Angioleiomioma renal con patrón inmunohistoquímico miogénico y melanocítico como variante del angiomiolipoma / Renal angioleiomyoma with a myogenic and melanocytic immunophenotype, as a variant of angiomyolipoma

Se presenta el caso de un varón de 67 años con tumoración cortical nodular renal izquierda. Fue intervenido quirúrgicamente por crecimiento tumoral progresivo de 16-20mm a lo largo de un año y tras seguimiento por estudio ecográfico y de resonancia magnética. Se practicó tumorectomía del nódulo y en el examen microscópico se observó una formación bien delimitada y no encapsulada, resultante de proliferación tumoral de células fusiformes sin atipias y de apariencia muscular lisa, que adoptaban disposición arremolinada junto a zonas ricamente vascularizadas. En el estudio inmunohistoquímico, en la proliferación fusocelular se demostró positividad para marcadores musculares (actina de músculo liso, desmina y caldesmón) y marcadores melanocíticos (HMB-45 y Melan A). Nuestro caso parece tratarse de una neoplasia renal de patrón angioleiomiomatoso, pero con características inmunohistoquímicas de angiomiolipoma (PEComa) sin componente lipomatoso o lipídico, tipo de tumoración sobre la que no poseemos información previa en la literatura revisada

We present a case of a 67 year old male with a cortical nodular tumour of the left kidney. During a year's follow-up with ultrasound and MRI, the tumour was seen to increase in size by 16-20 mm. The nodule was surgically removed. Microscopically it was well defined and unencapsulated, with a proliferation of typical fusiform cells of smooth muscle cell appearance, clumped around well vascularized areas. Immunohistochemically, the neoplasm was positive for muscle markers (smooth muscle actin, desmin and caldesmon) and melanocyte markers (HMB-45 and Melan A). Our case would appear to be a renal neoplasm with an angioleiomyomatous pattern, but with immunohistochemical characteristics of angiomyolipoma (PEComa), however, without either a lipomatous or lipid cell component. We found no previous reports of this type of tumour in the literature

[Renal angioleiomyoma with a myogenic and melanocytic immunophenotype, as a variant of angiomyolipoma]. / Angioleiomioma renal con patrón inmunohistoquímico miogénico y melanocítico como variante del angiomiolipoma.

We present a case of a 67 year old male with a cortical nodular tumour of the left kidney. During a year's follow-up with ultrasound and MRI, the tumour was seen to increase in size by 16-20 mm. The nodule was surgically removed. Microscopically it was well defined and unencapsulated, with a proliferation of typical fusiform cells of smooth muscle cell appearance, clumped around well vascularized areas. Immunohistochemically, the neoplasm was positive for muscle markers (smooth muscle actin, desmin and caldesmon) and melanocyte markers (HMB-45 and Melan A). Our case would appear to be a renal neoplasm with an angioleiomyomatous pattern, but with immunohistochemical characteristics of angiomyolipoma (PEComa), however, without either a lipomatous or lipid cell component. We found no previous reports of this type of tumour in the literature.

Linitis-like squamous esophageal cancer diagnosed by endoscopic ultrasonography-guided fine-needle aspiration cytology: report of two cases.

Endoscopic ultrasonography-guided fine-needle aspiration cytology (EUS-FNA) may provide full-thickness biopsies, adequate for cytology and histology. In the present case report, we describe the first cases of a rare well-differentiated squamous esophageal carcinoma (verrucous esophageal cancer), finally diagnosed by EUS-FNA using a large FNA needle after several upper endoscopies with biopsies negative for malignancy. In this report, we highlight the usefulness of this procedure and EUS features in the diagnosis of suspicious esophageal lesions with negative endoscopic biopsies for malignancy.

Diagnóstico prenatal de un caso de trisomía 8 mosaico, asociado a la existencia de un quiste unilateral de plexos coroideos / Prenatal diagnosis of trisomy 8 mosaicism associated with unilateral chroroid plexus cyst

Presentamos un caso de trisomía del cromosoma 8 mosaico, diagnosticado mediante citogenética con técnicas de hibridación in situ con fluorescencia (FISH) tras amniocentesis a las 18 semanas de la gestación, en una paciente que en el estudio ecográfico mostró imágenes de quiste unilateral de los plexos coroideos, así como un hemangioma placentario. Se hace una valoración de los hallazgos fenotípicos fetales en el estudio necrópsico, que se comparan con los descritos en diferentes casos de trisomías totales y/o parciales del cromosoma 8, y se valora muy especialmente la relación existente entre la presencia de quistes de los plexos coroideos y la aparición de cromosomopatías(AU)

We report a case of trisomy 8 mosaicism, diagnosed by FISH (fluorescent in situ hibridization) after 18 week pregnancy amniocentesis, in a patient whose ultrasound scan showed a unilateral choroid plexus cyst and placental haemangioma. We assessed the foetopathological examination, comparing it with different cases of total and partial trisomies of chromosome 8, paying special attention to the relationship between choroid plexus cyst and chromosomopathies(AU)

Linfoma pancreático primario diagnosticado mediante punción aspiración con aguja guiada por ultrasonografía endoscópica / Primary pancreatic lymphoma diagnosed by endoscopic ultrasound-guided fine needle aspiration biopsy

Aunque el linfoma pancreático primario (LPP) es un tumor maligno infrecuente, el diagnóstico correcto es fundamental ya que su manejo terapéutico difiere del de otros tumores pancreáticos. La punción aspiración con aguja fina guiada por ultrasonografía endoscópica (USE-PAAF) es actualmente la técnica de elección para el diagnóstico de neoplasias de páncreas, resultando de especial utilidad en aquellas lesiones de características o presentación atípica. Sin embargo, la utilidad de la USE-PAAF en el LPP ha sido poco estudiada debido a la rareza de esta entidad. Se presenta un caso de un paciente con infección VIH y LPP diagnosticado mediante USE-PAAF (AU)

Although primary pancreatic lymphoma (PPL) is a rare malignant tumor, the correct diagnosis is essential since their therapeutic management differs from other pancreatic tumors. The fine needle aspiration cytology guided by endoscopic ultrasonography (EUS-FNA) is currently the preferred technique for the diagnosis of neoplasms of the pancreas, being of particular interest in those pancreatic lesions with atypical characteristics or presentation. However, the usefulness of EUS-FNA in the PPL has been poorly studied because of the rarity of this entity. We report a case of a patient with HIV infection and PPL diagnosed by EUS-FNA (AU)

[Primary pancreatic lymphoma diagnosed by endoscopic ultrasound-guided fine needle aspiration biopsy]. / Linfoma pancreático primario diagnosticado mediante punción aspiración con aguja guiada por ultrasonografía endoscópica.

Although primary pancreatic lymphoma (PPL) is a rare malignant tumor, the correct diagnosis is essential since their therapeutic management differs from other pancreatic tumors. The fine needle aspiration cytology guided by endoscopic ultrasonography (EUS-FNA) is currently the preferred technique for the diagnosis of neoplasms of the pancreas, being of particular interest in those pancreatic lesions with atypical characteristics or presentation. However, the usefulness of EUS-FNA in the PPL has been poorly studied because of the rarity of this entity. We report a case of a patient with HIV infection and PPL diagnosed by EUS-FNA.