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1.
Eat Weight Disord ; 27(8): 3767-3771, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36040567

RESUMEN

PURPOSE: This study analyzes whether knowing that a male with obesity has a romantic relationship with a normal weight woman improves impressions about him. METHODS: An online experiment was conducted with a sample of 3024 adult participants (1828 women and 1196 men) with a mean age of 36.11 (SD = 13.49). Each participant was shown two photographs: one of a male target with obesity and one of his female partner (who had either normal weight or obesity depending on the condition). The respondents' sex was added as a fixed factor into the analyses. Physical attractiveness was rated using an item with a scale ranging from 0 to 100. Competence, warmth, and morality were measured using a 17-item adjective list. RESULTS: The target was assessed as more attractive when he had a partner with normal weight (F(1, 3009) = 4.85, p = .028, [Formula: see text] = .002), and was also given higher scores for competence (F(1, 3009) = 4.93, p = .026, [Formula: see text] = .002), warmth (F(1, 3009) = 4.32, p = .038, [Formula: see text] = .001), and morality (F(1, 3009) = 11.16, p = .001, [Formula: see text] = .004). There was a significant interaction between partner weight and the respondents' sex for physical attractiveness, as the difference between the scores in each condition was only significant for women. CONCLUSION: It is possible that women perceived that the male target who had a normal weight partner had a higher status or some hidden quality besides his physical appearance, and thus rated him as more attractive. LEVEL OF EVIDENCE: Level I, experimental study.


Asunto(s)
Actitud , Obesidad , Adulto , Humanos , Masculino , Femenino
2.
Artículo en Inglés | MEDLINE | ID: mdl-34501653

RESUMEN

The main objective of this study was to examine the consequences of perceived discrimination in people with hearing and visual impairments. Using path analysis, we attempted to validate a multigroup model in which perceived personal discrimination is associated with internalization of stigma, which, in turn, is negatively related to self-esteem; conversely, perceived discrimination against the in-group contributes to enhanced group identification, which promotes the intention to engage in collective action, which, in turn, has beneficial effects on self-esteem. The sample consisted of a total of 200 Spanish-speaking participants, of whom 104 had hearing impairments and 96 had visual impairments. The results showed that the proposed multigroup model fit the data well. For both groups, internalized stigma played a mediating role in the relationship between perceived personal discrimination and self-esteem. However, the pathway from group discrimination to self-esteem was not as clearly supported by the data. The results are interpreted from a psychosocial perspective and may contribute to design interventions aimed at improving the well-being of people with hearing and visual impairments.


Asunto(s)
Autoimagen , Estigma Social , Audición , Humanos , Identificación Social , Trastornos de la Visión
3.
Res Dev Disabil ; 105: 103737, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32679389

RESUMEN

BACKGROUND: People with autism spectrum disorders (ASD) and people with intellectual disabilities (ID) are stigmatized, and therefore discriminated against worldwide and, on many occasions, this stigma and discrimination are expanded to include their family caregivers. The main objective of this research was to examine the consequences of perceived discrimination on family caregivers of children with ASD and children with ID. METHODS: The sample consisted of 109 Spanish caregivers of children with ASD and 83 caregivers of children with ID. They completed four questionnaires: Multidimensional Perceived Discrimination Scale, Affiliate Stigma Scale, Social Support Questionnaire and Rosenberg Self-Esteem Scale. RESULTS: Using path analysis, we found support for a model in which personal discrimination perceived by caregivers was positively associated with affiliate stigma, which, in turn, was negatively related to caregivers' self-esteem. The model also shows the total mediational role of affiliate stigma in the association between perceived discrimination and self-esteem and the partial mediational role that social support plays in the association between perceived discrimination and caregivers' self-esteem. CONCLUSIONS: Caregivers' perceived discrimination negatively influences caregivers' self-esteem, but this relationship is mediated by both affiliate stigma (totally) and social support (partially). These results have theoretical and practical implications and may contribute to improving the quality of life of parents of children with ASD and ID that in turn would result in an improvement of the quality of life of their children.


