[Correlation of microangiographic and thermographic signs in sarcoma 45]. / Korreliatsiia mikroangiograficheskikh i termograficheskikh priznakov pri sarkome-45.

Thermographic and microangiographic studies on transplantable sarcoma 45 in subcutaneous and intramuscular implantation of tumor cells showed the appearance of "hot" and "cold" foci in the zone of tumor development. In subcutaneous implantation of sarcoma 45 "hot" foci were observed in the 1st week only, then the focal temperature was decreased and a tumor zone acquired the properties of a "cold" focus. In intramuscular tumor implantation the symptom of a "hot" focus was noted during 3 weeks. Angiography showed that the state of the vascular network of a tumor, rearrangement of microcirculation in external and central tumor zones were in some correlation to a site of tumor inoculation. Tumors of the subcutaneous fat were characterized by rapid avascularization with the formation of the "cold" focus symptom. A high degree of tumor vascularization corresponded to "hot" zones, hypovascular tumors--to "cold" zones. "Hot" zones could develop at the expense of arteriovenous anastomoses discharging hot arterial blood into the venous tumor bed passing the capillaries. Direct correlation was established between the state of blood circulation and a thermographic picture.

[Study of animals with transplanted tumors]. / Issledovanie zhivotnykh s perevivnoi opukhol'iu.

A formula of temperature homeostasis of the body during inoculated tumor development was described. The basic data were temperature parameters of tumor S-45 inoculated to 180 rats subcutaneously and intramuscularly. Thermography was used as a method of investigation. An analysis of the results obtained led to a conclusion of a principal difference in the nature of heat processes in the body with tumors at different depths. In addition to it, the heat status of a tumor reflected the state of the vascular system making it possible to assess a necessary degree and nature of therapeutic exposure. Taking into account two periods of a heat status of the body one could choose the most effective therapeutic method during tumor development. The above material formed the basis for producing a heat model of tumor in order to improve methods of cancer diagnosis and therapy.

[Characteristics of the growth rate of the transplantable sarcoma 45]. / Kharakteristika skorosti rosta perevivnoi sarkomy 45.

The growth dynamics of the experimental tumour was analyzed in 180 mongrel rats with sarcoma-45 inoculated intramuscularly and subcutaneously. One of the approaches to the calculation of doubling time is estimated. It is suggested that the changes of the C-45 tumour size may be described according to the function V = A exp(T/B)--C.