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1.
Urology ; 166: 241-245, 2022 08.
Artículo en Inglés | MEDLINE | ID: mdl-35643112

RESUMEN

Fetus in fetu is a rare phenomenon of infancy, separate from conjoined twins, teratomas, and acardiac twins. The pathogenesis is not well understood but has been theorized to originate from either the involution of a twin or the differentiation of a teratoma. While the majority of these are found in the retroperitoneum, the presence of a fetus in fetu within the scrotum is exceedingly rare. We present the diagnosis and management of a case of fetus in fetu in the scrotum of a newborn male including radiologic imaging and pathologic examination.


Asunto(s)
Teratoma , Gemelos Siameses , Abdomen , Feto/diagnóstico por imagen , Feto/patología , Humanos , Recién Nacido , Masculino , Escroto/diagnóstico por imagen , Escroto/patología , Teratoma/diagnóstico por imagen , Teratoma/cirugía
2.
J Pediatr Surg ; 57(9): 174-178, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34518021

RESUMEN

BACKGROUND: Indocyanine green (ICG), a water-soluble tricarbocyanine fluorophore, is being increasingly used for tumor localization based on its passive intra-tumoral accumulation due to enhanced permeability and retention in tumor tissue. Therefore, we hypothesized that ICG can provide contrast to facilitate accurate, real-time recognition of renal tumors at the time of nephron-sparing surgery in children. METHODS: This retrospective study examined the feasibility of ICG in guiding nephron-sparing surgery for pediatric renal tumors. RESULTS: We reviewed the medical records of 8 pediatric patients with renal tumors in 12 kidneys. Intraoperative localization of tumor with near infrared guidance was successful in all 12 kidneys. However, we consistently found an inverse pattern of near infrared signal in which the normal kidney demonstrated increased fluorescent signal relative to the kidney tumor. CONCLUSIONS: Fluorescence-guided renal tumor delineation is unique because it has an inverse pattern of near infrared signal in which the normal kidney demonstrates increased signal relative to the adjacent tumor. Nevertheless fluorescence-guided distinguishing of renal tumor from surrounding normal kidney is feasible.


Asunto(s)
Verde de Indocianina , Neoplasias Renales , Niño , Humanos , Neoplasias Renales/diagnóstico por imagen , Neoplasias Renales/patología , Neoplasias Renales/cirugía , Nefrectomía , Nefronas/cirugía , Estudios Retrospectivos
3.
J Pediatr Hematol Oncol ; 43(8): e1214-e1216, 2021 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-33031160

RESUMEN

BACKGROUND: Extracranial pure malignant rhabdoid tumors (MRT) are aggressive tumors that carry a poor prognosis. Bladder MRTs are very rare and only 8 cases have been reported previously. OBSERVATION: We present a case of a child with bladder MRT. Despite the aggressive nature of the bladder tumor, it was successfully treated with bladder-sparing surgery, adjuvant radiotherapy, and chemotherapy. CONCLUSIONS: Our case, and review of 8 previously reported cases, suggests that bladder MRT seems to behave less aggressively when compared with other extracranial MRTs, and bladder preserving surgery should be considered when feasible.


Asunto(s)
Quimioterapia Adyuvante/métodos , Cistectomía/métodos , Radioterapia Adyuvante/métodos , Tumor Rabdoide/terapia , Neoplasias de la Vejiga Urinaria/terapia , Preescolar , Terapia Combinada , Humanos , Masculino , Pronóstico , Tumor Rabdoide/patología , Neoplasias de la Vejiga Urinaria/patología
4.
Urology ; 146: 207-210, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32822686

RESUMEN

OBJECTIVES: To report our immediate and delayed outcomes of nonstented tubularized incised plate (TIP) distal hypospadias repair. METHODS: We retrospectively reviewed all charts of children who underwent distal hypospadias repair in a single children's hospital from 2013 to 2018. Patients' demographics, hypospadias characteristics, operative technique, and immediate and delayed outcomes were recorded. RESULTS: Of 280 consecutive distal hypospadias repairs that were identified, 74 were excluded due to the use of a repair other than TIP. Eleven stented TIP repairs were excluded as well. Of 195 nonstented repairs, immediate postoperative voiding complications were recorded in 11 (5.6%) and included multiple/split stream in 6 (3%), dysuria and voiding difficulty in 2 (1%), urinary retention in 2 (1%), and gross hematuria that spontaneously resolved in 1 (0.5%). Late follow up was recorded in 142 of 195 (72.8%) repairs. Delayed urethroplasty/glansplasty complications were recorded in 12 (8.5%) and included urethrocutaneous fistula in 10 (7.0%), meatal stenosis in 6 (4.2%) and glans/urethroplasty dehiscence in 2 (1.4%). CONCLUSION: Avoiding postoperative urethral stents in distal hypospadias TIP repair reduces the morbidity associated with the stent and is a feasible option that carries acceptable immediate and delayed complication rates. Avoiding the stent eliminates stent-related bladder spasms, the need for other medications, and the short-term office visit for stent removal, therefore reducing parental anxiety, patient discomfort, and reducing cost.


