Asunto(s)
Anafilaxia , Alérgenos , Anafilaxia/diagnóstico , Anafilaxia/etiología , Animales , Peces , HumanosAsunto(s)
Antineoplásicos/uso terapéutico , Autoanticuerpos/sangre , Cetuximab/uso terapéutico , Desensibilización Inmunológica/métodos , Inmunoglobulina E/sangre , alfa-Galactosidasa/inmunología , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/inmunología , Carcinoma de Células Escamosas/secundario , Esquema de Medicación , Humanos , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/inmunología , Neoplasias Pulmonares/secundario , Masculino , Persona de Mediana Edad , Neoplasias Faríngeas/tratamiento farmacológico , Neoplasias Faríngeas/inmunología , Neoplasias Faríngeas/patología , Seno Piriforme/efectos de los fármacos , Seno Piriforme/inmunología , Seno Piriforme/patología , Pruebas Cutáneas , alfa-Galactosidasa/sangreAsunto(s)
Anomalías Múltiples/diagnóstico , Anafilaxia/diagnóstico , Capsicum/inmunología , Hipersensibilidad a los Alimentos/diagnóstico , Hipersensibilidad al Látex/diagnóstico , Anomalías Múltiples/inmunología , Adulto , Alérgenos/inmunología , Anafilaxia/inmunología , Antígenos de Plantas/inmunología , Reacciones Cruzadas , Femenino , Hipersensibilidad a los Alimentos/inmunología , Frutas/efectos adversos , Humanos , Immunoblotting , Inmunoglobulina E/inmunología , Hipersensibilidad al Látex/inmunología , SíndromeAsunto(s)
Anemia Aplásica/inmunología , Suero Antilinfocítico/inmunología , Desensibilización Inmunológica , Hipersensibilidad a las Drogas/terapia , Adolescente , Anemia Aplásica/complicaciones , Animales , Suero Antilinfocítico/administración & dosificación , Suero Antilinfocítico/efectos adversos , Hipersensibilidad a las Drogas/etiología , Hipersensibilidad a las Drogas/inmunología , Femenino , Humanos , Conejos , Pruebas Cutáneas , Trombocitopenia/etiologíaRESUMEN
Type IV hypersensitivity eye reactions have been described after the administration of the sympathomimetic agent phenylephrine. We report the case of an atopic woman who developed nasal congestion and discharge, dysphagia, and dyspnea 1 hour after the administration of Stopcold pills and Disneumon Pernasal nasal spray for otitis. The same symptoms reappeared after the accidental administration of Rinobanedif ointment in the nasal mucosa. Skin patch tests were performed with a standard True Test panel, preservatives, Disneumon Pernasal, pseudoephedrine, eyedrops (tropicamide, cyclopentolate, and phenylephrine), and other sympathomimetic agents. The patient also underwent oral, ocular, and nasal controlled challenges with the same drugs. Finally, patch tests were performed in 11 controls with phenylephrine and ethylephrine. Our patient had a positive outcome in patch testing with nickel sulphate, fragrance mix, phenylephrine, and ethylephrine. To our knowledge, this is the first report of a type IV reaction to nasally administered phenylephrine with cross-reactivity with ethylephrine detected by patch testing.
