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1.
J Am Chem Soc ; 123(43): 10684-90, 2001 Oct 31.
Artículo en Inglés | MEDLINE | ID: mdl-11674000

RESUMEN

The ionic partition diagram methodology has been generalized to address both hydrophilic and lipophilic compounds and to consider biphasic systems with variable phase volume ratios. With this generalized approach electrochemical measurements of ion transfer potentials afford the determination of the standard partition coefficients of all forms of ionizable molecules, including the neutral form, as well as the evaluation of the dissociation constant of monoprotic substances. An interesting consequence of this approach is the definition of an extraction pK(a,ext) which is the apparent pK(a) of neutral acids and bases when dissolved in the organic phase.


Asunto(s)
Lípidos/química , Solubilidad , 2,4-Dinitrofenol/química , Ácidos/química , Compuestos de Anilina/química , Electroquímica , Concentración de Iones de Hidrógeno , Iones/química , Cinética , Termodinámica , Agua/química
2.
Pharm Res ; 18(5): 702-8, 2001 May.
Artículo en Inglés | MEDLINE | ID: mdl-11465429

RESUMEN

PURPOSE: This work examines whether ion-pairing contributes to the apparent lipophilicity of cations, which is seen by a shake-flask or titrimetic method to be influenced by the nature and concentration of counter-ions. METHODS: To solve this problem, the lipophilicity of several quaternary ammonium drugs was measured by cyclic voltammetry in the 1,2-dichloroethane/water system. The standard ionic partition coefficient values so obtained (log Pdce(o,C)) were correlated with log Poct values calculated by the CLOGP algorithm for the respective neutral molecules. RESULTS: The standard (i.e., intrinsic) lipophilicity values are shown to depend on a, the structure of the ion (nature, volume, charge), and b, on the Galvani potential difference at the ITIES (interface between two immiscible electrolyte solutions). CONCLUSIONS: The standard lipophilicity values were not influenced by counter-ions. In contrast, simulations showed that the increased apparent lipophilicity of cations, as measured by the shake-flask method in the presence of lipophilic anions, is fully accounted for by the resulting increase in the Galvani potential difference.


Asunto(s)
Compuestos de Amonio Cuaternario/química , Fenómenos Químicos , Química Física , Electroquímica , Dicloruros de Etileno/química , Indicadores y Reactivos , Lípidos/química , Agua/química
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