Asunto(s)
Hipospadias/cirugía , Humanos , Hipospadias/patología , Lactante , Masculino , Estudios Retrospectivos , Stents , Factores de Tiempo , Resultado del Tratamiento , Procedimientos Quirúrgicos Urológicos Masculinos/métodos
5.
Urology ; 121: 158-163, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30125645

RESUMEN

OBJECTIVE: To identify attributes of pediatric patients with hydronephrosis due to ureteropelvic junction obstruction and of their surgical encounters which are predictive of resolution of dilatation in order to provide more effective counseling about expected outcomes. This study was inspired by the suggestion in recent literature that greater than 20% improvement in anteroposterior diameter (APD) of the renal pelvis after pyeloplasty is indicative of resolution of obstruction. The remaining dilatation, however, is often distressing to caregivers, and there are no data to guide clinicians in counseling about its likelihood to resolve. METHODS: We retrospectively reviewed children who underwent surgery at our institution for ureteropelvic junction obstruction between 1/01/2010 and 6/30/2017. APD of the pre- (preAPD) and postoperative (postAPD) renal pelves were documented. In children with more than 1 postoperative ultrasound, lastAPD was the measurement on their most recent study. Appropriate statistical tests examined the effects of clinical and surgical variables on hydronephrosis resolution. RESULTS: PostAPD and lastAPD were obtained at medians of 3 months and 1.9 years after surgery, and were 0 cm in 12 of 105 (11.5%) and 9 of 65 (13.8%) patients, respectively. None of the variables analyzed significantly impacted complete resolution at either time point. Of those that did not resolve, 80.6% (75/93) showed greater than 20% improvement in APD; however, 3 of these children required reoperation due to secondary obstruction. In our study, no one with APD reduction greater than 43% required reintervention. CONCLUSION: Complete resolution of hydronephrosis is uncommon and unpredictable. All caregivers should be counseled to expect dilatation to persist after obstruction is corrected.


Asunto(s)
Hidronefrosis , Pelvis Renal , Procedimientos de Cirugía Plástica/efectos adversos , Complicaciones Posoperatorias , Obstrucción Ureteral , Adolescente , Preescolar , Dilatación Patológica/diagnóstico , Dilatación Patológica/etiología , Femenino , Humanos , Hidronefrosis/diagnóstico , Hidronefrosis/etiología , Hidronefrosis/fisiopatología , Recién Nacido , Pelvis Renal/diagnóstico por imagen , Pelvis Renal/patología , Pelvis Renal/cirugía , Masculino , Evaluación de Procesos y Resultados en Atención de Salud , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/etiología , Pronóstico , Procedimientos de Cirugía Plástica/métodos , Estudios Retrospectivos , Estados Unidos , Obstrucción Ureteral/diagnóstico , Obstrucción Ureteral/etiología
6.
J Pediatr Surg ; 53(7): 1374-1380, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29258699

RESUMEN

PURPOSE: Localized vaginal rhabdomyosarcoma (RMS) is associated with a favorable prognosis, but strategies for local control remain controversial. The use of radiotherapy (RT) can have important long-term sequelae, while traditional resection involves major reconstructive surgery. We describe a new surgical approach employing a minimally-invasive resection and immediate reconstruction. MATERIALS AND METHODS: Records from 4 consecutive patients with localized vaginal RMS managed in 4 major pediatric referral centers were reviewed. All cases were performed with a standardized technique. RESULTS: Patients were diagnosed at a median age of 24months. Each underwent a total/subtotal vaginectomy with autologous buccal graft vaginal replacement. Final margins were focally positive in one patient and negative in three. None received radiotherapy. To date, all patients have patent buccal neovaginas, enjoy a favorable aesthetic result, and remain disease-free at a median follow-up of 35months. CONCLUSIONS: We report 4 cases of localized vaginal RMS successfully treated with a minimally invasive surgical approach. All patients have avoided radiation and remain disease-free. Our initial data suggest that surgical local control and immediate reconstruction are feasible and can spare these patients the long-term complications of RT. Longer follow-up is critical to ensure disease-free survival with a functional, successfully reconstructed neovagina. TYPE OF STUDY: Case series. LEVEL OF EVIDENCE: Level IV.


Asunto(s)
Procedimientos Quirúrgicos Ginecológicos/métodos , Mucosa Bucal/trasplante , Rabdomiosarcoma/cirugía , Vagina/cirugía , Neoplasias Vaginales/cirugía , Niño , Preescolar , Femenino , Humanos , Terapia Neoadyuvante/métodos , Resultado del Tratamiento
7.
Urology ; 113: 200-202, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29155187

RESUMEN

A baby boy was diagnosed with embryonal rhabdomyosarcoma causing left hydroureteronephrosis. A loop ureterostomy was performed, and the infant was treated per the RMS13 protocol. After 3 months of chemotherapy, the infant's tumor burden increased, and he underwent radical cystoprostatectomy and right-to-left transureteroureterostomy (end-to-end fashion utilizing the distal limb of his ureterostomy). This innovative method was utilized because the infant's tumor burden was too large to be treated effectively and safely with radiation. One year later, the infant has no evidence of disease. This demonstrates that optimal management of rhabdomyosarcoma is still unknown; therefore, each child warrants an individualized approach for optimal outcomes.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Prostatectomía/métodos , Neoplasias de la Próstata/diagnóstico por imagen , Neoplasias de la Próstata/terapia , Rabdomiosarcoma Embrionario/diagnóstico por imagen , Rabdomiosarcoma Embrionario/terapia , Ureterostomía/métodos , Quimioterapia Adyuvante , Progresión de la Enfermedad , Estudios de Seguimiento , Humanos , Hidronefrosis/diagnóstico , Hidronefrosis/etiología , Lactante , Masculino , Invasividad Neoplásica/patología , Estadificación de Neoplasias , Cuidados Posoperatorios/métodos , Neoplasias de la Próstata/patología , Rabdomiosarcoma Embrionario/patología , Medición de Riesgo , Insuficiencia del Tratamiento , Resultado del Tratamiento
8.
J Urol ; 198(5): 1159-1167, 2017 11.
Artículo en Inglés | MEDLINE | ID: mdl-28571679

RESUMEN

PURPOSE: A nonrefluxing megaureter is a relatively common cause of antenatal hydronephrosis. Although nonoperative management is favored, surgical intervention is sometimes warranted. However, there is controversy regarding the best approach, particularly in young children. We describe our experience with nondismembered side-to-side refluxing ureterocystotomy as a simple option to address obstruction. MATERIALS AND METHODS: Between January 2012 and January 2017, 32 patients underwent ureterocystotomy at 4 referral centers in North America. Demographics, surgical indications, complications, need for further interventions and change in hydronephrosis were captured. Patients were monitored clinically and with serial ultrasounds. RESULTS: Mean age at surgery was 3.7 months (range 0 to 33) and 25 (78%) patients were male. Unilateral procedures were performed in 29 patients. All patients were initially identified based on the presence of antenatal hydronephrosis and symptoms developed in 10. The procedure was conducted for primary nonrefluxing megaureter in 27 patients and to address secondary obstruction in the remainder. Mean followup was 34.3 months (range 6 to 58). At the most recent evaluation most children demonstrated significant improvement in dilation (86%). To date, 6 patients have undergone further procedures, including a circumcision and 2 ureteral reimplantations for recurrent infections. CONCLUSIONS: Our results suggest that side-to-side refluxing ureterocystotomy is a straightforward, minimally invasive alternative for the surgical management of nonrefluxing megaureter. Despite the trade-off of relieving obstruction and creating reflux, it can be considered a potentially definitive procedure in patients who remain infection-free, particularly circumcised boys. Extended followup with close monitoring is critical to document long-term results with this intervention.


