RESUMEN
ABSTRACT Peripheral odontogenic fibroma (POF) is a rare benign neoplasm of odontogenic mesenchymal origin that accounts for approximately 4.7% of all odontogenic tumors. This article reports the case of a 29-year-old woman who presented with a painless, reddish mass in the right vestibular mandibular gingiva between the second premolar and the first molar. Radiographic examination revealed small crestal bone loss in the region. Microscopic analysis revealed a tumor composed of cellular fibroblastic connective tissue intermingled with conspicuous islands and strands of apparently inactive odontogenic epithelium. The final diagnosis was POF. No clinical signs of recurrence were observed 22 months after surgical excision. POF may be clinically mistaken for other common gingival lesions, such as pyogenic granuloma, peripheral giant cell lesion, and peripheral ossifying fibroma. Conservative local excision has been suggested as the treatment of choice for POF. However, in view of the paucity of information on the biological behavior and recurrence rate of this tumor, long-term follow-up of patients is mandatory.
RESUMEN El fibroma odontogénico periférico (FOP) es una neoplasia benigna rara de origen mesenquimatosa dental, que representa aproximadamente el 4,7% de todos los tumores odontogénicos. Este reporte describe el caso de una mujer de 29 años de edad que se presentó con un nódulo rojizo indoloro en la encía mandibular vestibular derecha, entre el segundo premolar y el primer molar. El examen radiográfico reveló una pequeña pérdida de tejido óseo en la región de la cresta alveolar. El análisis microscópico mostró un tumor compuesto de tejido conjuntivo fibroso celular entremezclado con visibles islotes y filamentos de epitelio odontógeno aparentemente inactivo. El diagnóstico final fue FOP. No se observó recurrencia de la lesión después de 22 meses de la cirugía. El FOP puede ser clínicamente confundido con otras lesiones gingivales comunes, como granuloma piogénico, lesión periférica de células gigantes y fibroma osificante periférico. Escisión local conservadora ha sido recomendada como tratamiento de elección para FOP. Sin embargo, teniendo en cuenta la escasez de informaciones sobre el comportamiento biológico y la tasa de recidiva de este tumor, el seguimiento a largo plazo de los pacientes es fundamental.
RESUMO Fibroma odontogênico periférico (FOP) é uma neoplasia benigna rara, de origem mesenquimal odontogênica, representando aproximadamente 4,7% de todos os tumores odontogênicos. Este artigo relata o caso de uma mulher de 29 anos de idade que se apresentou com um nódulo avermelhado, indolor, na gengiva mandibular vestibular direita, entre o segundo pré-molar e o primeiro molar. O exame radiográfico revelou uma pequena perda óssea na região da crista alveolar. A análise microscópica evidenciou um tumor composto de tecido conjuntivo fibroso celularizado, entremeado por conspícuas ilhas e cordões de epitélio odontogênico aparentemente inativo. O diagnóstico final foi de FOP. Nenhum sinal clínico de recorrência foi observado 22 meses após a excisão cirúrgica. O FOP pode ser clinicamente confundido com outras lesões gengivais comuns, como granuloma piogênico, lesão periférica de células gigantes e fibroma ossificante periférico. A excisão local conservadora tem sido sugerida como tratamento de escolha para o FOP. No entanto, tendo em vista a escassez de informações sobre o comportamento biológico e a taxa de recorrência desse tumor, o acompanhamento dos pacientes a longo prazo é mandatório.
RESUMEN
The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grade of malignancy). Clinical data were obtained from the patient records. The histological grading system of malignancy proposed by Bryne (1998) [9] was used for the analysis of morphological parameters. The results were analyzed statistically by χ(2) test (p < 0.05). Galectin-1 expression was observed in 87.7% of cases and was significantly correlated with metastasis (p = 0.033) and clinical stage (p = 0.016). Immunoexpression of galectin-3 was observed in 87.7% of cases and was correlated with the presence of metastasis (p = 0.033) and histological grade of malignancy (p = 0.031). Galectin-4 showed no significant correlation with any of the parameters studied. Expression of galectin-7 was observed in 73.8% of cases and was significantly correlated with the histological grade of malignancy (p = 0.005). In conclusion, the intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue.