G-protein-coupled receptors encoded by human herpesviruses.

G-protein-coupled receptors (GPCRs) encoded by herpesviruses and poxviruses are homologous to mammalian chemokine receptors. GPCRs encoded by herpesvirus-6, herpesvirus-7, herpesvirus-8 and cytomegalovirus are among the best studied. Virally encoded GPCRs engage many different signal-transduction cascades, and have important roles in the life-cycles of the viruses and pathogenesis of human disease. Although signaling by these GPCRs might be modified by ligand binding, they often exhibit constitutive (basal) signaling activities that appear to provide selective advantages to the virus.