and mental HRQOL of persons with HIV, providing guidelines for design and implementation of psychological intervention programs aimed to improve HRQOL in this population.

Infecciones endovasculares por Campylobacter: a propósito de dos casos / Endovascular Campylobacter infections: report of two cases

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Effectiveness of Mindfulness-Based Cognitive Therapy on the Quality of Life, Emotional Status, and CD4 Cell Count of Patients Aging with HIV Infection.

Long-term diagnosed and treated HIV-infected patients have to cope with a wide range of challenges that threaten their ability to age successfully. We report the results of a randomized controlled trial testing the effects of a mindfulness-based cognitive therapy (MBCT) program on quality of life (QoL), emotional status, and immune status over a 3-month period. Forty HIV-infected patients diagnosed prior to 1996 and on cART for a minimum of 5 years were randomized to follow an MBCT program (n = 20) or remain as controls (routine follow-up) (n = 20). A regression analysis was performed, and the measurement of effect size was estimated using Cohen's d. QoL, psychological stress, depressive symptoms, and anxiety symptoms improved in the MBCT group compared with the control group. During follow-up, patients in the MBCT group had a significantly increased CD4 cell count. Effect sizes for MBCT on the variables assessed were large (d = 0.8). The findings suggest that this program may help to promote successful aging in these patients.

Development of a new instrument for the assessment of psychological predictors of well-being and quality of life in people with HIV or AIDS.

This study aims to develop an instrument for the assessment of psychological predictors of well-being and quality of life (QoL) in people living with HIV. A four-step procedure was followed to achieve this objective. A literature review, focus group in different regions of Spain and content analysis generated a preliminary pool of 96 items. Interjudgement ratings over the items and a cognitive debriefing interview were performed to delete or review items (one omitted and 15 reviewed). The psychometric properties of the instrument were assessed in a sample of 84 HIV+. Pilot testing allowed a new wave of depuration process by empirical criteria (30 items omitted). A final pool of 63 items covering 23 facets (α from 0.53 to 0.95) of psychological predictors remained. Exploratory factorial analysis (GLS) assessing the underlying structure of the questionnaire showed a six-factor model explaining 56.5 of variance. Empirical exploratory structure revealed evidence of goodness of fit (χ(2) = 113.110, gl = 130, p > 0.05; RMSEA = 0.017; RMSEA IC90 % 0.000-0.057). This study presents the first instrument able to screen key psychological variables expected to be related to adjustment, well-being and QoL in people with HIV.

Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment.

This study explores the role of psychological stress in the circulating levels of interleukin-6 (IL-6) in a group of HIV-1 infected individuals on effective cART. We developed a cross-sectional study with 50 individuals with confirmed diagnosis of HIV-1 infection ≥1 and ≤8 years, on continuous cART for >1 and <8 years and with plasma viral load <50 copies/mL for at least 1 year. Clinical, behavioral and psychological variables were collected to control their possible indirect contribution in the relationship between psychological stress and IL-6. Pearson correlation and univariate/multivariate logistic regressions were performed. Eighty-eight percent of the subjects were male: median (IQR) age: 39.0 (32.7-42.2), years since HIV-1 infection: 3.4 (2.1-7.0), years on cART: 2.5 (1.6-5.7), CD4 cell count: 709.0 (573.5-881.0) cell/mm(3), plasma levels of IL-6: 7.0 (0-12.2) pg/ml. A strong correlation between IL-6 and psychological stress was found (r=.81). Psychological stress (coef: 0.49; SD: 0.05), anxiety/depression (0.37; 0.08) and unhealthy diet (2.94; 1.38) were associated with higher levels of IL-6. In the multivariate model psychological stress remained strongly associated with IL-6 (R(2): 59%). In conclusion, individuals with psychological stress presented high levels of IL-6 and psychological stress was the only variable which remained strongly associated with IL-6. This strong relationship suggests evidence for a mechanism through which psychological stress might contribute to the health's impairment of HIV-infected individuals on effective cART.

Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease.

BACKGROUND: Bacterial colonisation in chronic obstructive pulmonary disease (COPD) contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD. METHODS: Patients with stable COPD consecutively recruited over 1 year gave consent to provide a sputum sample for microbiologic analysis. Bronchial colonisation by potentially pathogenic microorganisms (PPMs) was defined as the isolation of PPMs at concentrations of > or =102 colony-forming units (CFU)/mL on quantitative bacterial culture. Colonised patients were divided into high (>105 CFU/mL) or low (<105 CFU/mL) bacterial load. RESULTS: A total of 119 patients (92.5% men, mean age 68 years, mean forced expiratory volume in one second [FEV1] [% predicted] 46.4%) were evaluated. Bacterial colonisation was demonstrated in 58 (48.7%) patients. Patients with and without bacterial colonisation showed significant differences in smoking history, cough, dyspnoea, COPD exacerbations and hospitalisations in the previous year, and sputum colour. Thirty-six patients (62% of those colonised) had a high bacterial load. More than 80% of the sputum samples with a dark yellow or greenish colour yielded PPMs in culture. In contrast, only 5.9% of white and 44.7% of light yellow sputum samples were positive (P < 0.001). Multivariate analysis showed an increased degree of dyspnoea (odds ratio [OR] = 2.63, 95% confidence interval [CI] 1.53-5.09, P = 0.004) and a darker sputum colour (OR = 4.11, 95% CI 2.30-7.29, P < 0.001) as factors associated with the presence of PPMs in sputum. CONCLUSIONS: Almost half of our population of ambulatory moderate to very severe COPD patients were colonised with PPMs. Patients colonised present more severe dyspnoea, and a darker colour of sputum allows identification of individuals more likely to be colonised.

Neuropsychiatric symptoms associated with efavirenz: prevalence, correlates, and management. A neurobehavioral review.

The non-nucleoside analog reverse transcriptase inhibitor efavirenz is one of the most common components of HAART. Neuropsychiatric symptoms are frequently reported in patients taking efavirenz-based regimens. These symptoms are usually transient, although they can sometimes persist for up to two years after initiation of treatment. This review describes in detail the most common neuropsychiatric symptoms related to efavirenz, outlines relevant and recent findings on this agent, and suggests possible interventions based on neurobehavioral results. Different recommendations on the assessment of efavirenz-related adverse events are also provided.

Empatía en una muestra española de delincuentes sexuales / Study of empathy in a Spanish sex offender sample

La investigación internacional ha evidenciado la relevancia de la variable empatía en la agresión sexual. El objetivo de este estudio es explorar, en una muestra española de delincuentes, la relación déficit en empatía-agresión sexual para diferentes tipos de víctimas, así como los posibles beneficios del tratamiento psicológico en la mejora de esta variable. Para evaluar la empatía se tradujo y adaptó al castellano la Rape Empathy Measure y se aplicó a un grupo de 118 delincuentes no-sexuales y a otro de 73 violadores, 39 tratados y 34 no-tratados. Los principales resultados obtenidos ponen de manifiesto que los violadores no-tratados puntúan más bajo en empatía que los delincuentes no-sexuales; sin embargo, los violadores tratados superan en empatía tanto a los violadores no-tratados como a los delincuentes no-sexuales. Estos resultados son parcialmente coherentes con los de otras investigaciones precedentes. Para finalizar se comenta la conveniencia de evaluar en futuros estudios tanto la variable empatía como otras variables psicológicas conectadas con la agresión sexual

International research has emphasised that empathy is a relevant factor of sex offending. The main goal of this study is to explore, in a Spanish sex offender sample, the relationship between empathy deficits and sex crime for various types of victims. This study also analyses the positive effect that psychological treatment could have on empathy. For this purpose, 118 non-sex offenders were compared on an adapted version of Rape Empathy Measure to 39 treated rapists and 34 untreated rapists. Results show that the untreated rapists have lower empathy levels than non-sex offenders. Nevertheless, the treated rapists scored higher on empathy than the other two groups assessed, untreated rapists and non-sex offenders. Lastly, some suggestions are provided for future research in terms of the assessment of empathy and other factors related to sexual aggression

[Study of empathy in a Spanish sex offender sample]. / Empatía en una muestra española de delincuentes sexuales.