Asunto(s)
Trastorno del Espectro Autista , Discapacidad Intelectual , Cuidadores , Niño , Humanos , Calidad de Vida , Estigma Social , Apoyo Social , España
4.
Gac. sanit. (Barc., Ed. impr.) ; 34(3): 268-275, mayo-jun. 2020. tab
Artículo en Español | IBECS | ID: ibc-196618

RESUMEN

Los fraudes financieros asociados a la crisis económica se han manifestado en los países desarrollados con efectos en la salud física, psíquica y social de las personas afectadas. A partir de los estudios cuantitativos y las revisiones de la literatura, este trabajo pretende obtener evidencias sobre los efectos en la salud a través de la narrativa de las personas entrevistadas. Se ha obtenido una muestra intencional de 32 personas afectadas por fraudes financieros (hipotecas abusivas y multidivisa, participaciones preferentes y swap) en Madrid, para realizar un análisis del contenido. Las personas afectadas tienen, en general, unas condiciones de edad, sexo, nivel educativo y profesión que les pueden haber permitido, en su curso de vida, acumular recursos económicos para suscribir productos financieros devenidos fraudulentos, basados en la confianza en las instituciones financieras. El fraude ha propiciado la aparición de procesos de anomia, agrandados con el tiempo, que se manifiestan con dolencias físicas (diversas enfermedades) y síntomas y patologías mentales (ansiedad, depresión, ideas de suicidio), que afectan al modo de vida, los hábitos y las relaciones personales y sociales, y que llegan a afectar a otros miembros de la familia. El aumento del consumo de fármacos y del uso de servicios de salud sirve de corolario al desajuste producido en su salud. Las personas afectadas y la sociedad española en su conjunto demandan medidas de política pública sanitaria para su atenuación y la recuperación de su confianza en el sistema bancario y político


During the economic crisis, developed countries have experienced financial fraud, with effects on the physical and mental health of the people affected, and on social domains. Based on the theoretical framework in literature reviews and in quantitative studies, this paper aims to obtain evidence on the effects of financial fraud on health and on the family and social environments of those affected. An intentional sample of 32 people affected by abusive and multi-currency mortgages, preferred and swap stock in Madrid was approached. In-depth interviews were conducted, and the resulting data was analysed using content analysis. Fraud-affected individuals had conditions of age, sex, educational level and occupations that possibly allowed them to accumulate economic resources throughout the course of their lives and, predictably in many cases, to take out fraudulent financial products, based on trust in the financial institutions. Financial fraud has led to the emergence of various processes of anomia and adverse health effects. The consequences on health were physical ailments (symptoms and diseases in various systems and parts of the body) and mental disorders (anxiety, depression, suicidal ideation), all affecting lifestyles, behaviour and personal and social relationships, both in affected individuals and their families. The increase in the use of medical drugs and health services serves as a final corollary to the imbalances on the affected people's health. Individuals and the Spanish society demand public health policy measures to mitigate the effects on health and the recovery of their confidence in the banking and political system


Asunto(s)
Humanos , Fraude/psicología , Trastornos Mentales/epidemiología , Quiebra Bancaria , Calidad de Vida/psicología , Riesgo Financiero/psicología , Recesión Económica/tendencias
5.
Gac Sanit ; 34(3): 268-275, 2020.
Artículo en Español | MEDLINE | ID: mdl-31964535

RESUMEN

During the economic crisis, developed countries have experienced financial fraud, with effects on the physical and mental health of the people affected, and on social domains. Based on the theoretical framework in literature reviews and in quantitative studies, this paper aims to obtain evidence on the effects of financial fraud on health and on the family and social environments of those affected. An intentional sample of 32 people affected by abusive and multi-currency mortgages, preferred and swap stock in Madrid was approached. In-depth interviews were conducted, and the resulting data was analysed using content analysis. Fraud-affected individuals had conditions of age, sex, educational level and occupations that possibly allowed them to accumulate economic resources throughout the course of their lives and, predictably in many cases, to take out fraudulent financial products, based on trust in the financial institutions. Financial fraud has led to the emergence of various processes of anomia and adverse health effects. The consequences on health were physical ailments (symptoms and diseases in various systems and parts of the body) and mental disorders (anxiety, depression, suicidal ideation), all affecting lifestyles, behaviour and personal and social relationships, both in affected individuals and their families. The increase in the use of medical drugs and health services serves as a final corollary to the imbalances on the affected people's health. Individuals and the Spanish society demand public health policy measures to mitigate the effects on health and the recovery of their confidence in the banking and political system.


Asunto(s)
Cuenta Bancaria , Recesión Económica , Fraude/economía , Adulto , Cuenta Bancaria/economía , Quiebra Bancaria/economía , Utilización de Medicamentos/economía , Familia , Femenino , Fraude/estadística & datos numéricos , Política de Salud/economía , Estado de Salud , Humanos , Renta , Entrevistas como Asunto , Estilo de Vida , Masculino , Trastornos Mentales/economía , Trastornos Mentales/etiología , Persona de Mediana Edad , Aceptación de la Atención de Salud , Investigación Cualitativa , Interacción Social , Factores Socioeconómicos , España
6.
Rehabil Psychol ; 65(1): 31-44, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31647269

RESUMEN

PURPOSE/OBJECTIVE: The aim of this study was to develop and test the psychometric properties of the Coping With Disability Difficulties Scale (CDDS), a scale to measure the coping strategies used by people with disabilities to face the disability-related difficulties (caused by both disability itself and by stigma) they encounter in their daily lives. METHOD/DESIGN: An initial pool of 110 items was developed based on previous literature and the results of a qualitative study using semistructured interviews. The psychometric characteristics of the CDDS were examined in 3 samples of people with disabilities (each of which included participants with physical, visual, and hearing impairments; total N = 590). RESULTS: A final scale of 17 items was obtained. The factor structure of the CDDS was tested and replicated with an adequate fit (root mean square error of approximation [RMSEA] = 0.056; goodness-of-fit index [GFI] = 0.98; comparative fit index [CFI] = 0.98) using confirmatory factor analysis. The internal consistency of the 4 factors (positive thinking, social sensitization and support, adaptation, and avoidance) was adequate to excellent (with alphas ranging from .68 to .86). CONCLUSIONS/IMPLICATIONS: To the authors' knowledge, this is the first coping scale that is specifically designed for people with disabilities, and it can be highly useful for both research and applied purposes. (PsycINFO Database Record (c) 2020 APA, all rights reserved).


Asunto(s)
Adaptación Psicológica , Personas con Discapacidad/psicología , Encuestas y Cuestionarios/estadística & datos numéricos , Adulto , Personas con Discapacidad/estadística & datos numéricos , Estudios de Evaluación como Asunto , Análisis Factorial , Femenino , Humanos , Entrevistas como Asunto , Masculino , Persona de Mediana Edad , Proyectos Piloto , Psicometría , Calidad de Vida/psicología , Reproducibilidad de los Resultados , Resiliencia Psicológica , Autoimagen , Apoyo Social
7.
Rehabil Psychol ; 64(2): 212-220, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-30985181

RESUMEN

OBJECTIVE: To analyze the consequences for self-esteem of perceived discrimination against people with physical disabilities, as individuals and as a group. METHOD: A structural model based on the psychosocial literature was tested in a sample of 288 Spanish participants with different degrees of physical disability. This model predicted that personal perceived discrimination would be associated with the internalization of stigma that, in turn, would be negatively associated with the self-esteem of people with physical disabilities. On the other hand, group perceived discrimination, was predicted to enhance group identification and promote intention to contribute to collective action and hence have a beneficial effect on the self-esteem of people with physical disabilities. RESULTS: The model provided a good fit to the data. The relationship between personal discrimination and the self-esteem of people with physical disabilities was completely mediated by internalized stigma. The model also showed that group perceived discrimination had only an indirect effect on self-esteem. CONCLUSION: This research makes two main contributions. From a theoretical perspective we found that perceived personal and group discrimination influence self-esteem through different paths. From an applied point of view, our results may contribute to the design of interventions to enhance the quality of life of people with physical disabilities. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Asunto(s)
Personas con Discapacidad/psicología , Personas con Discapacidad/estadística & datos numéricos , Prejuicio/psicología , Prejuicio/estadística & datos numéricos , Autoimagen , Identificación Social , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Calidad de Vida/psicología , España , Adulto Joven
8.
Span J Psychol ; 21: E12, 2018 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-29759090

RESUMEN

The purpose of this study is to assess the discourse of people with disabilities regarding their perception of discrimination and stigma. Semi-structured interviews were conducted with ten adults with physical disabilities, ten with hearing impairments and seven with visual impairments. The agreement between the coders showed an excellent reliability for all three groups, with kappa coefficients between .82 and .96. Differences were assessed between the three groups regarding the types of discrimination they experienced and their most frequent emotional responses. People with physical disabilities mainly reported being stared at, undervalued, and subtly discriminated at work, whereas people with hearing impairments mainly reported encountering barriers in leisure activities, and people with visual impairments spoke of a lack of equal opportunities, mockery and/or bullying, and overprotection. Regarding their emotional reactions, people with physical disabilities mainly reported feeling anxious and depressed, whereas people with hearing impairments reported feeling helpless, and people with visual impairments reported feeling anger and self-pity. Findings are relevant to guide future research and interventions on the stigma of disability.


