Hardware and Software Setup for Quantitative 23Na Magnetic Resonance Imaging at 3T: A Phantom Study.

Magnetic resonance (MR) with sodium (23Na) is a noninvasive tool providing quantitative biochemical information regarding physiology, cellular metabolism, and viability, with the potential to extend MR beyond anatomical proton imaging. However, when using clinical scanners, the low detectable 23Na signal and the low 23Na gyromagnetic ratio require the design of dedicated radiofrequency (RF) coils tuned to the 23Na Larmor frequency and sequences, as well as the development of dedicated phantoms for testing the image quality, and an MR scanner with multinuclear spectroscopy (MNS) capabilities. In this work, we propose a hardware and software setup for evaluating the potential of 23Na magnetic resonance imaging (MRI) with a clinical scanner. In particular, the reliability of the proposed setup and the reproducibility of the measurements were verified by multiple acquisitions from a 3T MR scanner using a homebuilt RF volume coil and a dedicated sequence for the imaging of a phantom specifically designed for evaluating the accuracy of the technique. The final goal of this study is to propose a setup for standardizing clinical and research 23Na MRI protocols.

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review.

Cardiovascular disease shows, or may even be caused by, changes in metabolism. Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could assess the role of different aspects of metabolism in heart disease, allowing real-time metabolic flux assessment in vivo. In this review, we introduce the main hyperpolarization techniques. Then, we summarize the use of dedicated radiofrequency 13C coils, and report a state of the art of 13C data acquisition. Finally, this review provides an overview of the pre-clinical and clinical studies on cardiac metabolism in the healthy and diseased heart. We furthermore show what advances have been made to translate this technique into the clinic in the near future and what technical challenges still remain, such as exploring other metabolic substrates.

Dual-Channel Transverse Fields Radiofrequency Coils for 1.5 T Magnetic Resonance Imaging.

This theoretical study presents the design and analytical/numerical optimization of novel dual-channel transverse fields radiofrequency (RF) surface coils for 1.5 T Magnetic Resonance Imaging (MRI). The research explores a planar setup with two channels on a row with aligned spatial orientation of the RF coils, aiming to solve a common design drawback of single-channel transverse field RF coils: the reduced Field Of View (FOV) along the direction of the RF field. A significant challenge in this design is the efficient decoupling of two sets of transverse field RF coils to prevent mutual interference. Our modeling approach integrates thin wire theoretical modeling, magnetostatic computation for strip conductor coils, and their full-wave electromagnetic simulation. Key findings at 64 MHz demonstrate that strategic geometric placement among the two-channel RF coil and the introduction of geometrical asymmetry in the design of the individual RF coils does minimize the mutual inductance, paving the way for effective dual-channel MRI applications. This decoupling approach allows to enhance the FOV, providing a theoretical framework for the development of optimized dual-channel transverse field RF coil configurations. The current design was validated with full-wave numerical study at 64 MHz (1H, 1.5 T), has the potential to be extended at lower or higher frequencies, and the presence of lossy samples needs to be considered in the latter case.

Machine Learning for the Design and the Simulation of Radiofrequency Magnetic Resonance Coils: Literature Review, Challenges, and Perspectives.

Radiofrequency (RF) coils for magnetic resonance imaging (MRI) applications serve to generate RF fields to excite the nuclei in the sample (transmit coil) and to pick up the RF signals emitted by the nuclei (receive coil). For the purpose of optimizing the image quality, the performance of RF coils has to be maximized. In particular, the transmit coil has to provide a homogeneous RF magnetic field, while the receive coil has to provide the highest signal-to-noise ratio (SNR). Thus, particular attention must be paid to the coil simulation and design phases, which can be performed with different computer simulation techniques. Being largely used in many sectors of engineering and sciences, machine learning (ML) is a promising method among the different emerging strategies for coil simulation and design. Starting from the applications of ML algorithms in MRI and a short description of the RF coil's performance parameters, this narrative review describes the applications of such techniques for the simulation and design of RF coils for MRI, by including deep learning (DL) and ML-based algorithms for solving electromagnetic problems.

Conductor Losses in Radiofrequency Coils for Magnetic Resonance below 3T: Estimation Methods and Minimization Strategies.

The design of optimized radiofrequency (RF) coils is a fundamental task for maximizing the signal-to-noise ratio (SNR) in Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) applications. An efficient coil should be designed by minimizing the coil noise with respect to the sample noise, since coil conductor resistance affects data quality by reducing the SNR, especially for coils tuned to a low frequency. Such conductor losses strongly depend on the frequency (due to the skin effect) and on the conductor cross-sectional shape (strip or wire). This paper reviews the different methods for estimating conductor losses in RF coils for MRI/MRS applications, comprising analytical formulations, theoretical/experimental hybrid approaches and full-wave simulations. Moreover, the different strategies for minimizing such losses, including the use of Litz wire, cooled and superconducting coils, are described. Finally, recent emerging technologies in RF coil design are briefly reviewed.

