RESUMEN
Superinvasion opisthorchiasis is characterized by host growth retardation and weight reduction, which are due to the cleptoeffect of Opisthorchis felineus; metabolic disturbances, proliferative processes, accelerated collagen biosynthesis and biodegradation in the organs reflect parasite-host interactions as components of the system. The productive reactions of visceral pathology are initiated by the parasite's metabolites located in the liver, lung, heart, and testes.
Asunto(s)
Hígado/patología , Pulmón/patología , Opistorquiasis , Opisthorchis/crecimiento & desarrollo , Phodopus/parasitología , Testículo/patología , Adolescente , Adulto , Animales , Antropometría , Estatura , Estudios de Casos y Controles , Cricetinae , Corazón/parasitología , Histocitoquímica , Interacciones Huésped-Parásitos , Humanos , Hígado/parasitología , Pulmón/parasitología , Masculino , Malondialdehído/análisis , Metacercarias/crecimiento & desarrollo , Microscopía Electrónica de Transmisión , Opistorquiasis/metabolismo , Opistorquiasis/parasitología , Opistorquiasis/patología , Opistorquiasis/fisiopatología , Opistorquiasis/veterinaria , Federación de Rusia , Superóxido Dismutasa/análisis , Testículo/parasitologíaRESUMEN
Opisthorchis superinvasion retains the natural manifestations of reparative regeneration of skeletal tissues, but activates proliferation stages and increases the promoter manifestations of histogenesis. Irrespective of a surgical option, the rate of infestation, and the place of residence, reparative regeneration of shaft fractures of the shin and hip occurs significantly more rapidly in patients with superinvasion opisthorchiasis than in those without the latter. In superinvasion opisthorchiasis, bone is restituted by early callus formation and accelerated regenerate mineralization.
Asunto(s)
Regeneración Ósea , Calcificación Fisiológica , Fracturas de Cadera/metabolismo , Opistorquiasis/mortalidad , Fracturas de la Tibia/metabolismo , Femenino , Fracturas de Cadera/parasitología , Humanos , Masculino , Fracturas de la Tibia/parasitologíaRESUMEN
The study of the model of superinvasive opisthorchiasis (SO) in Syrian hamsters and autopsy material obtained from patients with SO, it was shown that during the early period of pulmonary disease, the lungs underwent changes developing on the basis of delayed-type hypersensitivity reactions. In the chronic phase of SO, exudative and predominant productive reactions were revealed leading to the interstitial lung disease, fibrosing alveolitis. In the heart in SO, eosinophilic cell myocarditis was found with subsequent diffuse cardiosclerosis. In the testes, sclerotic processes with atrophy of glandulocytes (Leydig cells) and sustentocytes (Sertoli cells) were detected. The structural changes in the lungs, heart and testes were induced by parasite metabolites, that are deposited in tissues in the form of granules and conglomerates.