A new metaphor-less simple algorithm based on Rao algorithms: a Fully Informed Search Algorithm (FISA).

Many important engineering optimization problems require a strong and simple optimization algorithm to achieve the best solutions. In 2020, Rao introduced three non-parametric algorithms, known as Rao algorithms, which have garnered significant attention from researchers worldwide due to their simplicity and effectiveness in solving optimization problems. In our simulation studies, we have developed a new version of the Rao algorithm called the Fully Informed Search Algorithm (FISA), which demonstrates acceptable performance in optimizing real-world problems while maintaining the simplicity and non-parametric nature of the original algorithms. We evaluate the effectiveness of the suggested FISA approach by applying it to optimize the shifted benchmark functions, such as those provided in CEC 2005 and CEC 2014, and by using it to design mechanical system components. We compare the results of FISA to those obtained using the original RAO method. The outcomes obtained indicate the efficacy of the proposed new algorithm, FISA, in achieving optimized solutions for the aforementioned problems. The MATLAB Codes of FISA are publicly available at https://github.com/ebrahimakbary/FISA.

A hybridizing-enhanced differential evolution for optimization.

Differential evolution (DE) belongs to the most usable optimization algorithms, presented in many improved and modern versions in recent years. Generally, the low convergence rate is the main drawback of the DE algorithm. In this article, the gray wolf optimizer (GWO) is used to accelerate the convergence rate and the final optimal results of the DE algorithm. The new resulting algorithm is called Hunting Differential Evolution (HDE). The proposed HDE algorithm deploys the convergence speed of the GWO algorithm as well as the appropriate searching capability of the DE algorithm. Furthermore, by adjusting the crossover rate and mutation probability parameters, this algorithm can be adjusted to pay closer attention to the strengths of each of these two algorithms. The HDE/current-to-rand/1 performed the best on CEC-2019 functions compared to the other eight variants of HDE. HDE/current-to-best/1 is also chosen as having superior performance to other proposed HDE compared to seven improved algorithms on CEC-2014 functions, outperforming them in 15 test functions. Furthermore, jHDE performs well by improving in 17 functions, compared with jDE on these functions. The simulations indicate that the proposed HDE algorithm can provide reliable outcomes in finding the optimal solutions with a rapid convergence rate and avoiding the local minimum compared to the original DE algorithm.

The effect of different aero handlebar positions on aerodynamic and gas exchange variables.

Adopting the time trial position (TTP) represents a notable improvement for cycling aerodynamic performance. Aero handlebars are designed to enable the cyclist to adopt a more aerodynamic TTP. However, it is unclear to what realistic extent the aero handlebar configuration affects the aerodynamics and physiological functioning. Thus this study aimed to investigate the effect of aero handlebar alterations on gas exchange parameters and aerodynamics of TTP. Seven male competitive cyclists and triathletes performed submaximal tests on a cycle ergometer at six different TTPs. Oxygen uptake, respiratory exchange ratio, minute ventilation and tidal volume were collected. Using the computational fluid dynamics (CFD) method, the detailed airflow patterns around the cyclist were investigated. The results were analyzed in terms of drag area, velocity and pressure distributions around the cyclist, surface pressure coefficient and wall shear stress magnitude. It was revealed that varying the aero handlebar position significantly influences aerodynamic performance, while maximal values of all the gas exchange variables remained unchanged. Compared to the cyclist's preferred TTP, the frontal area, drag coefficient and drag area were reduced by 4.1%, 4.6% and 8.5%, respectively, when lowering the handlebar position by 5 cm, which overcomes the metabolic costs.

Plantas tolerantes a la sal como un recurso valioso para la producción sostenible de alimentos en zonas costeras áridas y salinasa / Salt tolerant plants as a valuable resource for sustainable food production in arid and saline coastal zones

ABSTRACT This review focuses on the potential of halophytes for food, fodder and biofuels production, as well as their impacts on the environment and societies. Moreover, to open new areas in production systems using novel technologies such as halophytes in a desert agriculture. We are faced with the crisis and the shortage of freshwater in arid, semi-arid and desert regions. For this reason, we have to apply sustainable systems for human food, fodder and biofuels. Halophytes are naturally resistant to salt and develop on the coastal coast and arid-saline areas. We present a complete summary of the current situation of human population growth and food demand, a sustainable alternative such as halophilic crops of agro-industrial importance compared with conventional crops and how they can be incorporated into agriculture sustainable in arid, desert and coastal areas, basing the above on success stories.

