Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 13 de 13
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Data Brief ; 39: 107645, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34901352

RESUMEN

We present the raw data obtained from release rate at 1300°C of Xe and Kr implanted in UO2, related to [1]. We performed different sample preparation (polishing treatment) on polycrystalline and monocrystalline UO2. Ion implantation were performed at various fluences between 9.5 × 1010 to 5 × 1014 i/cm2 in UO2 samples. Release rate of Xe and Kr are obtained at 1300°C under vacuum from desorption experiments performed on the PIAGARA plateform at the CENBG (Centre d'Etudes Nucléaires de Bordeaux-Gradignan). Since we made a variety of samples depending on multiple parameters (sample type, sample preparation, ion implantation type and fluence), these data represent a serious amount of work that could be saved for the scientific community that might use them for other purposes such as burst modelling.

2.
Expert Opin Drug Saf ; 16(9): 989-995, 2017 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-28657366

RESUMEN

BACKGROUND: The link between isotretinoin, treatment of a severe form of acne, and psychiatric disorders remains controversial, as acne itself could explain the occurrence of psychiatric disorders. This study aims at assessing the disproportionality of psychiatric adverse events reported with isotretinoin in the French National PharmacoVigilance Database, compared with other systemic acne treatments and systemic retinoids. MATERIALS AND METHODS: Data were extracted from the French National PharmacoVigilance Database for systemic acne treatments, systemic retinoids and drugs used as comparators. Each report was subjected to double-blind analysis by two psychiatric experts. A disproportionality analysis was performed, calculating the number of psychiatric ADRs divided by the total number of notifications for each drug of interest. RESULTS: Concerning acne systemic treatments: all 71 reports of severe psychiatric disorders involved isotretinoin, the highest proportion of mild/moderate psychiatric adverse events was reported with isotretinoin (14.1%). Among systemic retinoids, the highest proportion of severe and mild/moderate psychiatric events occurred with isotretinoin and alitretinoin. CONCLUSION: Our study raises the hypothesis that psychiatric disorders associated with isotretinoin are related to a class effect of retinoids, as a signal emerges for alitretinoin. Complementary studies are necessary to estimate the risk and further determine at-risk populations.


Asunto(s)
Acné Vulgar/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéutico , Trastornos Mentales/inducido químicamente , Retinoides/uso terapéutico , Sistemas de Registro de Reacción Adversa a Medicamentos , Alitretinoína , Bases de Datos Factuales , Fármacos Dermatológicos/efectos adversos , Femenino , Francia , Humanos , Isotretinoína/efectos adversos , Isotretinoína/uso terapéutico , Masculino , Trastornos Mentales/epidemiología , Farmacovigilancia , Retinoides/efectos adversos , Riesgo , Índice de Severidad de la Enfermedad , Tretinoina/efectos adversos , Tretinoina/uso terapéutico , Adulto Joven
3.
Arch Pediatr ; 23(12S): 12S15-12S20, 2016 Dec.
Artículo en Francés | MEDLINE | ID: mdl-28231889

RESUMEN

In cystic fibrosis (CF), approximately 5-8% of the patients develop multilobular cirrhosis during the first decade of life. Annual screening (clinical examination, liver biochemistry, ultrasonography) is recommended in order to identify early signs of liver involvement, initiate ursodeoxycholic acid therapy and detect complications (portal hypertension and liver failure). Management should focus on nutrition and prevention of variceal bleeding. The gut may also be involved in children with CF. Gastroesophageal reflux is frequent, although often neglected and should be investigated by pH monitoring and impedancemetry, if available. Acute pancreatitis occurs in patients with persistent exocrine pancreatic activity. Intussusception, appendicular mucocele, distal intestinal occlusion syndrome, small bowel bacterial overgrowth and Clostridium difficile colitis should be considered in case of abdominal pain. Preventive nutritional support should be started as soon as possible after diagnosis of CF. Attainment of normal growth is one of the main goals and can be achieved with hypercaloric and salt supplemented food. Pancreatic enzyme replacement therapy should be started as soon as exocrine pancreatic insufficiency is confirmed and ingested immediately prior to meals with intake of fat-soluble vitamins. Curative nutritional interventions are more likely to be effective in the early stages of pulmonary disease. Feeding disorders, related to the physiopathology and the psychologic aspects of the disease are frequent. Repeated corporeal aggressions, associated with inappropriate medical and parental pressure, may increase the child's refusal of food. The multidisciplinary team should guide parents in order to avoid all intrusive feeding practices and promote pleasant mealtimes.