Asunto(s)
Personas con Discapacidad/psicología , Emociones , Empleo/psicología , Actividades Recreativas/psicología , Prejuicio , Estigma Social , Adulto , Femenino , Humanos , Relaciones Interpersonales , Masculino , Persona de Mediana Edad , Personas con Deficiencia Auditiva/psicología , Personas con Daño Visual/psicología
11.
Span. j. psychol ; 21: e12.1-e12.11, 2018. tab, graf
Artículo en Inglés | IBECS | ID: ibc-189097

RESUMEN

The purpose of this study is to assess the discourse of people with disabilities regarding their perception of discrimination and stigma. Semi-structured interviews were conducted with ten adults with physical disabilities, ten with hearing impairments and seven with visual impairments. The agreement between the coders showed an excellent reliability for all three groups, with kappa coefficients between .82 and .96. Differences were assessed between the three groups regarding the types of discrimination they experienced and their most frequent emotional responses. People with physical disabilities mainly reported being stared at, undervalued, and subtly discriminated at work, whereas people with hearing impairments mainly reported encountering barriers in leisure activities, and people with visual impairments spoke of a lack of equal opportunities, mockery and/or bullying, and overprotection. Regarding their emotional reactions, people with physical disabilities mainly reported feeling anxious and depressed, whereas people with hearing impairments reported feeling helpless, and people with visual impairments reported feeling anger and self-pity. Findings are relevant to guide future research and interventions on the stigma of disability


No disponible


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Personas con Discapacidad/psicología , Emociones , Empleo/psicología , Actividades Recreativas/psicología , Prejuicio , Estigma Social , Relaciones Interpersonales , Personas con Deficiencia Auditiva/psicología , Personas con Daño Visual/psicología
12.
Psicothema (Oviedo) ; 29(4): 475-481, nov. 2017. tab, graf
Artículo en Inglés | IBECS | ID: ibc-167754

RESUMEN

Background: The situation of lesbians and gay men (LGs) in Spain has improved significantly in recent decades. However, Spanish society still exhibits prejudice and discrimination. The current study pursues three main goals: 1) to analyse the extent to which LGs perceive blatant and subtle discrimination, 2) to explore the relationship between perceived discrimination and LGs’ psychological and subjective well-being, and 3) to analyse the possible mediational role of social support in reducing the negative influence of perceived discrimination on well-being. Method: The sample comprised 237 lesbians and 232 gay men. Results: The results show higher perceived subtle than blatant discrimination, and that subtle discrimination affects LGs’ well-being more negatively than blatant discrimination. Results show that social support helps to alleviate the negative effects of discrimination on well-being. Conclusions: These results are important and may contribute to the design of interventions to improve the well-being of lesbians and gay men (AU)


Antecedentes: la situación de las personas lesbianas y gais (LG) en España ha mejorado mucho en las últimas décadas. Sin embargo, el prejuicio y la discriminación todavía están presentes en la sociedad española. El presente estudio persigue tres objetivos principales: 1) analizar hasta qué punto las personas LG perciben la existencia de discriminación manifiesta y sutil; 2) explorar la relación existente entre la discriminación percibida y el bienestar psicológico y subjetivo de las personas LG; y 3) analizar el papel mediador que el apoyo social puede jugar a la hora de reducir la influencia negativa de la discriminación percibida en el bienestar. Método: la muestra incluía 237 mujeres lesbianas y 232 hombres gais. Resultados: los resultados muestran que la discriminación sutil percibida es mayor que la manifiesta y que además dicha discriminación sutil, comparada con la manifiesta, tiene efectos más negativos en el bienestar de las personas LG. Los resultados muestran que el apoyo social contribuye a aliviar los efectos negativos de la discriminación en el bienestar. Conclusiones: estos resultados son relevantes y pueden contribuir a diseñar intervenciones para mejorar el bienestar de las personas LG (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Discriminación Social , Minorías Sexuales y de Género/psicología , Homosexualidad/psicología , Satisfacción Personal , Apoyo Social
13.
Psicothema ; 29(4): 475-481, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-29048306