RESUMEN Esta revisión se centra en el potencial de las halófitas para la producción de alimentos, forrajes y biocombustibles, así como en sus impactos en el medio ambiente y en las sociedades. Asimismo, en las nuevas áreas que buscan sistemas de producción utilizando tecnologías novedosas como las halófitas en agricultura en el desierto. Nos encontramos ante una crisis de escasez de agua dulce en regiones áridas, semiáridas y desérticas. Por esta razón, tenemos que aplicar sistemas sostenibles para alimento humano, forraje y biocombustibles. Las halofítas son naturalmente resistentes a la sal y se desarrollan en litorales costeros y zonas árido-salinas. Presentamos un resumen completo de la situación actual del crecimiento de la población humana y de la demanda de alimentos, de los cultivos halófilos de importancia agroindustrial como una alternativa sustentable, comparados con los convencionales, y de la forma como se pueden incorporar en una agricultura sustentable en zonas áridas, desérticas y costeras, fundamentando lo anterior con casos de éxito.

Precision Medicine Approach in Prostate Cancer.

Prostate cancer is the most prevalent type of cancer and the second cause of death in men worldwide. Various diagnostic and treatment procedures are available for this type of malignancy, but High-grade or locally advanced prostate cancers showed the potential to develop to lethal phase that can be causing dead. Therefore, new approaches are needed to prolong patients' survival and to improve their quality of life. Precision medicine is a novel emerging field that plays an essential role in identifying new sub-classifications of diseases and in providing guidance in treatment that is based on individual multi-omics data. Multi-omics approaches include the use of genomics, transcriptomics, proteomics, metabolomics, epigenomics and phenomics data to unravel the complexity of a disease-associated biological network, to predict prognostic biomarkers, and to identify new targeted drugs for individual cancer patients. We review the impact of multi-omics data in the framework of systems biology in the era of precision medicine, emphasising the combination of molecular imaging modalities with highthroughput techniques and the new treatments that target metabolic pathways involved in prostate cancer.

Correction: Ghasemi, M., et al. Increase of Chamazulene and α-Bisabolol Contents of the Essential Oil of German Chamomile (Matricaria chamomilla L.) Using Salicylic Acid Treatments under Normal and Heat Stress Conditions Foods 2016, 5, 56.

The authors wish to make the following corrections to their paper [...].

Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis.

This paper presents a review of the importance and role of precision medicine and molecular imaging technologies in cancer diagnosis with therapeutics and diagnostics purposes. Precision medicine is progressively becoming a hot topic in all disciplines related to biomedical investigation and has the capacity to become the paradigm for clinical practice. The future of medicine lies in early diagnosis and individually appropriate treatments, a concept that has been named precision medicine, i.e. delivering the right treatment to the right patient at the right time. Molecular imaging is quickly being recognized as a tool with the potential to ameliorate every aspect of cancer treatment. On the other hand, emerging high-throughput technologies such as omics techniques and systems approaches have generated a paradigm shift for biological systems in advanced life science research. In this review, we describe the precision medicine, difference between precision medicine and personalized medicine, precision medicine initiative, systems biology/medicine approaches (such as genomics, radiogenomics, transcriptomics, proteomics, and metabolomics), P4 medicine, relationship between systems biology/medicine approaches and precision medicine, and molecular imaging modalities and their utility in cancer treatment and diagnosis. Accordingly, the precision medicine and molecular imaging will enable us to accelerate and improve cancer management in future medicine.

Increase of Chamazulene and α-Bisabolol Contents of the Essential Oil of German Chamomile (Matricaria chamomilla L.) Using Salicylic Acid Treatments under Normal and Heat Stress Conditions.

The chamazulene and α-(-)-bisabolol contents and quality of the chamomile oil are affected by genetic background and environmental conditions. Salicylic acid (SA), as a signaling molecule, plays a significant role in the plant physiological processes. The aim of this study was to evaluate the chemical profile, quantity, and improve the essential oil quality as a consequence of the increase of chamazulene and α-(-)-bisabol using salicylic acid under normal and heat stress conditions by the gas chromatography-mass spectrometry (GC-MS) technique. The factorial experiments were carried out during the 2011-2012 hot season using a randomized complete block design with three replications. The factors include four salicylic acid concentrations (0 (control), 10, 25 and 100 mg·L-1), and three chamomile cultivars (Bushehr, Bona, Bodegold) were sown on two different planting dates under field conditions. Fourteen compounds were identified from the extracted oil of the samples treated with salicylic acid under normal and heat stress conditions. The major identified oil compositions from chamomile cultivars treated with salicylic acid were chamazulene, α-(-)-bisabolol, bisabolone oxide, ß-farnesene, en-yn-dicycloether, and bisabolol oxide A and B. Analysis of variance showed that the simple effects (environmental conditions, cultivar and salicylic acid) and their interaction were significant on all identified compounds, but the environmental conditions had no significant effect on bisabolol oxide A. The greatest amount of chamazulene obtained was 6.66% at the concentration of 10 mg·L-1 SA for the Bona cultivar under heat stress conditions, whereas the highest α-(-)-bisabolol amount attained was 3.41% at the concentration of 100 mg·L-1 SA for the Bona cultivar under normal conditions. The results demonstrated that the application of exogenous salicylic acid increases the quantity and essential oil quality as a consequence of the increase of chamazulene and α-(-)-bisabolol under normal and heat stress conditions.

Health inequalities and development plans in Iran; an analysis of the past three decades (1984-2010).

INTRODUCTION: Reducing inequalities in health care is one of the main challenges in all countries. In Iran as in other oil-exporting upper middle income countries, we expected to witness fewer inequalities especially in the health sector with the increase in governmental revenues. METHODS: This study presents an inequalities assessment of health care expenditures in Iran. We used data from the Household Income and Expenditure Survey (HIES) in Iran from 1984-2010. The analysis included 308,735 urban and 342,532 rural households. RESULTS: The results suggest heightened inequality in health care expenditures in Iran over the past three decades, including an increase in the gap between urban and rural areas. Furthermore, inflation has affected the poor more than the rich. The Kakwani progressivity index in all years is positive, averaging 0.436 in rural and 0.470 in urban areas during the time period of analysis. Compared to inequality in income distribution over the last 30 years, health expenditures continuously show more inequality and progressivity over the same period of time. CONCLUSIONS: According to the result of our study, during this period Iran introduced four National Development Plans (NDPs); however, the NDPs failed to provide sustainable strategies for reducing inequalities in health care expenditures. Policies that protect vulnerable groups should be prioritized.

Cytomegalovirus localization in atherosclerotic plaques is associated with acute coronary syndromes: report of 105 patients.

It has been shown that cytomegalovirus (CMV) is present in coronary atherosclerotic plaques, but the clinical relevance of this presence remains to be elucidated. In this study we sought to examine CMV infection in atherosclerosis patients defined by different methods and to identify the clinical significance of CMV replication in the atherosclerotic plaques. The study included 105 consecutive patients who were admitted to our department and underwent coronary artery bypass grafting (CABG) surgical interventions. Coronary atherosclerotic specimens as well as 53 specimens from the mamillary artery of these same patients were analyzed. Enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) methods were used for evaluations. The CMV PCR test result was positive for 28 (26.7%) of patients with coronary artery atherosclerosis. After adjusting for other risk factors, coronary artery disease patients with a history of acute coronary syndrome were more likely to be positive for CMV PCR test (P=0.027; odds ratio: 4.2; 95% CI: 1.18-15.0). They were also more likely to have a positive family history for cardiovascular diseases (CVD). This study confirms previous evidence about the replication of CMV virus in the atherosclerotic plaques of coronary arteries and brings clinical significance to this observation by showing a higher prevalence of acute coronary syndromes in those patients with CMV-infected plaques. Our study also suggests a familial vulnerability to CMV replication in the coronary artery walls.