[Pregnancy and experimental autoimmune encephalomyelitis induced in different terms of gestation period]. / Beremennost' i indutsirovannyi na raznykh srokakh gestatsionnogo perioda éksperimental'nyi autoimmunnyi éntsefalomielit.

Objective. To investigate the features of the clinical course of experimental demyelinating pathology as a model of multiple sclerosis in rats in different trimesters of pregnancy. Material and methods. We used 48 nonlinear white female rats to study an effect of pregnancy on susceptibility to and clinical features of demyelinating pathology. Results and сonclusion. Severity of disease was shown to be a priority risk factor of pregnancy, which is realized depending on the period of gestation. An increase of representation and aggravation of the reproductive pathology during modeling of multiple sclerosis in II trimester indicates a risk of relapse in the late periods of reproduction cycle, derogates the idea about total retentive influence of pregnancy on the development of demyelinating events.

Potentiated antibodies to mu-opiate receptors: effect on integrative activity of the brain.

The effect of homeopathically potentiated antibodies to mu-receptors (10(-100) wt %) on integrative activity of rat brain was studied using the models of self-stimulation of the lateral hypothalamus and convulsions produced by electric current. Electric current was delivered through electrodes implanted into the ventromedial hypothalamus. Single treatment with potentiated antibodies to mu-receptors increased the rate of self-stimulation and decreased the threshold of convulsive seizures. Administration of these antibodies for 7 days led to further activation of the positive reinforcement system and decrease in seizure thresholds. Distilled water did not change the rate of self-stimulation and seizure threshold.

Effect of potentiated antibodies to morphine on behavioral reactions in rats with morphine dependence.

We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.

Morphine and its potentiated form: effects on pain sensitivity in rats.

We studied the effects of morphine and its potentiated form on nociceptive thresholds in rats with the morphine withdrawal syndrome. Repeated combination (bipathic) treatment with morphine and its potentiated form increased nociceptive threshold and, therefore, activated the nociceptive system in the brain.

Neurotropic and neurospecific substances and their antibodies: effects on conditioned activity of rats.

We compared the effects of neurotropic and neurospecific substances and their antibodies on conditioned activity of rats. Single treatment produced the positive effect on the latency and number of conditioned responses. Repeated treatment with test compounds in the same dose improved conditioned activity of animals.

Neurotropic compounds and their antibodies: effect on the brain system of positive emotional reinforcement.

We studied the effects of ethanol, morphine, S100 protein, and antibodies to morphine, S100 protein, and opiate -receptors in ultralow doses on self-stimulation of the lateral hypothalamus. The reaction underwent similar changes after single administration of test preparations. Tenfold treatment produced the stimulatory and stabilizing effect, which was related to ambivalent properties of preparations in ultralow doses. Tenfold administration of water did not produce changes in control animals.

Psychoactive compounds and their antibodies: effect on self-stimulation of the lateral hypothalamus in morphinized rats.

We studied the effect of morphine hydrochloride, brain-specific S100 protein, and antibodies to morphine, S100 protein, and opiate mu-receptors in ultralow doses on self-stimulation of the lateral hypothalamus in morphinized rats. This reaction in morphine-withdrawn rats underwent specific changes after single administration of test preparations. Repeated treatment with preparations in the same dose equalized emotional homeostasis. This effect was especially pronounced after treatment with antibodies to morphine, S100 protein, and opiate mu-receptors. Our findings should be taken into account in developing methods for non-narcotic substitutive therapy of patients with morphine dependence.

[The effect of interleukin-2 on experimental emotional hypertension]. / Vliianie interleikina-2 na émotsional'nuiu gipertenziiu v éksperimente.

The effect of human recombinant interleukin-2, one of the potent mediators of the immune system, on the course of emotional hypertension in non-linear white rats has been investigated. A significant and prolonged hypotensive action of a single injection of interleukin-2 in hypertensive rats has been revealed. The data obtained can be a new evidence of participation of immune system in the development of hypertension in experimental animals.

[Experimental analysis of the neurobiological basis of genetically determined alcohol addiction in the progeny]. / Eksperimental'nyi analiz neirobiologicheskikh osnov vlecheniia k alkogoliu u potomstva, otiagoshchennogo alkogolizmom.

Experiments on 45 nonlinear albino male rats were made to investigate bioelectrogenesis of the limbic-neocortical parts of the brain, function of the systems of positive and negative reinforcement and emotional behavior of the progeny of long alcoholized animals with successive growth of the extent of alcoholism aggravation. Their different initial characteristics were discovered in intact rats as regards parents' alcoholism and in alcoholism aggravated rats, determining different mechanisms and rates of the development of pathological ethanol addiction. The pathogenic influence of "familial" alcoholism lies in the formation in the progeny of the first and fourth generations of the model of alcohol addiction anticipation, whose pathological integration is realized on the basis of the beforehand prepared model which becomes quantitatively different as a result of genetic anomalies.