RESUMEN

BACKGROUND: The situation of lesbians and gay men (LGs) in Spain has improved significantly in recent decades. However, Spanish society still exhibits prejudice and discrimination. The current study pursues three main goals: 1) to analyse the extent to which LGs perceive blatant and subtle discrimination, 2) to explore the relationship between perceived discrimination and LGs’ psychological and subjective well-being, and 3) to analyse the possible mediational role of social support in reducing the negative influence of perceived discrimination on well-being. METHOD: The sample comprised 237 lesbians and 232 gay men. RESULTS: The results show higher perceived subtle than blatant discrimination, and that subtle discrimination affects LGs’ well-being more negatively than blatant discrimination. Results show that social support helps to alleviate the negative effects of discrimination on well-being. CONCLUSIONS: These results are important and may contribute to the design of interventions to improve the well-being of lesbians and gay men.


Asunto(s)
Homosexualidad Femenina/psicología , Homosexualidad Masculina/psicología , Prejuicio , Percepción Social , Apoyo Social , Adolescente , Adulto , Anciano , Femenino , Homofobia/psicología , Humanos , Masculino , Persona de Mediana Edad , España , Adulto Joven
14.
Psychol Health Med ; 22(4): 406-414, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-26983584

RESUMEN

The goal of this study is to test a model in which personal discrimination predicts internalized stigma, while group discrimination predicts a greater willingness to engage in collective action. Internalized stigma and collective action, in turn, are associated to positive and negative affect. A cross-sectional study with 213 people with mental illness was conducted. The model was tested using path analysis. Although the data supported the model, its fit was not sufficiently good. A respecified model, in which a direct path from collective action to internalized stigma was added, showed a good fit. Personal and group discrimination appear to impact subjective well-being through two different paths: the internalization of stigma and collective action intentions, respectively. These two paths, however, are not completely independent, as collective action predicts a lower internalization of stigma. Thus, collective action appears as an important tool to reduce internalized stigma and improve subjective well-being. Future interventions to reduce the impact of stigma should fight the internalization of stigma and promote collective action are suggested.


Asunto(s)
Procesos de Grupo , Enfermos Mentales/psicología , Prejuicio/psicología , Autoimagen , Estigma Social , Adulto , Anciano , Estudios Transversales , Femenino , Humanos , Intención , Masculino , Persona de Mediana Edad , Modelos Estadísticos , Adulto Joven
15.
Artículo en Inglés | MEDLINE | ID: mdl-23644170

RESUMEN

OBJECTIVE: The present study analyzes the existing relationship between three variables related to social rejection (perception of overt and subtle discrimination and stigma consciousness) and the psychological and subjective well-being among people with schizophrenia. Likewise, we will analyze the relationship between two possible strategies to cope with stigma (active coping and avoidant coping) and well-being. METHOD: A cross-sectional study was conducted in a sample of 50 people with schizophrenia recruited from the social care network for people with mental illness in the Community of Madrid. RESULTS: Results show, as expected, the existence of a negative association between the variables related to social rejection and psychological and subjective well-being. It was also found that avoidant coping is negatively related to well-being, while active coping is positively related, although in the latter case relations do not reach significance. CONCLUSIONS: In view of the implementation of interventions to improve the well-being of people with schizophrenia, our results suggest implementing strategies to reduce the perception of discrimination (especially subtle or indirect discrimination) and encouraging the use of active strategies to cope with stigma as opposed to avoidant-coping strategies.


Asunto(s)
Adaptación Psicológica/fisiología , Esquizofrenia , Psicología del Esquizofrénico , Ajuste Social , Estigma Social , Estudios Transversales , Femenino , Humanos , Masculino , Prejuicio , Distancia Psicológica , Autoimagen
16.
Span J Psychol ; 18: E75, 2015 Oct 13.
Artículo en Inglés | MEDLINE | ID: mdl-26459044

RESUMEN

The present study examines the relationships between perceived discrimination, internalized stigma, and well-being in a sample of people with mental illness. We conducted a cross-sectional study with 213 outpatients from the Spanish public network of social care. Perceived discrimination was positively and significantly correlated with internalized stigma (p < .01 for all measures of perceived discrimination). Blatant individual discrimination, subtle individual discrimination, and internalized stigma were negatively correlated with life satisfaction, affect balance, and psychological well-being (p < .01 for all cases, except for blatant individual discrimination and affect balance, for which is p < .05). Regression and mediation analyses indicate that subtle individual discrimination is the kind of discrimination most negatively associated to the well-being measures (life satisfaction: B = -.18, p < .10; affect balance: B = -.19, p < .10; psychological well-being: B = -.21, p < .05), and that this association is mediated by internalized stigma. Future research should confirm these findings in a longitudinal or experimental model. In light of our findings, we suggest the development and implementation of intervention programs that target subtle discrimination, and point at the importance of implementing programs to reduce internalized stigma.


