Asunto(s)
Enfermedades Transmisibles Importadas/epidemiología , Enfermedades Transmisibles Importadas/virología , Brotes de Enfermedades , Virus del Sarampión/genética , Sarampión/epidemiología , Sarampión/virología , Adulto , Asia Sudoriental/epidemiología , Análisis por Conglomerados , Genotipo , Humanos , Control de Infecciones , Italia/epidemiología , Sarampión/transmisión , Virus del Sarampión/clasificación , Virus del Sarampión/inmunología , Virus del Sarampión/aislamiento & purificación , Persona de Mediana EdadRESUMEN
Human adenoviruses (HAdVs) cause a wide spectrum of clinical syndromes, depending on species and types, from mild respiratory infections to deadly pneumonia: in particular, severe infections occur in immunocompromised patients. In this report, we describe the case of a 36 years-old woman admitted to our intensive care unit (ICU) with severe respiratory distress syndrome caused by adenovirus pneumonia, that required invasive respiratory support (mechanical ventilation and extracorporeal membrane oxygenation). Molecular assays detected the virus in respiratory and plasma specimen and sequencing procedure identified HAdV type 4. Patient improved after cidofovir administration. Leukopenia and subsequent bacterial infection occurred, but the patient recovered completely and was discharged from the hospital after 54days.
Asunto(s)
Infecciones por Adenovirus Humanos , Adenovirus Humanos/genética , Síndrome de Dificultad Respiratoria , Adulto , Cuidados Críticos , ADN Viral/análisis , ADN Viral/genética , Femenino , Hospitalización , Humanos , Tipificación Molecular , Reacción en Cadena de la PolimerasaRESUMEN
The coding sequences of five human enterovirus (HEV)-C genotype 105 strains recovered in Italy, Romania and Burundi from patients with upper and lower respiratory tract infections were analysed and phylogenetically compared with other circulating HEV-C strains. The EV-C105 was closely related to EV-C109 and EV-C118 strains. The European strains were similar to other circulating EV-C105 strains, while the two African EV-C105 clustered in separate bootstrap-supported (>0.90) branches of the P2 and P3 region trees. Minor inconsistencies in the clustering pattern of EV-C105 in the capsid region (P1) and non-capsid region (P3) suggest that recombination may have occurred in EV-C105 group B viruses. In conclusion, phylogenetic analysis revealed the circulation of two distinct EV-C105 lineages in Europe and Africa. A different pattern of evolution could be hypothesized for the two EV-C105 lineages.