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J Neurol Neurosurg Psychiatry ; 81(4): 423-7, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19965856

RESUMEN

Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.


Asunto(s)
Fenómenos Biomecánicos/efectos de los fármacos , Fenómenos Biomecánicos/fisiología , Toxinas Botulínicas Tipo A/farmacocinética , Toxinas Botulínicas Tipo A/uso terapéutico , Fármacos Neuromusculares/farmacocinética , Fármacos Neuromusculares/uso terapéutico , Espasmo , Accidente Cerebrovascular/complicaciones , Extremidad Superior/fisiopatología , Toxinas Botulínicas Tipo A/administración & dosificación , Femenino , Humanos , Inyecciones Intramusculares , Masculino , Persona de Mediana Edad , Fármacos Neuromusculares/administración & dosificación , Espasmo/tratamiento farmacológico , Espasmo/etiología , Espasmo/fisiopatología
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