Asunto(s)
Guías de Práctica Clínica como Asunto , Uréter/anomalías , Obstrucción Ureteral/cirugía , Ureterostomía/normas , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Pelvis Renal , Masculino , Estudios Retrospectivos , Resultado del Tratamiento , Ultrasonografía , Uréter/cirugía , Obstrucción Ureteral/congénito
9.
Can Urol Assoc J ; 9(7-8): E453-7, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26279715

RESUMEN

INTRODUCTION: Pediatric pyeloplasty with double J (DJ) stent drainage requires manipulation of the uretero-vesical junction (UVJ) and a second anesthetic for removal. Externalized uretero-pyelostomy (EUP) stents avoid these issues. We report outcomes of laparoscopic and open pyeloplasty with EUP compared to DJ stents in children. METHODS: We retrospectively reviewed 76 consecutive children who underwent pyeloplasty for ureteropelvic junction (UPJ) obstruction over a 1-year period by 5 pediatric urologists at a single institution. The exclusion criteria included patients with concomitant urological procedures, other urinary drainage strategies, "stentless" pyeloplasty or patients without follow-up data. Based on surgeon preference, 24 patients had a EUP stent and 38 had a DJ stent placed. RESULTS: The mean follow-up was 23.8 ± 10.9 months and 21.1 ± 11.1 months for the EUP and DJ stent groups, respectively (p = 0.32). The mean age was 40 ± 54 months and 80 ± 78 months for the EUP and DJ groups, respectively (p = 0.04). The EUP group had a greater proportion of open pyeloplasties (n = 17, 71%) versus the DJ group (n = 16, 42%; p = 0.04). There were no statistically significant differences in operative time, length of stay, and overall complication rate between groups. Complications were divided by timing of complication (intraoperative, before and after 3 months) and according to the Clavien Classification system. There were no statistically significant differences between these subgroups. The limitations of this study include small sample size, potential selection bias, and heterogeneity between both study groups. CONCLUSIONS: Pyeloplasty using EUP stents does not incur prolonged operative time, longer length of stay or higher complication rate when compared to DJ stents. Within the limitations of this study, EUP stents may be a safe alternative to DJ stents.

10.
J Pediatr Surg ; 50(10): 1776-82, 2015 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-26195452

RESUMEN

BACKGROUND/PURPOSE: Indirect expenses for accessing health care may place significant fiscal strain on Canadian families. Telemedicine alternatives, using email, telephone, and video conferencing, can mitigate such financial burdens by reducing travel and related costs. Our objectives were to assess costs that families incur visiting an outpatient pediatric surgical clinic, and family attitudes toward telemedicine alternatives. METHODS: A survey was offered pre-consult to all families who attended pediatric urology and general surgery outpatient clinics over a three-month period. RESULTS: A total of 1032 of 1574 families screened participated (66.0%). Less than half (18.5%) of participants traveled over 200 km, and 32.9% spent over 4 hours in transit, round-trip. The proportion of participants who spent over $50 on travel and ancillary expenses was 33.0%. In 74.0% of families, 1 or more adults missed work. The proportion of families who perceived costs as somewhat high or high was 29.1%. Perceived cost was positively correlated to distance traveled, money spent, and missed work (p<0.01). Most were comfortable with medical communication using technology; and 34.3%-42.7% would avoid an in-person clinic visit utilizing email, telephone, and video conferencing. Higher perceived cost (p<0.001) and distance traveled (p<0.01) were only weakly associated with greater willingness to substitute a clinic visit with video conferencing. CONCLUSIONS: Many families face high costs related to routine outpatient clinical visits, and there is a substantial willingness by them to access telemedicine alternatives, rather than the traditional face-to-face clinical visit.


Asunto(s)
Instituciones de Atención Ambulatoria/economía , Atención Ambulatoria/economía , Actitud Frente a la Salud , Familia , Accesibilidad a los Servicios de Salud/economía , Telemedicina , Adulto , Canadá , Niño , Femenino , Cirugía General , Gastos en Salud , Humanos , Masculino , Pediatría , Derivación y Consulta/economía , Encuestas y Cuestionarios , Viaje/economía , Urología
11.
J Urol ; 193(2): 632-6, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25219697