Magnetostatic Simulation and Design of Novel Radiofrequency Coils Based on Transverse Field Current Elements for Magnetic Resonance Applications.

Radiofrequency (RF) coils are key components in Magnetic Resonance (MR) systems and can be categorized into volume and surface coils according to their shapes. Volume RF coils can generate a uniform field in a large central sample's region, while surface RF coils, usually smaller than volume coils, typically have a higher Signal-to-Noise Ratio (SNR) in a reduced Region Of Interest (ROI) close to the coil plane but a relatively poorer field homogeneity. Circular and square loops are the simplest and most used design for developing axial field surface RF coils. However, for specific MR applications, the use of dedicated transverse field RF coils can be necessary or advantageous. Building on a previously developed and validated RF coil simulator, based on the magnetostatic approach, here we explore the potential applications of novel multiple axial field and transverse field surface RF coils in non-standard configurations. We demonstrate via numerical simulations that simple volume RF coils, matching a Helmholtz-like design, can be built with two identical transverse field RF coils separated by a given distance. Following well-known principles, the SNR of such novel configurations can be improved by a factor of up to √2 by combining two 90° rotated coils, producing, inside a central ROI, a circularly polarized B1 field.

Computer tomography and magnetic resonance for multimodal imaging of fossils and mummies.

The study of fossils and mummies has largely benefited from the use of modern noninvasive and nondestructive imaging technologies and represents a fast developing area. In this review, we describe the emerging role of imaging based on Magnetic Resonance (MR) and Computer Tomography (CT) employed for the study of ancient remains and mummies. For each methodology, the state of the art in paleoradiology applications is described, by emphasizing new technologies developed in the field of both CT, such as micro- and nano-CT, dual-energy and multi-energy CT, and MR, with the description of novel dedicated sequences, radiofrequency coils and gradients. The complementarity of CT and MR in paleoradiology is also discussed, by pointing out what MR provides in addition to CT, with an overview on the state of the art of emerging strategies in the use of CT/MR combination for the study of a sample following a multimodal integrated approach.

Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies.

In recent years, the usage of radio frequency magnetic fields for biomedical applications has increased exponentially. Several diagnostic and therapeutic methodologies exploit this physical entity such as, for instance, magnetic resonance imaging, hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation. Within this framework, the magnetic field focusing and shaping, at different depths inside the tissue, emerges as one of the most important challenges from a technological point of view, since it is highly desirable for improving the effectiveness of clinical methodologies. In this review paper, we will first report some of the biomedical practices employing radio frequency magnetic fields, that appear most promising in clinical settings, explaining the underneath physical principles and operative procedures. Specifically, we direct the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging. Additionally, we deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications. In particular, volume and surface coils, together with the recent raise of metamaterials and metasurfaces will be reported. The present review manuscript can be useful to fill the actual gap in the literature and to serve as a guide for the physicians and engineers working in these fields.

Analysis, comparison and representation of occupational exposure to a static magnetic field in a 3-T MRI site.

The purpose of this study is to analyze exposure to the time-varying magnetic field caused by worker movements in a 3-T clinical magnetic resonance imaging (MRI) scanner. Measurements of the static magnetic field (B) in the proximity of the MRI scanner were performed to create a detailed map of the spatial gradient of B, in order to indicate the areas at high risk of exposure. Moreover, a personal exposure recording system was used in order to analyze and compare exposure to the static magnetic field during different routine procedures in MRI. We found that for all of the performed work activities, exposure was compliant with International Commission on Non-Ionizing Radiation Protection levels. However, our findings confirm that there is great variability of exposure between different workers and suggest the importance of performing personal exposure measurements and of detailed knowledge of the magnetic field spatial distribution.

Occupational exposure to electromagnetic fields in magnetic resonance environment: an update on regulation, exposure assessment techniques, health risk evaluation, and surveillance.

Magnetic resonance imaging (MRI) is one of the most-used diagnostic imaging methods worldwide. There are ∼50,000 MRI scanners worldwide each of which involves a minimum of five workers from different disciplines who spend their working days around MRI scanners. This review analyzes the state of the art of literature about the several aspects of the occupational exposure to electromagnetic fields (EMF) in MRI: regulations, literature studies on biological effects, and health surveillance are addressed here in detail, along with a summary of the main approaches for exposure assessment. The original research papers published from 2013 to 2021 in international peer-reviewed journals, in the English language, are analyzed, together with documents published by legislative bodies. The key points for each topic are identified and described together with useful tips for precise safeguarding of MRI operators, in terms of exposure assessment, studies on biological effects, and health surveillance.

