RESUMEN
Background: In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is the commonest therapeutic intervention provided to these patients but it is unclear how much oxygen should be administered for the best clinical outcomes. Methods: The UK-ROX trial will evaluate the clinical and cost-effectiveness of conservative oxygen therapy (the minimum oxygen concentration required to maintain an oxygen saturation of 90% ± 2%) versus usual oxygen therapy in critically ill adults receiving supplemental oxygen when invasively mechanically ventilated in ICUs in England, Wales and Northern Ireland. The trial will recruit 16,500 patients from approximately 100 UK adult ICUs. Using a deferred consent model, enrolled participants will be randomly allocated (1:1) to conservative or usual oxygen therapy until ICU discharge or 90 days after randomisation. Objectives: The primary clinical outcome is all cause mortality at 90 days following randomisation. Discussion: The UK-ROX trial has received ethical approval from the South Central - Oxford C Research Ethics Committee (Reference: 20/SC/0423) and the Confidentiality Advisory Group (Reference: 22/CAG/0154). The trial commenced in May 2021 and, at the time of publication, 95 sites had opened to recruitment.
RESUMEN
Delirium, and its importance, is briefly discussed to contextualise the intricate story of one patient's experience of the condition. This recounting of the main episodes of delirium shows how its nature and severity changed with time and location, from ICU to the surgical ward. Reflection on these experiences provides insights and conclusions for consideration by the medical profession. Discussion of the nature of delirium, and the sort of interventions that helped, or might be provided, for recovery from, or reduction of, the condition are considered. Thought is given to what might be done to aid recovery and reduce severity. Some suggestions are made as to what education might be provided and the research required to better detect the condition and understand its nature and prevention.