Asunto(s)
Fibrosis Quística/complicaciones , Fibrosis Quística/terapia , Enfermedades del Sistema Digestivo/etiología , Enfermedades del Sistema Digestivo/terapia , Trastornos de Ingestión y Alimentación en la Niñez/etiología , Trastornos de Ingestión y Alimentación en la Niñez/terapia , Cirrosis Hepática/etiología , Cirrosis Hepática/terapia , Niño , Preescolar , Terapia Combinada , Fibrosis Quística/diagnóstico , Enfermedades del Sistema Digestivo/diagnóstico , Diagnóstico Precoz , Intervención Médica Temprana , Trastornos de Ingestión y Alimentación en la Niñez/diagnóstico , Humanos , Lactante , Comunicación Interdisciplinaria , Colaboración Intersectorial , Cirrosis Hepática/diagnóstico , Relaciones Padres-Hijo
5.
Addict Behav ; 39(3): 562-5, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24315783

RESUMEN

OBJECTIVE: It is commonly accepted that pathological gambling results from the interaction of multiple risk factors. Among these, dopamine replacement therapy (DRT) prescribed for Parkinson disease can be cited. Another dopamine agonist, aripiprazole, could be a new risk factor. We decided to explore this potential adverse drug reaction (ADR). METHOD: Based on a cohort of 166 pathological gamblers starting treatment in our department, data of each of the 8 patients treated by aripiprazole at inclusion were analyzed. RESULTS: The patients involved were schizophrenic or bipolar, mostly young men with a history of addictive disorders and regular gambling prior to the prescription of aripiprazole. For each one of them, the causality of aripiprazole was considered, using an algorithm. The probability that pathological gambling is actually due to aripiprazole is "possible" in 7 cases out of 8, and "doubtful" in one. CONCLUSIONS: Adverse drug reactions were confronted with other already published case reports. Dopamine partial agonist mechanism of aripiprazole could explain the occurrence of pathological gambling.


Asunto(s)
Antipsicóticos/uso terapéutico , Trastorno Bipolar/tratamiento farmacológico , Agonistas de Dopamina/uso terapéutico , Juego de Azar , Piperazinas/uso terapéutico , Quinolonas/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Adulto , Aripiprazol , Trastorno Bipolar/complicaciones , Femenino , Juego de Azar/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Esquizofrenia/complicaciones , Adulto Joven
6.
J Clin Pharm Ther ; 34(5): 515-22, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19744007

RESUMEN

PURPOSE: To test bioequivalence of oral vitamin E formulations, water-soluble tocofersolan (test) and water-miscible (reference), in healthy adult volunteers, and their bioavailability in children with chronic cholestasis or cystic fibrosis. METHODS: In a two-way open randomized single dose cross-over design, 1200 IU were administered in 12 healthy volunteers and 100 IU/kg in 12 children with chronic cholestasis or cystic fibrosis. RESULTS: In healthy volunteers, formulations were not bioequivalent with a higher exposure to tocofersolan. In cholestatic children tocofersolan bioavailability was significantly higher than reference formulation (maximum plasma concentration: P = 0.008 and AUC: P = 0.0026). Bioavailability was not statistically different in cystic fibrosis. CONCLUSIONS: Oral tocofersolan was more bioavailable than the reference formulation in children with chronic cholestasis and similarly bioavailable in cystic fibrosis. Tocofersolan may represent an alternative to painful intramuscular vitamin E injections in chronic cholestasis, or to other oral formulations in cystic fibrosis.


Asunto(s)
Colestasis/metabolismo , Fibrosis Quística/metabolismo , Vitamina E/farmacocinética , Administración Oral , Adolescente , Adulto , Disponibilidad Biológica , Química Farmacéutica , Niño , Preescolar , Enfermedad Crónica , Estudios Cruzados , Humanos , Lactante , Persona de Mediana Edad , Vitamina E/administración & dosificación , Vitamina E/efectos adversos
7.
Eur Respir J ; 23(3): 430-4, 2004 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-15065834

RESUMEN

The use and complications of totally implantable vascular access devices (TIVADs) were examined during multiple courses of antibiotics in cystic fibrosis (CF) patients. This retrospective study involved 36 CF centres. Risk factors for removal and septicaemia were sought by survival analysis of censored data. Multivariate Cox models were constructed with removal or septicaemia as the event and the characteristics of TIVADs as explanatory variables. TIVADs (n = 452) were implanted in 315 patients. The mean functional time per device was 32 +/- 25 months. Long-term complications occurred with 188 devices (42%); they consisted mainly of occlusion (21%, requiring removal in 77%), infection (9.3%, requiring removal in 851%; septicaemia in 7.3%; rate 0.3 per 1,000 days, Candida in 66%), and vascular thrombosis (4.7%, removal in 58%). Multivariate survival analysis showed that removal, whatever the reason, was associated with polyurethane (versus silicone) and routine use of the device for blood sampling (versus never). No risk factors, including heparin lock, were identified for septicaemia or for removal for obstruction. Totally implantable venous access devices appear to be safe and reliable for long-term intermittent venous access. Although retrospective, this study suggests that the characteristics of the material and blood sampling are risk factors for removal.