Design, simulation, and test of surface and volume radio frequency coils for 13C magnetic resonance imaging and spectroscopy.

Hyperpolarized 13C Magnetic Resonance (MR) is a promising technique for in vivo non-invasive assessment of metabolism in humans. Despite the considerable signal increase provided by hyperpolarization techniques, the low molar concentration of derivate 13C metabolites gives rise to technological limits in terms of data quality. The development of dedicated radio frequency coils, capable of providing a large field of view with high signal-to-noise ratio data, is thus a fundamental task. This work describes the design, simulation, and test of a surface and a volume coil, both designed to be integrated with a clinical scanner for hyperpolarized 13C studies in small animal models, with the purpose to provide a detailed characterization and comparison of their performance. In particular, coil inductance was evaluated with analytical calculation, while the magnetostatic theory was employed for coils magnetic field pattern estimation. Workbench tests permitted us to characterize coil performance in terms of quality factor and efficiency. Additionally, this Tutorial summarizes the acquisition experience for the reconstruction of 13C spectroscopic maps in phantom using the two designed coils and a 3 T MR clinical scanner. We believe that this Tutorial could be interesting for graduate students and researchers in the field of magnetic resonance coil design and development, especially for 13C studies.

The Procedure for Quantitative Characterization and Analysis of Magnetic Fields in Magnetic Resonance Sites for Protection of Workers: A Pilot Study.

Concerning the occupational exposure in magnetic resonance imaging (MRI) facilities, the worker behavior in the magnetic resonance (MR) room is of such particular importance that there is the need for a simple but reliable method to alert the worker of the highest magnetic field exposure. Here, we describe a quantitative analysis of occupational exposure in different MRI working environments: in particular, we present a field measurement method integrated with a software tool for an accurate mapping of the fringe field in the proximity of the magnetic resonance bore. Three illustrative assessment studies are finally presented, compared and discussed, considering an example of a realistic path followed by an MRI worker during the daily procedure. The results show that the basic restrictions set by ICNIRP can be exceeded during standard procedure even in 1.5 T scanners. Using the described simplified metrics, it is possible to introduce behavioral rules on how to move around an MRI room that could be more useful than a numerical limit to aid magnetic field risk mitigation strategies.

Artifacts by Misalignment of Cardiac Magnetic Resonance Phased-array Coil Elements: From Simulation to In vivo Test.

BACKGROUND: Cardiac magnetic resonance evaluations generally require a radiofrequency coil setup comprising a transmit whole-body coil and a receive coil. In particular, radiofrequency phased-array coils are employed to pick up the signals emitted by the nuclei with high signal-tonoise ratio and a large region of sensitivity. METHODS: Literature discussed different technical issues on how to minimize interactions between array elements and how to combine data from such elements to yield optimum Signal-to-Noise Ratio images. However, image quality strongly depends upon the correct coil position over the heart and of one array coil portion with respect to the other. RESULTS: In particular, simple errors in coil positioning could cause artifacts carrying to an inaccurate interpretation of cardiac magnetic resonance images. CONCLUSION: This paper describes the effect of array elements misalignment, starting from coil simulation to cardiac magnetic resonance acquisitions with a 1.5 T scanner. Phased-array coil simulation was performed using the magnetostatic approach; moreover, phantom and in vivo experiments with a commercial 8-elements cardiac phased-array receiver coil permitted to estimate signal-to-noise ratio and B1 mapping for aligned and shifted coil.

TOWARDS A PERSONALISED AND INTERACTIVE ASSESSMENT OF OCCUPATIONAL EXPOSURE TO MAGNETIC FIELD DURING DAILY ROUTINE IN MAGNETIC RESONANCE.

Magnetic resonance imaging (MRI) is one of the most common sources of electromagnetic (EM) fields as a diagnostic technique widely used in medicine. MRI staff during the working day is constantly exposed to static and spatially heterogeneous magnetic field. Also, moving around the MRI room to perform their functions, workers are exposed to slowly time-varying magnetic fields that induce electrical currents and fields in the body. The development of new exposure assessment methodologies to collect exposure data at a personal level using simple everyday equipment is hence necessary, also in view of future epidemiological studies. This paper describes the design and testing of a novel device for assessing personal exposure to static and time-varying magnetic fields during daily clinical practice. The dosemeter will be also used to ensure effective training of technicians who will be instructed to avoid, where possible, risk behaviour in terms of high exposure.

