RESUMEN
INTRODUCTION AND IMPORTANCE: Neuroendocrine tumors most frequently originate from the gastrointestinal tract (GIT). Their presentation in tissues other than the GIT and pancreas is usually due to metastatic involvement from lesions at these sites. There have been a few cases of neuroendocrine tumors identified in tissues such as the mesentery and peritoneum, without identification of a primary lesion supporting their origin as metastasis. CASE PRESENTATION: We present the case of a patient with abdominal pain, in whom a primary mesenteric neuroendocrine tumor was identified. The patient completed one year of follow-up without identification of an additional lesion. Case Reported in line with the SCARE criteria. CLINICAL DISCUSSION: This is a rare condition with few reports in the literature, without significant changes in its classification or management. CONCLUSION: The search for a primary lesion and follow-up are essential to characterize the presence of primary mesenteric neuroendocrine tumors.