Central conducting lymphatic anomaly: from bench to bedside.

Central conducting lymphatic anomaly (CCLA) is a complex lymphatic anomaly characterized by abnormalities of the central lymphatics and may present with nonimmune fetal hydrops, chylothorax, chylous ascites, or lymphedema. CCLA has historically been difficult to diagnose and treat; however, recent advances in imaging, such as dynamic contrast magnetic resonance lymphangiography, and in genomics, such as deep sequencing and utilization of cell-free DNA, have improved diagnosis and refined both genotype and phenotype. Furthermore, in vitro and in vivo models have confirmed genetic causes of CCLA, defined the underlying pathogenesis, and facilitated personalized medicine to improve outcomes. Basic, translational, and clinical science are essential for a bedside-to-bench and back approach for CCLA.

Updates in Genetic Testing for Head and Neck Vascular Anomalies.

Vascular anomalies include benign or malignant tumors or benign malformations of the arteries, veins, capillaries, or lymphatic vasculature. The genetic etiology of the lesion is essential to define the lesion and can help navigate choice of therapy. . In the United States, about 1.2% of the population has a vascular anomaly, which may be underestimating the true prevalence as genetic testing for these conditions continues to evolve.

Latin American perceptions of fear and exaggeration transmitted by the media with regard to COVID-19: frequency and association with severe mental pathologies.

Introduction: The COVID-19 pandemic contributed to the spread of abundant misinformation by the media, which caused fear and concern. Objective: To determine the association between the pathologies of the mental sphere and the perceptions of fear and exaggeration transmitted by the media with respect to COVID-19 in Latin America. Methodology: The present study has an analytical cross-sectional design that is based on a validated survey to measure fear and exaggeration transmitted by the media and other sources (Cronbach's α: 0.90). We surveyed more than 6,000 people, originally from 12 Latin American countries, who associated this perceived exaggeration with stress, depression, and anxiety (measured through DASS-21, Cronbach's α: 0.96). Results: Social networks (40%) or television (34%) were perceived as the sources that exaggerate the magnitude of the events. In addition, television (35%) and social networks (28%) were perceived as the sources that generate much fear. On the contrary, physicians and health personnel are the sources that exaggerated less (10%) or provoked less fear (14%). Through a multivariate model, we found a higher level of global perception that was associated with whether the participant was older (p = 0.002), had severe or more serious anxiety (p = 0.033), or had stress (p = 0,037). However, in comparison with Peru (the most affected country), there was a lower level of perception in Chile (p < 0.001), Paraguay (p = 0.001), Mexico (p < 0.001), Ecuador (p = 0.001), and Costa Rica (p = 0.042). All of them were adjusted for gender and for those having severe or major depression. Conclusion: There exists an association between some mental pathologies and the perception that the media does not provide moderate information.

Prevalence and Associated Factors of Depression, Anxiety, and Stress in University Students in Paraguay during the COVID-19 Pandemic.

We aimed to determine the prevalence of depression, anxiety, and stress in university students in Paraguay during the COVID-19 pandemic. A cross-sectional study was conducted among 293 students from four universities in Paraguay in 2021. The DASS-21 mental health scale was used to measure the outcomes (depression, anxiety, and stress) and evaluate their association with socio-educational variables. A total of 77.1% of the participants were women and 136 (46.4%) were between 21 and 25 years old. The prevalence of depression, anxiety, and stress was 74.7%, 87.4%, and 57%, respectively. We found that being a woman and studying at a public university was positively associated with depression, anxiety, and stress. Receiving COVID-19 training increases the prevalence of mental health problems. In conclusion, high levels of anxiety, depression, and stress were found in university students during the COVID-19 pandemic. Being a woman, studying at a public university, and receiving training on COVID-19 were factors associated with a higher prevalence of presenting all the mental health problems evaluated. Furthermore, students aged 31 and over had a higher prevalence of depression and stress.

Basic COVID-19 knowledge according to education level and country of residence: Analysis of twelve countries in Latin America.

Introduction: Knowing a disease is crucial for being able to fight it, especially in a region in which COVID-19 caused so many deaths, such as Latin America. Objective: To determine the association between basic knowledge of COVID-19 and education level according to country of residence in Latin America. Methodology: This is an analytical cross-sectional study. Basic level of knowledge was measured through nine close-ended questions (scale validated in Peru). The score obtained was analyzed through performing a crosstab vs. gender, age, education level, and country of residence. Results: Of a total of 9,222 respondents, almost all of them knew the common symptoms (99%), modes of transmission (93%), and knew how to recognize which was not a specific symptom (93%). Through the multivariate model, we found that there was no association with gender (p = 0.716) or age (p = 0.059), in comparison with those who had primary or a lower education level. All the other higher education levels had statistically significant scores (all p-values p < 0.001). When comparing knowledge according to countries, and using Peru as reference for comparison, Chile, Paraguay, Mexico, Bolivia, Panama, Ecuador, Costa Rica, and Colombia had a better level of knowledge (all p-values < 0.001); however, only El Salvador had a lower level (p < 0.001). Discussion: There was lack of knowledge of some topics, difference according to academic degree and country. As Peru was one of countries that obtained the lowest level of knowledge, it could have influenced the fact that it was the most affected country in the world.

Impacto de la virtualización de la educación médica en el rendimiento académico en 2020 / Impact of virtualization of medical education on academic performance in 2020

RESUMEN Introducción: La declaración de la pandemia en marzo del 2020 ha obligado a las universidades del mundo a adaptarse a una nueva metodología basada totalmente en la virtualidad. Objetivo: Identificar el impacto generado por la virtualización de la educación en el rendimiento académico de estudiantes de medicina en el año 2020. Métodos: Estudio observacional, descriptivo de corte transversal. Los datos del rendimiento académico de los estudiantes del cuarto y quinto curso de los años 2019 y 2020 fueron obtenidos de manera anónima de la base de datos de la universidad. La información recolectada fue ingresada en Excel y analizada en EpiInfo; las variables cualitativas se expresaron como frecuencia absoluta y relativa, las continuas como media y desviación estándar. Resultados: En el cuarto año en cuanto a la asignatura farmacología, el porcentaje promedio durante el año 2020 fue del 80 %, en semiología quirúrgica 87,3 % y en semiología médica 87,9 %. En el quinto año en cuanto a la asignatura ginecología y obstetricia el porcentaje promedio durante el año 2020 fue del 92 %, en pediatría 74,7 % y en clínica médica 89,6 %. Conclusión: Hay importante impacto generado por la virtualización de la educación en el rendimiento académico de estudiantes de medicina en el año 2020, en comparación con el año 2019.

ABSTRACT Introduction: The declaration of the pandemic in March 2020 has forced the world's universities to adapt to a new methodology based entirely on virtuality. Objective: To identify the impact generated by the virtualization of education on the academic performance of medical students in 2020. Methods: An observational, descriptive study with a cross-sectional. The data of the academic performance of the students of the fourth and fifth years of the years 2019 and 2020 were obtained anonymously from the university's database. The data were entered in Excel and analyzed by EpiInfo; qualitative variables were expressed as absolute and relative frequency, continuous ones as mean and standard deviation. The chi square test was used at a significance level of 0,05 to establish associations between variables. Results: In the fourth year regarding the pharmacology subject, the average percentage during 2020 was 80 %, in surgical semiology 87.3 % and in medical semiology 87.9 %. In the fifth year in terms of gynecology and obstetrics, the average percentage during 2020 was 92 %, in pediatrics 74.7 % and in medical clinic 89.6 %. Conclusion: There was a significant impact generated by the virtualization of education on the academic performance of medical students in 2020 compared to 2019.