Asunto(s)
Ajuste Emocional , Trastornos Mentales/psicología , Prejuicio , Estereotipo , Adulto , Afecto , Estudios Transversales , Femenino , Humanos , Masculino , Satisfacción Personal , Pruebas Psicológicas , España , Encuestas y Cuestionarios
17.
Psychiatry Res ; 228(3): 325-31, 2015 Aug 30.
Artículo en Inglés | MEDLINE | ID: mdl-26162660

RESUMEN

This study examines the relationships between internalized stigma, psychological well-being, and subjective well-being in a sample of people with mental illness. We conducted a cross-sectional study with 213 outpatients from the Spanish public social care network. The results showed that (a) internalized stigma was significantly negatively correlated with psychological well-being and subjective well-being (affect balance and life satisfaction) (all correlations are significant with at least p<0.05; most with p<0.001), (b) the two types of well-being were significantly positively correlated and regressions models were significant and (all correlations are at least p<0.01, and regression models are also significant), (c) the effect of internalized stigma on affect balance and life satisfaction was mediated by psychological well-being. The component of internalized stigma most consistently associated with both types of well-being was alienation (life satisfaction: B=-0.35, p=0.001; affect balance: B=-0.38, p=0.001). These findings should be confirmed in future longitudinal or experimental research. On the basis of these results we recommend that interventions to combat self-stigma aim to reduce feelings of alienation and improve self-acceptance and other aspects of positive psychological functioning.


Asunto(s)
Trastornos Mentales/epidemiología , Trastornos Mentales/psicología , Autoimagen , Estigma Social , Adulto , Anciano , Redes Comunitarias , Estudios Transversales , Mecanismos de Defensa , Emociones , Femenino , Humanos , Masculino , Trastornos Mentales/diagnóstico , Persona de Mediana Edad , España/epidemiología , Adulto Joven
18.
Span. j. psychol ; 18: e75.1-e75.9, 2015. tab, ilus
Artículo en Inglés | IBECS | ID: ibc-142789

RESUMEN

The present study examines the relationships between perceived discrimination, internalized stigma, and well-being in a sample of people with mental illness. We conducted a cross-sectional study with 213 outpatients from the Spanish public network of social care. Perceived discrimination was positively and significantly correlated with internalized stigma (p < .01 for all measures of perceived discrimination). Blatant individual discrimination, subtle individual discrimination, and internalized stigma were negatively correlated with life satisfaction, affect balance, and psychological well-being (p < .01 for all cases, except for blatant individual discrimination and affect balance, for which is p < .05). Regression and mediation analyses indicate that subtle individual discrimination is the kind of discrimination most negatively associated to the well-being measures (life satisfaction: B = -.18, p < .10; affect balance: B = -.19, p < .10; psychological well-being: B = -.21, p < .05), and that this association is mediated by internalized stigma. Future research should confirm these findings in a longitudinal or experimental model. In light of our findings, we suggest the development and implementation of intervention programs that target subtle discrimination, and point at the importance of implementing programs to reduce internalized stigma (AU)


No disponible


Asunto(s)
Femenino , Humanos , Masculino , Discriminación en Psicología , Discriminación Social/psicología , Discriminación Social/estadística & datos numéricos , Estigma Social , Salud Mental/normas , Salud Mental/tendencias , Pruebas Psicológicas/estadística & datos numéricos , Escalas de Valoración Psiquiátrica/estadística & datos numéricos , Encuestas y Cuestionarios , Satisfacción Personal , Carencia Psicosocial , Apoyo Social
19.
PLoS One ; 9(5): e96930, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24841633

