Correlacionando icterícia, resultados de exames laboratoriais e diagnósticos de doenças / Correlating jaundice, laboratory test results and diagnosis of diseases

Para descobrir quais as doenças que mais comumente cursam com a icterícia em pacientes internados no Hospital Universitário Antônio Pedro (HUAP) e correlacioná-las com marcadores bioquímicos foram utilizados dados extraídos de prontuários de pacientes internados durante os anos de 2005 a 2007. 0s dados foram analisados usando métodos estatísticos como qui-quadrado e teste Z. Utilizamos a análise das dosagens de aspartato-aminotrans ferase (AST), alanina-aminotransferase (ALT), fosfatase alcalina (FA), gama-glutamiltransferase (gama-GT), bilirrubina (Bb) total e suas frações direta e indireta. Os sinais e sintomas mais comuns na amostra estudada foram: dor abdominal, vômitos e colúria, que estão presentes em cerca de 60% das queixas dos pacientes estudados. Na população entre nove e 85 anos de idade, a análise sugere que AST e ALT nos chamam atenção para uma possível lesão hepática associada aos casos de icterícia. Enquanto que FA e GGT são marcadores de colestase. A bilirrubina direta tem média mais elevada no grupo de pacientes entre nove e 85 anos e a bilirrubina indireta atinge níveis maiores no grupo com até dois meses de vida. As dosagens bioquímicas são armas muito importantes na pesquisa etiológica dos casos de icterícia.

To find out which diseases most commonly lead to jaundice in hospitalized patients in HUAP and correlate them with biochemical markers. We used data from medical records of patients hospitalized during the years 2005 to 2007. The data were analyzed using statistical methods to test and chi-square-Z. We used the analysis of the strengths of AST, ALI, FA, GGT, Bb and its fractions total direct and indirect. The most common signs and symptoms in the sample studied were abdominal pain, vomiting and choluria that are present in about 60% of complaints from patients. In the population between nine and 85 years of age, the analysis suggests that AST and ALT in calling attention to a possible liver damage linked to cases of jaundice. While FA and gamma-GT are markers of cholestasis. The direct bilirubin is highest average in the group of patients between nine and 85 years and indirect bilirubin levels higher in the group with up to two months of life. The biochemical doses are very important weapons in the etiological research of cases of jaundice.

Fetal acidemia prediction through short-term variation assessed by antepartum computerized cardiotocography in pregnant women with hypertension syndrome.

OBJECTIVE: To establish a cut-off value for short-term variation (STV) assessed by computerized cardiotocography (CTG) as a single parameter in the prediction of acidemia at birth. METHODS: Cross-sectional study performed on 41 single gestations with diagnosis of hypertension syndrome after the 27th week and delivered by elective cesarean. Computerized CTG examinations were 20-min long at most, and were performed up to 24 before delivery. Immediately after delivery, blood samples were collected from the umbilical cord vessels to determine pH. To establish a cut-off value, a receiver operator characteristics (ROC) curve was created with STV as independent variable and umbilical artery pH as dependent variable. Later, sensitivity (S), specificity (E), positive predictive value (PPV), and negative predictive value (NPV) were calculated for the cut-off value obtained. RESULTS: A significant correlation was found between STV and acidemia at birth, and STV values < or =5.25 ms were significantly capable of predicting acidemia (pH < 7.20) (S = 57.1%; E = 85.2%; PPV = 66.6%; NPV = 79.3%; P < 0.05). CONCLUSIONS: STV values of < or =5.25 ms could predict acidemia at birth in pregnant women with hypertension syndrome.