Oxygen-binding properties of blood in insulin resistance with different asprosin content.

The oxygen-binding properties of blood were studied in male patients with insulin resistance (IR) with different levels of asprosin. The content of asprosin, parameters of blood oxygen transport function, as well as gas transmitters, nitrogen monoxide and hydrogen sulfide, were determined in the venous blood plasma. In the studied IR patients with increased blood asprosin content, impaired blood oxygenation was noted; IR patients with normal body weight had increased hemoglobin affinity for oxygen, while in IR patients with overweight and the 1st degree obesity, this parameter decreased. The detected increase in the concentration of nitrogen monoxide and the decrease in hydrogen sulfide may be important for the oxygen-binding properties of the blood and the development of metabolic imbalance.

[Effect of simvastatin on the oxygen transport function and prooxidant - antioxidant balance in blood].

The effects of simvastatin on the blood oxygen transport function and indices of prooxidant - antioxidant balance at incubation have been studied. Simvastatin at a concentration of 100 ng/ml increases p50 (the blood pO2 corresponding to its 50% oxygen saturation) at real values of pH and pCO2 from 39.53 + 2.41 (p <0.05) to 36.60 (36, 40, 37, 60) (p <0.05) mm Hg. An increase in the drug concentration led to a decrease in the level of this parameter, but in a dose-independent manner. In addition, the level of nitrates/nitrites in the blood plasma was also increased, which was evidence of increasing activity of the L-arginine-NO system. The indices of prooxidant - antioxidant balance exhibited no significant changes. The results demonstrate a new pleiotropic effect of simvastatin, which is realized via a change in the hemoglobin - oxygen affinity through modification of NO production. This effect must be taken into account in the treatment of pathology in the blood circulation.

[Oxygen-binding capacities of hemoglobin and nitric oxide].

The analysis of the literature and our own results indicates that a nitric oxide carries out a role the allosteric effector of hemoglobin, changing its affinity to oxygen and defining a condition of oxygen transport blood function. It is important point for modification of functional properties of hemoglobin and its participation in the flow of oxygen in tissues, which plays an important role in development of disadaption reactions at stress and decreased bioactivity of the nitric oxide at the endothelial dysfunction. These findings give possiblity to creat the new ways to correct hypoxical conditions through influence on oxygen-binding properties of the blood and activity of L-arginin-NO system.