RESUMEN

PURPOSE: We examined the presentation, diagnosis and management of radiologically detected pediatric urachal anomalies and assessed the risk of malignant degeneration. MATERIALS AND METHODS: Our radiology database (2000 to 2012) was queried for all children younger than 18 years who were diagnosed with a urachal anomaly radiographically, and the operative database was used to determine those who underwent excision. Data collected included demographics, presenting symptoms, imaging modality and indication for excision. These data were compared to the Ontario Cancer Registry to determine the risk of malignancy. RESULTS: A total of 721 patients were radiographically diagnosed with a urachal anomaly (667 incidentally), yielding a prevalence of 1.03% of the general pediatric population. Diagnoses were urachal remnants (89% of cases), urachal cysts (9%) and patent urachus (1.5%). Ultrasonography was the most common imaging modality (92% of cases), followed by fluoroscopy/voiding cystourethrography (5%) and computerized tomography/magnetic resonance imaging (3%). A total of 61 patients (8.3%) underwent surgical excision. Indications for imaging and treatment were umbilical drainage (43% of patients), abdominal pain (28%), palpable mass (25%) and urinary tract infection (7%). Mean age at excision was 5.6 years and 64% of the patients were male. Based on provincial data, the number needed to be excised to prevent a single case of urachal adenocarcinoma was 5,721. CONCLUSIONS: Urachal anomalies are more common than previously reported. Children with asymptomatic lesions do not appear to benefit from prophylactic excision, as the risk of malignancy later in life is remote and a large number of urachal anomalies would need to be removed to prevent a single case of urachal adenocarcinoma.


Asunto(s)
Adenocarcinoma/epidemiología , Uraco/anomalías , Neoplasias de la Vejiga Urinaria/epidemiología , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Pronóstico , Medición de Riesgo
12.
Ther Adv Urol ; 6(4): 165-76, 2014 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25083165

RESUMEN

Advances in the management of Wilms' tumor have been dramatic over the past half century, not in small part due to the institution of multimodal therapy and the formation of collaborative study groups. While different opinions exist in the management of Wilms' tumors depending on where one lives and practices, survival rates have surpassed 90% across the board in Western societies. With more children surviving into adulthood, the concerns about morbidity have reached the forefront and now represent as much a consideration as oncologic outcomes these days. Innovations in treatment are on the horizon in the form of potential tumor markers, molecular biological means of testing for chemotherapeutic responsiveness, and advances in the delivery of chemotherapy for recurrent or recalcitrant tumors. Other technological innovations are being applied to childhood renal tumors, such as minimally invasive and nephron-sparing approaches. Risk stratification also allows for children to forego potentially unnecessary treatments and their associated morbidities. Wilms' tumor stands as a great example of the gains that can be made through protocol-driven therapy with strenuous outcomes analyses. These gains continue to spark interest in minimization of morbidity, while avoiding any compromise in oncologic efficacy. While excitement and innovation are important in the advancement of treatment delivery, we must continue to temper this enthusiasm and carefully evaluate options in order to continue to provide the highest standard of care in the management of this now highly curable disease.

13.
Curr Urol Rep ; 15(8): 426, 2014 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-24903352

RESUMEN

Botulinum toxin A's (Onabotulinum toxin A - OnabotA) utility in the pediatric population is evolving, and is currently being used in the treatment of lower urinary tract dysfunction, both in children with neuropathic compromise, and non-neuropathic overactive bladders. The results of having OnabotA injected directly into the bladder wall cystoscopically are: a more compliant bladder with reduced bladder pressure, avoiding renal compromise and upper urinary tract deterioration; increased bladder capacity; and the ability for children to reach an improved degree of urinary continence through a minimally invasive approach. A growing body of research in patients with either neuropathic bladders or overactive bladders (OAB), have shown excellent results when looking at urodynamic parameters, patient satisfaction and improvement in symptomatology. One of the main indications for the use of OnabotA in children with neuropathic bladders is to delay or avoid the need for augmentation cystoplasty. By achieving the aforementioned results, some children can delay or avoid this more invasive and permanent procedure. Prospective studies are needed to answer questions regarding optimal dosage and frequency, ideal patient selection criteria and assessment of long-term outcomes and complications.


