[Efficacy and safety of vildagliptin as a second-line therapy vs other oral antidiabetic agents in patients with type 2 diabetes: Czech results within the worldwide prospective cohort EDGE study]. / Úcinnost a bezpecnost vildagliptinu jako léku druhé volby ve srovnání s jinými perorálními antidiabetiky u pacientu s diabetes mellitus 2. typu: ceské výsledky v rámci celosvetové prospektivní kohortové studie EDGE.

INTRODUCTION: Metformin monotherapy is recommended as initial treatment of type 2 diabetes. The selection of optimal second-line therapy that is often necessary due to the progressive nature of the disease is still a subject of ongoing discussions. AIM OF THE STUDY: The aim of the international EDGE (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) study was to prospectively compare the efficacy and safety of vildagliptin vs other oral antidiabetic agents in patients with type 2 diabetes not adequately controlled on monotherapy in a real-life clinical setting. In this paper, we present the data of patients participating in the EDGE study in the Czech Republic. MATERIAL AND METHODS: Patients with type 2 diabetes not adequately controlled on monotherapy were enrolled into the study, and randomised into either the vildagliptin arm or control arm with another OAD at the discretion of the treating physician. Patients with the addition of other incretin-based medications were not enrolled into the study. The efficiency was evaluated as a proportion of patients reaching the combined endpoint of decreasing HbA1c> 3 mmol/mol without hypoglycaemia, peripheral oedema or treatment termination due to gastrointestinal side effects during the 12 months of treatment. RESULTS: 654 patients were enrolled into the study in the Czech Republic. The mean age of the patients when enrolled into the study (vildagliptin group vs control group) was 59.5 ± 10.6 vs 63.7 ± 8.5 years, mean body mass index was 32.4 ± 5.7 vs 31.7 ± 6.5 kg/m2, mean HbA1c was 62 ± 12 vs 64 ± 11 mmol/mol. The probability of reaching the combined primary endpoint (calculated using a binary logistic regression model to calculate the odds ratios with 95% confidence intervals) was higher for vildagliptin regardless of baseline HbA1c or type of medication added in the control group. Primary endpoint was reached by 60.6 % of patients in the vildagliptin group vs 51.3 % of patients in the control group, odds ratio 1.46 (1.06, 1.99); p< 0.019. The proportion of patients reaching secondary endpoint (HbA1c< 54 mmol/mol without hypoglycemic event or weight gain 3 % with baseline glycated hemoglobin > 54 mmol/mol was higher for vildagliptin 45.7 % vs 31.4 % in the control arm, odds ratio 1.84 (1.26, 2.68), p< 0.001. The rate of adverse events was comparable in both groups. CONCLUSION: In a real-life clinical set-ting, the percentage of patients reaching the combined endpoint of decreasing HbA1c> 3 mmol/mol, without hypoglycaemia, peripheral oedema or treatment termination due to gastrointestinal side effects was higher after the addition of vildagliptin as compared to other antidiabetic agents with comparable rate of side effects.

[Study in dental laboratories: I. Complete dentures]. / Fogtechnikai laboratóriumban végzett vizsgálatok: I. a teljes fogpótlások.

Introducing the quality control of ISO-900 into dentistry is very urgent and important task nowadays. In this article we report about: how we should be able to double check and evaluate the clinical part of the work in the dental laboratories. What kind of possibilities we have and how dependable they are, in order to control the different phases of the dental work. We also looked into the question whether dental technician get enough and dependable information from the dentists in order to make quality high standard work.

[Experience with partial removable dentures anchored by the Vigano attachment]. / Tapasztalataink a Vigano-féle finommechanikai eszközzel elhorgonyzott részleges lemezes fogpótlásokkal.

In 1993 the Vigano attachment appeared in Hungarian commercial turnover. On the basis of 20 cases observed during one year it can be stated, that the use is simple for dental technicians, the fitting effect is good, requires small place, insertion and removal is easy for elderly and handicapped patients; it is aesthetically satisfying and the design ensures minimum likelihood of repairs.

[Anchoring of partial dentures using OT-CAP precision attachments]. / Részleges lemezes pótlások elhorgonyzása OT-CAP finommechanikai rögzítöeszközökkel.

The authors have examined a precision attachment recently invented in Hungary. They are reporting about the experience gained during clinical examination of dentures made in different classes on the basis of the Fábián and Fejérdy classification of partial edentulousness.

[Possibility of follow-up evaluation of single-piece fixed dentures]. / Az egybeöntött rögzített fogpótlások ellenörzésének lehetösége a gyakorlatban.

The method of the so called "Silodent"-type (silicon gum impression material of medium flowing eonsisteney, Ferrokémia, Budapest) is reported on.