RESUMEN

BACKGROUND: In case of outbreak of rash illness in remote areas, clinically discriminating monkeypox (MPX) from severe form of chickenpox and from smallpox remains a concern for first responders. OBJECTIVE: The goal of the study was therefore to use MPX and chickenpox outbreaks in Democratic Republic of Congo (DRC) as a test case for establishing a rapid and specific diagnosis in affected remote areas. METHODS: In 2008 and 2009, successive outbreaks of presumed MPX skin rash were reported in Bena Tshiadi, Yangala and Ndesha healthcare districts of the West Kasai province (DRC). Specimens consisting of liquid vesicle dried on filter papers or crusted scabs from healing patients were sampled by first responders. A field analytical facility was deployed nearby in order to carry out a real-time PCR (qPCR) assay using genus consensus primers, consensus orthopoxvirus (OPV) and smallpox-specific probes spanning over the 14 kD fusion protein encoding gene. A PCR-restriction fragment length polymorphism was used on-site as backup method to confirm the presence of monkeypox virus (MPXV) in samples. To complete the differential diagnosis of skin rash, chickenpox was tested in parallel using a commercial qPCR assay. In a post-deployment step, a MPXV-specific pyrosequencing was carried out on all biotinylated amplicons generated on-site in order to confirm the on-site results. RESULTS: Whereas MPXV proved to be the agent causing the rash illness outbreak in the Bena Tshiadi, VZV was the causative agent of the disease in Yangala and Ndesha districts. In addition, each on-site result was later confirmed by MPXV-specific pyrosequencing analysis without any discrepancy. CONCLUSION: This experience of rapid on-site dual use DNA-based differential diagnosis of rash illnesses demonstrates the potential of combining tests specifically identifying bioterrorism agents and agents causing natural outbreaks. This opens the way to rapid on-site DNA-based identification of a broad spectrum of causative agents in remote areas.


Asunto(s)
Exantema/virología , Herpesvirus Humano 3/genética , Monkeypox virus/genética , Orthopoxvirus/genética , Varicela/virología , ADN Viral/genética , Herpesvirus Humano 3/patogenicidad , Humanos , Monkeypox virus/patogenicidad , Orthopoxvirus/patogenicidad , Reacción en Cadena de la Polimerasa/métodos , Virus de la Viruela/genética , Virus de la Viruela/patogenicidad
20.
Eur J Immunol ; 42(11): 3038-48, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22930439

RESUMEN

We report the results of the Theravac-01 phase I trial, which was conducted to evaluate the safety and immunogenicity of a poxvirus-based vector, NYVAC, expressing Gag, Pol, Nef, and Env from an HIV clade B isolate. NYVAC-B vaccine was injected intra-muscularly into ten HIV-infected patients successfully treated with antiretroviral therapy, twice on day 0 and again at week 4. Safety and immunogenicity were monitored for 48 weeks. HIV-specific T-cell responses following immunization were quantitatively analyzed using an IFN-γ ELISPOT assay and qualitatively characterized for their functional profile (including multiple cytokines secretion plus cytotoxic and proliferation capacity) by polychromatic flow cytometry. Our results indicate that the NYVAC-B vaccine is safe and highly immunogenic, as indicated by increased HIV-specific T-cell responses in virtually all vaccinees. Interestingly, both an expansion of preexisting T-cell responses, and the appearance of newly detected HIV-specific CD4(+) and CD8(+) T-cell responses were observed. Furthermore, immunization mostly induced an increase in Gag-specific T-cell responses. In conclusion, NYVAC-B immunization induces broad, vigorous, and polyfunctional HIV-specific T-cell responses, suggesting that poxvirus-based vaccine regimens may be instrumental in the therapeutic HIV vaccine field.


Asunto(s)
Linfocitos T CD4-Positivos/inmunología , Linfocitos T CD8-positivos/inmunología , Infecciones por VIH/inmunología , Infecciones por VIH/terapia , VIH/inmunología , Vacunas Virales/administración & dosificación , Adulto , Fármacos Anti-VIH/uso terapéutico , Recuento de Linfocito CD4 , Linfocitos T CD4-Positivos/virología , Linfocitos T CD8-positivos/virología , Procesos de Crecimiento Celular/efectos de los fármacos , Procesos de Crecimiento Celular/inmunología , Ensayo de Inmunoadsorción Enzimática , Citometría de Flujo , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/virología , Humanos , Interferón gamma/sangre , Interferón gamma/inmunología , Masculino , Persona de Mediana Edad , ARN Viral/sangre , Suiza , Vacunas Virales/inmunología
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