Asunto(s)
Inhibidores de la Liberación de Acetilcolina/administración & dosificación , Toxinas Botulínicas Tipo A/administración & dosificación , Síntomas del Sistema Urinario Inferior/tratamiento farmacológico , Vejiga Urinaria Neurogénica/tratamiento farmacológico , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Niño , Humanos , Inyecciones , Estudios Prospectivos
14.
J Pediatr Urol ; 10(4): 753-7, 2014 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-24477421

RESUMEN

OBJECTIVE: Oxybutynin is the current gold standard drug for management of overactive bladder (OAB) in children, but can have significant side effects or be difficult to administer in multiple daily doses. Herein, we report our experience with transdermal oxybutynin patch (TOP) as an alternative in a selected patient population without neuropathic compromise. MATERIALS AND METHODS: Consecutive patients assessed in a pediatric urology clinic over a 1-year period, diagnosed with OAB with minimum follow-up of 3 months, were included. TOP starting dose was 3.9 mg/day based on product design (Oxytrol). Demographics and outcomes data were retrospectively collected. Symptomatic response was defined as improvement or resolution of lower urinary tract symptoms. RESULTS: 35 children met inclusion criteria (mean age 8 years, range 4-16). Overall, 97% reported good symptom response. The main side effect was skin irritation at TOP site (35%), leading to discontinuation in 20%. There were no reports of other significant side effects. Mean bladder capacity increased from 104 ml to 148 ml at follow-up. CONCLUSIONS: Our data suggest that TOP is a viable alternative for children with non-neuropathic OAB who do not tolerate other formulations of oxybutynin. These findings highlight the potential benefit of transdermal drug delivery in the pediatric setting.


Asunto(s)
Ácidos Mandélicos/administración & dosificación , Antagonistas Muscarínicos/administración & dosificación , Vejiga Urinaria Hiperactiva/tratamiento farmacológico , Administración Cutánea , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Ácidos Mandélicos/efectos adversos , Antagonistas Muscarínicos/efectos adversos , Estudios Retrospectivos , Parche Transdérmico , Resultado del Tratamiento , Vejiga Urinaria Hiperactiva/etiología
15.
Urology ; 81(5): 1010-5, 2013 May.
Artículo en Inglés | MEDLINE | ID: mdl-23490521

RESUMEN

OBJECTIVE: To evaluate the incidence of hip fracture in men with prostate cancer receiving androgen deprivation therapy (ADT). MATERIALS AND METHODS: One of the detrimental side effects of ADT for prostate cancer is osteoporosis. Through an osteoporosis prevention program implemented in our healthcare system, the patients at risk undergo dual x-ray absorptiometry scans and receive treatment if the T-score indicates bone loss. We evaluated the incidence of hip fracture in men with prostate cancer who were receiving ADT through a retrospective, cohort study conducted within a managed care organization. The participants were all men newly diagnosed with prostate cancer from January 2003 to December 2007 receiving leuprolide injections. Patients who had had a dual x-ray absorptiometry scan beginning 3 months before the index date through the end of study were included in the intervention group; all others were included in the comparison group. The main outcome of interest was a hip fracture occurring after the index date, excluding cancer pathologic fractures, traumatic fractures, and fractures associated with epilepsy. RESULTS: A total of 1071 patients were in the intervention group, and 411 were in the comparison group. In the intervention group, 18 hip fractures occurred compared with 17 in the comparison group. The incidence rate of hip fractures per 1000 person-years was 5.1 (95% confidence interval 3.0-8.0) in the intervention group and 18.1 (95% confidence interval 10.5-29.0) in the comparison group. CONCLUSION: The incidence rate of hip fracture in this population was reduced >70% with enrollment in an osteoporosis management system, avoiding this morbid complication of ADT.


Asunto(s)
Antagonistas de Andrógenos/uso terapéutico , Antineoplásicos Hormonales/uso terapéutico , Fracturas de Cadera/prevención & control , Osteoporosis/prevención & control , Neoplasias de la Próstata/tratamiento farmacológico , Anciano , Densidad Ósea , California/epidemiología , Estudios de Seguimiento , Fracturas de Cadera/epidemiología , Fracturas de Cadera/etiología , Humanos , Incidencia , Masculino , Osteoporosis/complicaciones , Osteoporosis/epidemiología , Neoplasias de la Próstata/complicaciones , Estudios Retrospectivos
16.
J Urol ; 185(5): 1698-703, 2011 May.
Artículo en Inglés | MEDLINE | ID: mdl-21419446

