Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: a meta-analysis of adjusted observational results.

AIMS: Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. METHODS AND RESULTS: Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I(2) 0%). CONCLUSION: CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

[A computer program to retrieve and record ISTAT codes related to pediatric diagnosis]. / Un programma per reperimento e archiviazione dei codici ISTAT relativi a diagnosi pediatriche.

The paper describes a computer program that retrieves ISTAT codes increasing the efficiency of the retrieving time spent with traditional methods storing the obtained information in a suitable data-base, which may be lately explored by means of commercial programs. To increase the detail of the stored data, many of the official codes have been expanded with an extra character. Some results obtained from an experience conducted at the Pediatric Division of Crema Hospital are also reported.

Movement-related brain macropotentials during skilled performances. A developmental study.

A developmental study of movement-related brain macropotentials (MRBMs) during a self-paced bimanual skilled performance task (Papakostopoulos 1980) was carried out. MRBMs were obtained from Fpz, Cz and right and left pre-central and electromyograms were recorded from the left and right flexor muscles of the forearms in 30 normal children ranging from 8 to 13 years of age. A consistent Bereitschaftspotential appeared in children of 10 years; in the younger children it was absent or it was positive at precentral and central locations. The motor cortex potential and P200 were present in all children. The skilled performance positivity (SPP), absent at 8 and 9 years, appeared at 11 years of age and was present in older children. The latency of P200 and SPP decreased with age. ANOVA tests showed a statistically significant age effect on performance, EMG rise time and MRBMs; MRBMs were not statistically influenced by time in the experiment: MCP and P200 increased in amplitude with improvement of performance. The results indicate different rates of maturation of the neuronal systems underlying the genesis of the various movement-related brain macropotentials.