Asunto(s)
Hipersensibilidad a las Drogas/etiología , Hipersensibilidad Tardía/etiología , Fenilefrina/efectos adversos , Simpatomiméticos/efectos adversos , Administración Intranasal , Reacciones Cruzadas , Diagnóstico Diferencial , Hipersensibilidad a las Drogas/diagnóstico , Etilefrina/administración & dosificación , Etilefrina/efectos adversos , Etilefrina/uso terapéutico , Femenino , Humanos , Hipersensibilidad Tardía/diagnóstico , Persona de Mediana Edad , Pruebas del Parche , Fenilefrina/administración & dosificación , Fenilefrina/uso terapéutico , Simpatomiméticos/administración & dosificación , Simpatomiméticos/uso terapéuticoAsunto(s)
Antibacterianos/efectos adversos , Hipersensibilidad a las Drogas/etiología , Forunculosis/tratamiento farmacológico , Ácido Fusídico/efectos adversos , Urticaria/etiología , Administración Oral , Administración Tópica , Adulto , Antibacterianos/administración & dosificación , Hipersensibilidad a las Drogas/diagnóstico , Femenino , Ácido Fusídico/administración & dosificación , Humanos , Pruebas Cutáneas , Urticaria/diagnósticoAsunto(s)
Proteínas Portadoras/efectos adversos , Hipersensibilidad a los Alimentos/etiología , Petroselinum/efectos adversos , Adulto , Proteínas Portadoras/química , Proteínas Portadoras/inmunología , Femenino , Hipersensibilidad a los Alimentos/diagnóstico , Humanos , Petroselinum/química , Petroselinum/inmunología , Pruebas CutáneasRESUMEN
Because seafood consumption is moderate-to-high in Spain, allergic reactions to seafood such as fish, crustacea and mollusc are fairly frequent. The clinical features of these reactions depend on the implicated species and whether the reaction is provoked by ingestion, handling or vapor inhalation. Because different species have common antigenic structures, cross-sensitization is frequent, especially between crustaceans and molluscs. Contamination of fish by nematodes (Anisakis) may produce severe reactions. We report the case of a female patient with no personal or family history of allergy who experienced two episodes of anaphylactic shock: the first occurred immediately after eating oysters and the second after ingestion of white fish. The patient also developed generalized urticaria provoked by crustacean (prawns) and white fish. The results of skin prick tests were negative for fish, shellfish, crustacean and oysters while in vitro tests were positive for oyster, prawns, Anisakis, Ascaris and Echinococcus, although stool samples and gastric endoscopy were negative.
Asunto(s)
Anafilaxia/etiología , Anisakis , Decápodos , Peces/parasitología , Hipersensibilidad a los Alimentos/etiología , Ostreidae , Alimentos Marinos/efectos adversos , Urticaria/etiología , Alérgenos , Animales , Anisakis/inmunología , Ascaris/inmunología , Niño , Reacciones Cruzadas , Decápodos/inmunología , Echinococcus/inmunología , Endoscopía del Sistema Digestivo , Femenino , Humanos , Persona de Mediana Edad , Ostreidae/inmunología , Pruebas CutáneasRESUMEN
Some members of the Anacardiaceae family, such as cashew nut, pistachio nut and mango, have been reported to cause immediate allergic reactions. We report three cases of anaphylaxis to cashew nuts. With the aim of describing the allergens existing in cashew and pistachio nuts, patients were prick tested with cashew and pistachio extracts. Specific IgE against both nuts was studied by CAP and SDS-PAGE/immunoblotting. It was found that skin tests and specific IgE to cashew and pistachio nuts were positive in the three patients. Both nuts showed several protein bands in SDS-PAGE. The strongest IgE-binding bands had similar molecular weights (15, 30 and 60 kDa) in cashew and pistachio nuts. These main bands were found to be sensitive to reducing agents. It was concluded that these three patients suffered immediate reactions to cashew nut due to an IgE-mediated mechanism.
Asunto(s)
Alérgenos/inmunología , Hipersensibilidad a los Alimentos/etiología , Nueces/inmunología , Árboles , Adulto , Niño , Femenino , Hipersensibilidad a los Alimentos/sangre , Hipersensibilidad a los Alimentos/inmunología , Hipersensibilidad a los Alimentos/fisiopatología , Humanos , Lactante , Pruebas CutáneasRESUMEN
BACKGROUND: Few cases of allergy to pine nuts have been described. We report a case of anaphylactic reaction to pine nuts. The patient needed to be treated in the emergency room due to a systemic reaction immediately after eating pine nuts. METHODS: The patient was studied by prick tests and prick by prick tests. Specific IgE was measured by CAP and by SDS-PAGE/immunoblotting by a diffusion method. RESULTS: The patient showed positive prick by prick tests to pine nuts (12 mm of maximum wheal diameter). Specific IgE was positive (0.79 kU/l). The patient's serum recognized several proteins by immunoblot. However, a 17-kDa allergen band was detected with high intensity. This protein was found to be sensitive to reducing agents, losing its IgE-binding properties after reduction. CONCLUSIONS: The patient presented an IgE-mediated reaction and detected a 17-kDa protein from pine nuts not previously described.