RESUMEN

PURPOSE: We determined the incidence of urinary tract cancer in patients with hematuria, stratified risk by age, gender and hematuria degree, and examined current best policy recommendations. MATERIALS AND METHODS: We performed a large, retrospective population based cohort study of patients who underwent microscopic urinalysis during 2004 and 2005 in a large managed care organization. Patients were followed for 3 years for urinary tract cancer. RESULTS: We identified 772,002 patients who underwent urinalysis during the study period. After exclusions due to previous hematuria, age less than 18 years, pregnancy, urinary tract infection, inpatient status and prior urinary tract cancer 309,402 patients were available for analysis, of whom 156,691 had hematuria. The overall 3-year incidence of urinary tract cancer in those with hematuria was 0.68%. Older age (greater than 40 years OR 17.0, 95% CI 11.2-25.7), greater hematuria (greater than 25 red blood cells per high power field OR 4.0, 95% CI 3.5-4.5) and male gender (OR 4.8, 95% CI 4.2-5.6) were associated with a higher risk of cancer. The American Urological Association definition of microhematuria had 50% sensitivity, 84% specificity and 1.3% positive predictive value. CONCLUSIONS: The incidence of urinary tract cancer is low even in individuals with microhematuria. Thus, current best policy recommendations do not perform well. Since older age, male gender and greater hematuria are associated with a higher risk of cancer, future studies should evaluate strategies that target these populations.


Asunto(s)
Hematuria/diagnóstico , Neoplasias Urológicas/diagnóstico , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , California/epidemiología , Femenino , Humanos , Incidencia , Modelos Logísticos , Masculino , Persona de Mediana Edad , Distribución de Poisson , Sistema de Registros , Estudios Retrospectivos , Riesgo , Programa de VERF , Sensibilidad y Especificidad , Factores Sexuales , Urinálisis , Neoplasias Urológicas/epidemiología
17.
J Urol ; 185(4): 1388-93, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21334642

RESUMEN

PURPOSE: Previous data suggest a potential relationship between inflammation and erectile dysfunction. If it is causal, nonsteroidal anti-inflammatory drug use should be inversely associated with erectile dysfunction. To this end we examined the association between nonsteroidal anti-inflammatory drug use and erectile dysfunction in a large, ethnically diverse cohort of men enrolled in the California Men's Health Study. MATERIALS AND METHODS: This prospective cohort study enrolled male members of the Kaiser Permanente managed care plans who were 45 to 69 years old beginning in 2002. Erectile dysfunction was assessed by questionnaire. Nonsteroidal anti-inflammatory drug exposure was determined by automated pharmacy data and self-reported use. RESULTS: Of the 80,966 men in this study 47.4% were considered nonsteroidal anti-inflammatory drug users based on the definitions used and 29.3% reported moderate or severe erectile dysfunction. Nonsteroidal anti-inflammatory drug use and erectile dysfunction strongly correlated with age with regular drug use increasing from 34.5% in men at ages 45 to 49 years to 54.7% in men 60 to 69 years old with erectile dysfunction increasing from 13% to 42%. The unadjusted OR for the association of nonsteroidal anti-inflammatory drugs and erectile dysfunction was 2.40 (95% CI 2.27, 2.53). With adjustment for age, race/ethnicity, smoking status, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, coronary artery disease and body mass index, a positive association persisted (adjusted OR 1.38). The association persisted when using a stricter definition of nonsteroidal anti-inflammatory drug exposure. CONCLUSIONS: These data suggest that regular nonsteroidal anti-inflammatory drug use is associated with erectile dysfunction beyond what would be expected due to age and comorbidity.


Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Disfunción Eréctil/inducido químicamente , Anciano , Antiinflamatorios no Esteroideos/administración & dosificación , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Encuestas y Cuestionarios
18.
J Pediatr Surg ; 46(1): 217-20, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21238671

RESUMEN

BACKGROUND/PURPOSE: This study evaluated the optimal timing for repair, incarceration risk, and postoperative apnea rate in premature infants with inguinal hernias. METHODS: This was a retrospective review of premature infants undergoing inguinal hernia repairs from 2006 to 2008. RESULTS: One hundred seventy-two patients were identified. Mean gestational age was 30.7 weeks, and mean birth weight was 1428 g. At repair, mean postconceptional age was 46.6 weeks with mean weight of 3688 g. Elective repairs were performed on 127 patients. Thirty-five patients were discharged with a known hernia, and none developed incarceration. No postoperative apnea episodes occurred in any of these 127 patients. Forty-five patients had herniorrhaphy before discharge from the neonatal intensive care unit (NICU) with a median postoperative hospitalization of 8 days (2-51 days). Thirteen percent required prolonged (>48 hours) intubation after repair. Of 172 patients, 8 (4.6%) developed incarcerated hernia. Five incarcerations occurred in the NICU before discharge, and 3 patients had incarceration as their initial presentation. CONCLUSIONS: There is minimal risk of postoperative apnea for premature infants undergoing elective inguinal hernia repair. The risk of incarceration in premature infants discharged from the NICU with a known hernia is low. Herniorrhaphy before discharge from the NICU was associated with a prolonged hospital stay.