Biomolecular imaging of 13C-butyrate with dissolution-DNP: Polarization enhancement and formulation for in vivo studies.

Magnetic Resonance Spectroscopy of hyperpolarized isotopically enriched molecules facilitates the non-invasive real-time investigation of in vivo tissue metabolism in the time-frame of a few minutes; this opens up a new avenue in the development of biomolecular probes. Dissolution Dynamic Nuclear Polarization is a hyperpolarization technique yielding a more than four orders of magnitude increase in the 13C polarization for in vivo Magnetic Resonance Spectroscopy studies. As reported in several studies, the dissolution Dynamic Nuclear Polarization polarization performance relies on the chemico-physical properties of the sample. In this study, we describe and quantify the effects of the different sample components on the dissolution Dynamic Nuclear Polarization performance of [1-13C]butyrate. In particular, we focus on the polarization enhancement provided by the incremental addition of the glassy agent dimethyl sulfoxide and gadolinium chelate to the formulation. Finally, preliminary results obtained after injection in healthy rats are also reported, showing the feasibility of an in vivo Magnetic Resonance Spectroscopy study with hyperpolarized [1-13C]butyrate using a 3T clinical set-up.

Radiofrequency magnetic resonance coils and communication antennas: Simulation and design strategies.

Coils simulation and design is a fundamental task to maximize Signal-to-Noise Ratio in Magnetic Resonance applications. In the meantime, in the last years the issue of accurate communication antennas analysis has grown. Coil design techniques take advantage of computer simulations in dependence on the magnetic field wavelength and coil sizes. In particular, since at high frequencies coils start to behave as antennas, modern Magnetic Resonance coil development exploits numerical methods typically employed for antennas simulation. This paper reviews coil and antenna performance parameters and focuses on the different simulation approaches in dependence on the near/far field zones and operating frequency.

A radiofrequency system for in vivo hyperpolarized 13 C MRS experiments in mice with a 3T MRI clinical scanner.

Hyperpolarized carbon-13 magnetic resonance spectroscopy (MRS) is a powerful tool to explore tissue metabolic state, by permitting the study of intermediary metabolism of biomolecules in vivo. However, a number of technological problems still limit this technology and need innovative solutions. In particular, the low molar concentration of derivate metabolites give rise to low signal-to-noise ratio (SNR), which makes the design and development of dedicated radiofrequency (RF) coils a fundamental task. In this article, the authors describe the simulation and the design of a RF coils configuration for MR experiments in mice, constituted by a 1 H whole body volume RF coil for imaging and a 13 C single circular loop surface RF coil for performing 13 C acquisitions. After the building, the RF system was employed in an in vivo experiment in a mouse injected with hyperpolarized [1-13 C]pyruvate by using a 3 T clinical MR scanner. SCANNING 38:710-719, 2016. © 2016 Wiley Periodicals, Inc.

Magnetic resonance spectroscopy and imaging for the study of fossils.

Computed tomography (CT) has long been used for investigating palaeontological specimens, as it is a nondestructive technique which avoids the need to dissolve or ionize the fossil sample. However, magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) have recently gained ground as analytical tools for examination of palaeontological samples, by nondestructively providing information about the structure and composition of fossils. While MRI techniques are able to reveal the three-dimensional geometry of the trace fossil, MRS can provide information on the chemical composition of the samples. The multidimensional nature of MR (magnetic resonance) signals has potential to provide rich three-dimensional data on the palaeontological specimens and also to help in elucidating paleopathological and paleoecological questions. In this work the verified applications and the emerging uses of MRI and MRS in paleontology are reviewed, with particular attention to fossil spores, fossil plants, ambers, fossil invertebrates, and fossil vertebrate studies.

Magnetic resonance imaging for the study of mummies.

Nondestructive diagnostic imaging for mummies study has a long tradition and high-resolution images of the samples morphology have been extensively acquired by using computed tomography (CT). However, although in early reports no signal or image was obtained because of the low water content, mummy magnetic resonance imaging (MRI) was demonstrated able to generate images of such ancient specimens by using fast imaging techniques. Literature demonstrated the general feasibility of nonclinical MRI for visualizing historic human tissues, which is particularly interesting for archeology. More recently, multinuclear magnetic resonance spectroscopy (MRS) was demonstrated able to detect numerous organic biochemicals from such remains. Although the quality of these images is not yet comparable to that of clinical magnetic resonance (MR) images, and further research will be needed for determining the full capacity of MR in this topic, the information obtained with MR can be viewed as complementary to the one provided by CT and useful for paleoradiological studies of mummies. This work contains an overview of the state of art of the emerging uses of MRI in paleoradiology.