1.
RSC Adv
; 9(65): 37901-37905, 2019 Nov 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35541773
RESUMEN
Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis. The 3-aryl- and 3-heteroaryl-substituted acids are stable during prolonged storage, exhibit antibacterial activity against ESKAPE pathogens and show a low level of cytotoxicity.