International research has emphasised that empathy is a relevant factor of sex offending. The main goal of this study is to explore, in a Spanish sex offender sample, the relationship between empathy deficits and sex crime for various types of victims. This study also analyses the positive effect that psychological treatment could have on empathy. For this purpose, 118 non-sex offenders were compared on an adapted version of Rape Empathy Measure to 39 treated rapists and 34 untreated rapists. Results show that the untreated rapists have lower empathy levels than non-sex offenders. Nevertheless, the treated rapists scored higher on empathy than the other two groups assessed, untreated rapists and non-sex offenders. Lastly, some suggestions are provided for future research in terms of the assessment of empathy and other factors related to sexual aggression.

[Recidivism risk assessment in sex offenders]. / Predicción de riesgo de reincidencia en agresores sexuales.

Violent behaviour risk assessment is one of the most relevant research areas in current Psychology of Crime. Various scales for violence risk assessment have recently been developed from research about crime careers and risk factors. One of these instruments is the Sexual Violence Risk Assessment-20 (SVR-20), translated and adapted to Spanish by the Group of Advanced Studies in Violence of the University of Barcelona. The goal of this study is to verify the predictive capacity of the SVR-20 to predict sexual violence recidivism in a Spanish sample of sexual offender inmates. The method used was a retrospective study based in 163 sexual offender files and a 4-year time lag. The data were analysed with the logistic regression technique. Of the sample, 79.9% non-recidivist individuals were correctly classified, and 70.8% recidivist individuals. The ROC curve obtained for the model shows a very good discriminant capacity for the SVR-20, with a 0.83 AUC value. The main conclusion of this study is that the Spanish adaptation of SVR-20 is a good instrument to predict the risk of sexual violence.

Predicción de riesgo de reincidencia en agresores sexuales / Recidivism risk assessment in sex offenders

La evaluación del riesgo de conducta violenta es un campo emergente en la actual Psicología de la Delincuencia. A partir de la investigación sobre carreras criminales y predictores de riesgo, durante los últimos años se han desarrollado diferentes escalas de evaluación del riesgo de violencia. Uno de estos instrumentos es el Sexual Violence Risk Assessment-20 (SVR-20), traducido y adaptado al español en el Grupo de Estudios Avanzados en Violencia de la Universidad de Barcelona. El objetivo de este estudio es evaluar la capacidad del SVR-20 para predecir la reincidencia sexual en una muestra española de delincuentes sexuales. Para ello se ha aplicado el SVR-20 de forma retrospectiva a un grupo de 163 agresores sexuales ya excarcelados. La capacidad discriminativa del instrumento ha sido evaluada a través del modelo de regresión logística. Se obtuvo un porcentaje de clasificaciones correctas de los sujetos no reincidentes del 79,9% y de los sujetos reincidentes del 70,8%. La curva ROC obtenida muestra una buena capacidad discriminativa del SVR-20 con un valor de área bajo la curva (AUC) de 0.83. La principal conclusión de este estudio es que el SVR-20 es un instrumento de utilidad para mejorar los pronósticos de riesgo de violencia sexual

Violent behaviour risk assessment is one of the most relevant research areas in current Psychology of Crime. Various scales for violence risk assessment have recently been developed from research about crime careers and risk factors. One of these instruments is the Sexual Violence Risk Assessment-20 (SVR-20), translated and adapted to Spanish by the Group of Advanced Studies in Violence of the University of Barcelona. The goal of this study is to verify the predictive capacity of the SVR-20 to predict sexual violence recidivism in a Spanish sample of sexual offender inmates. The method used was a retrospective study based in 163 sexual offender files and a 4-year time lag. The data were analysed with the logistic regression technique. Of the sample, 79.9% non-recidivist individuals were correctly classified, and 70.8% recidivist individuals. The ROC curve obtained for the model shows a very good discriminant capacity for the SVR-20, with a 0.83 AUC value. The main conclusion of this study is that the Spanish adaptation of SVR-20 is a good instrument to predict the risk of sexual violence