Asunto(s)
Apnea/epidemiología , Hernia Inguinal/cirugía , Enfermedades del Prematuro/cirugía , Complicaciones Posoperatorias/epidemiología , Peso al Nacer , Comorbilidad , Procedimientos Quirúrgicos Electivos/métodos , Femenino , Cirugía General/métodos , Edad Gestacional , Hernia Inguinal/epidemiología , Humanos , Recién Nacido , Enfermedades del Prematuro/epidemiología , Tiempo de Internación , Masculino , Pediatría/métodos , Estudios Retrospectivos , Factores de Tiempo , Resultado del Tratamiento
19.
J Urol ; 178(5): 2098-101; discussion 2102, 2007 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-17869288

RESUMEN

PURPOSE: To establish the repair patterns of flexible cystoscopes we performed a systematic review of repairs performed at an independent endoscope repair company. MATERIALS AND METHODS: Repair and cost data for 2000 to 2004 were obtained from an independent endoscope repair company. All cystoscopes underwent a detailed inspection using a preset protocol and the frequency of individual repair descriptions was extracted from a computer database. RESULTS: A total of 1,150 repairs were performed on the Olympus CYF (3%), CYF-2 (21%), CYF-3 (56%) and CYF-4 (20%) flexible cystoscopes. Repairs to the distal tip (28% of all repairs) most commonly involved the bending rubber or outer polymer sheath. Repairs to the hand control segment (14% of all repairs) most commonly involved the ocular. Repairs for image (14% of all repairs) and deflection (9%) were most commonly performed on the fiberoptic bundle and wires, respectively. Repairs to the deflection apparatus comprised a significantly greater proportion of total repairs in the early CYF models than in the CYF-4 model (10% to 12% vs 3%, p <0.01, chi-square 10.73). Less than 1% of all cystoscopes needed more than 2 repairs. CONCLUSIONS: Olympus cystoscopes require repair every 2 to 3 years and they appear to be durable. The distal deflection tip, specifically the outer bending rubber, is the most common site of flexible cystoscope damage. Although it appears that significant improvements have been made to the deflection apparatus, the number of repairs to other areas has not changed significantly with time. Improvements in form and function of the distal tip, the hand control segment and the fiberoptic bundles may enhance the durability of flexible cystoscopes.


Asunto(s)
Cistoscopios/economía , Costos y Análisis de Costo , Diseño de Equipo , Falla de Equipo/economía , Equipo Reutilizado/economía , Tecnología de Fibra Óptica , Humanos , Docilidad , Estudios Retrospectivos
20.
Urology ; 70(1): 11-5, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17656198

RESUMEN

OBJECTIVES: To conduct a systematic review of repairs of Olympus flexible ureteroscopes using an independent database to compare and contrast with the published data obtained from ureteroscope manufacturers. METHODS: The repair data from 2000 to 2004 were extracted from a computer database obtained through Precision Endoscopy of America, an independent endoscope repair company. All endoscopes submitted for repair underwent a detailed 16 to 32-point inspection using a set protocol for each endoscope make and model, as determined by the manufacturer. RESULTS: A total of 341 repairs were performed on the Olympus URF-P (4%), URF-P2 (47%), and URF-P3 (47%) flexible ureteroscopes. The distal segment was the most common repair site requiring repair (30%), with 87% of these repairs requiring replacement of the bending rubber. The repairs also included the deflection apparatus (14%) and hand control segment (9%) and image-related repairs (9%). The between-group assessment showed a statistically significant decrease in deflection apparatus repairs for the URF-P2 (20%) compared with the URF-P3 (7%; P <0.001, chi-square = 11.96). CONCLUSIONS: The results of our study have shown that the loss of deflection is less common with the newer Olympus ureteroscopes. The distal deflection tip, specifically the outer bending rubber, is the most common site of damage to Olympus flexible ureteroscopes. Improvements in form and function of the distal tip should decrease the maintenance expenses and increase ureteroscope longevity.


Asunto(s)
Ureteroscopios , Diseño de Equipo , Estudios Retrospectivos
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