Asunto(s)
Catéteres de Permanencia , Fibrosis Quística/terapia , Antibacterianos/administración & dosificación , Recolección de Muestras de Sangre , Catéteres de Permanencia/efectos adversos , Niño , Infección Focal/epidemiología , Estudios de Seguimiento , Humanos , Infusiones Intravenosas , Nutrición Parenteral , Modelos de Riesgos Proporcionales , Estudios Retrospectivos , Factores de Riesgo , Sepsis/epidemiología , Trombosis/epidemiología , Factores de Tiempo
8.
Pediatr Pulmonol ; 32(4): 288-92, 2001 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11568989

RESUMEN

Chronic infection by Pseudomonas aeruginosa (PA) in patients with cystic fibrosis (CF) is preceded by a period of colonization and acute infection. Early aggressive antibiotic treatment of initial colonisation may prevent or at least delay chronic pulmonary infection. We initiated treatment with a combination of IV beta-lactam tobramycin, followed by nebulized colistin when PA was first isolated from patients with CF. Subsequent serial PA isolates obtained from these colonized CF patients were characterized by means of molecular methods to determine whether they were genetically related to the initial strain. Initial colonization was eradicated in all 19 patients. All patients reacquired PA within 3-25 months during the 3 years of follow-up. Fourteen patients acquired a new PA strain with a distinct genotypic profile, suggesting a new source of contamination. Five patients had two PA isolates with identical genotypes, suggesting either previous undetected respiratory tract colonization or a persistent environmental source of contamination.


Asunto(s)
Fibrosis Quística/tratamiento farmacológico , ADN Bacteriano/análisis , Quimioterapia Combinada/administración & dosificación , Neumonía Bacteriana/tratamiento farmacológico , Infecciones por Pseudomonas/tratamiento farmacológico , Pseudomonas aeruginosa/genética , Administración por Inhalación , Administración Oral , Ceftazidima/administración & dosificación , Niño , Preescolar , Enfermedad Crónica , Colistina/administración & dosificación , Recuento de Colonia Microbiana , Fibrosis Quística/microbiología , Electroforesis en Gel de Campo Pulsado , Femenino , Genotipo , Humanos , Imipenem/administración & dosificación , Lactante , Masculino , Neumonía Bacteriana/diagnóstico , Infecciones por Pseudomonas/diagnóstico , Pseudomonas aeruginosa/efectos de los fármacos , Medición de Riesgo , Tobramicina/administración & dosificación
10.
Arch Pediatr ; 5(4): 400-3, 1998 Apr.
Artículo en Francés | MEDLINE | ID: mdl-9759160

RESUMEN

UNLABELLED: Cystic fibrosis is a common and potentially life-threatening hereditary disease which can affect numerous organs, particularly the digestive tract. CASE REPORT: A 4.5-year-old boy exhibited two little known clinical manifestations: an appendiceal mucocele and repeated intussusceptions. In spite of an appendectomy, intussusception relapsed and an ileocolic resection was necessary 2 years later. DISCUSSION: Appendiceal diseases in cystic fibrosis represent a large spectrum, ie, distention on the appendiceal lumen, engorged with sticky mucous matter, which becomes an appendiceal mucocele, peritonitis with an appendiceal perforation due to delayed diagnosis since acute appendicitis is difficult to diagnose in these patients. Intussusception is rarely observed in cystic fibrosis. CONCLUSION: Appendiceal mucocele could be a cause of intussusception. If an appendectomy is performed, resection of a part of the cecum, around the appendix, could be useful in preventing again mucocele formation.


Asunto(s)
Apéndice , Fibrosis Quística/complicaciones , Intususcepción/complicaciones , Mucocele/complicaciones , Apendicectomía , Enfermedades del Ciego/complicaciones , Enfermedades del Ciego/cirugía , Preescolar , Humanos , Intususcepción/cirugía , Masculino , Mucocele/cirugía , Recurrencia
13.
J Infect ; 33(1): 49-51, 1996 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-8842996

RESUMEN

We describe a case of candidaemia in a paediatric cystic fibrosis (CF) patient with a totally implantable vascular access (TIVA). Serial quantitative blood cultures during therapy with amphotericin B delivered via the catheter suggested that the patient was responding to therapy. The TIVA was finally removed because of persistent fever, but its culture remained sterile. Randomly amplified polymorphic DNA (RAPD) analysis of Candida albicans from various anatomical sites showed that the patient's sputum was the most likely source of TIVA contamination. Investigation of TIVA-related candidaemia by molecular analysis could guide rational antifungal chemoprophylaxis of TIVA-related candidaemia.


Asunto(s)
Candidiasis/tratamiento farmacológico , Catéteres de Permanencia/efectos adversos , Fibrosis Quística/complicaciones , Fungemia/tratamiento farmacológico , Anfotericina B/uso terapéutico , Candidiasis/diagnóstico , Niño , ADN de Hongos/análisis , Femenino , Fungemia/diagnóstico , Humanos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...