The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease.

Increasing evidence suggests that Alzheimer's disease (AD) and Parkinson's disease (PD) share monoamine and alpha-synuclein (αSyn) dysfunctions, often beginning years before clinical manifestations onset. The triggers for these impairments and the causes leading these early neurodegenerative processes to become AD or PD remain unclear. We address these issues by proposing a radically new perspective to frame AD and PD: they are different manifestations of one only disease we call "Neurodegenerative Elderly Syndrome (NES)". NES goes through three phases. The seeding stage, which starts years before clinical signs, and where the part of the brain-body affected by the initial αSyn and monoamine dysfunctions, influences the future possible progression of NES towards PD or AD. The compensatory stage, where the clinical symptoms are still silent thanks to compensatory mechanisms keeping monoamine concentrations homeostasis. The bifurcation stage, where NES becomes AD or PD. We present recent literature supporting NES and discuss how this hypothesis could radically change the comprehension of AD and PD comorbidities and the design of novel system-level diagnostic and therapeutic actions.

Emotions Modulate Affordances-Related Motor Responses: A Priming Experiment.

Traditionally, research on affordances and emotions follows two separate routes. For the first time, this article explicitly links the two phenomena by investigating whether, in a discrimination task (artifact vs. natural object), the motivational states induced by emotional images can modulate affordances-related motor response elicited by dangerous and neutral graspable objects. The results show faster RTs: (i) for both neutral and dangerous objects with neutral images; (ii) for dangerous objects with pleasant images; (iii) for neutral objects with unpleasant images. Overall, these data support a significant effect of emotions on affordances. The article also proposes a brain neural network underlying emotions and affordance interplay.

Motor Inhibition to Dangerous Objects: Electrophysiological Evidence for Task-dependent Aversive Affordances.

Previous work suggests that perception of an object automatically facilitates actions related to object grasping and manipulation. Recently, the notion of automaticity has been challenged by behavioral studies suggesting that dangerous objects elicit aversive affordances that interfere with encoding of an object's motor properties; however, related EEG studies have provided little support for these claims. We sought EEG evidence that would support the operation of an inhibitory mechanism that interferes with the motor encoding of dangerous objects, and we investigated whether such mechanism would be modulated by the perceived distance of an object and the goal of a given task. EEGs were recorded by 24 participants who passively perceived dangerous and neutral objects in their peripersonal, boundary, or extrapersonal space and performed either a reachability judgment task or a categorization task. Our results showed that greater attention, reflected in the visual P1 potential, was drawn by dangerous and reachable objects. Crucially, a frontal N2 potential, associated with motor inhibition, was larger for dangerous objects only when participants performed a reachability judgment task. Furthermore, a larger parietal P3b potential for dangerous objects indicated the greater difficulty in linking a dangerous object to the appropriate response, especially when it was located in the participants' extrapersonal space. Taken together, our results show that perception of dangerous objects elicits aversive affordances in a task-dependent way and provides evidence for the operation of a neural mechanism that does not code affordances of dangerous objects automatically, but rather on the basis of contextual information.

Spinocerebellar ataxia: a critical review of cognitive and socio-cognitive deficits.

PURPOSE: The primary aim of this contribution is to provide a critical discussion on cognitive and sociocognitive implications of spinocerebellar ataxias (SCAs) subtypes. The term SCA refers to a group of neurodegenerative disorders that have been increasingly investigated in the last years, sharing the characteristic of progressive ataxia resulting from degeneration of cerebellum and its connections. In past decades only involvement of cerebellum in behaviour and timing has been investigated, bringing to the belief about its central role in timing of movement and sensation, particularly for short intervals of time. Only very recently the cerebellum has been considered as a potentially important centre for cognitive processing and related spheres of social cognition, so that several studies with SCA patients have been carried out on these topics: as a consequence a section of this review will be dedicated to this important aspect. RESULTS: After a brief discussion on most commonly used methods to assess cognitive and socio-cognitive abilities in SCAs, cognitive and socio-cognitive profiles of principal SCA subtypes have been thoroughly reviewed and critically discussed. Due to the very poor literature in this field the most common SCA variants have been fully included (i.e. SCA1, SCA2, SCA3, SCA6 and SCA7). CONCLUSIONS: A comparative summary of the main characteristics of cognitive and social cognition deficit in SCA subtypes has been proposed together with a research agenda for future investigation in this field principally aimed at using measures of cognition and/or social cognition as potential predictors of the extent and progression of disease.