Mirror Instabilities in the Inner Magnetosphere and Their Potential for Localized ULF Wave Generation.

Results from the NASA Van Allen Probes mission indicate extensive observations of mirror/drift-mirror (M/D-M hereafter) unstable plasma regions in the night-side inner magnetosphere. Said plasmas lie on the threshold between the kinetic and frozen-in plasma regimes and have favorable conditions for the formation of M/D-M modes and subsequent ultralow frequency (ULF) wave signatures in the surrounding plasma. We present the results of a climatological analysis of plasma-γ (anisotropy measure) and total plasma-ß (ratio of particle to magnetic field pressure) in regard to the satisfaction of instability conditions on said M/D-M modes under bi-Maxwellian distribution assumption, and ascertain the most likely region for such plasmas to occur. Our results indicate a strong preference for the premidnight sector of the night-side magnetosphere, with events ranging in time scales from half a minute (roughly 200 km in scale size) to several hours (multiple Earth radii). The statistical distribution of these plasma regions explicitly identifies the source region of "storm time Pc5 ULF waves" and suggests an alternative mechanism for their generation in the night-side inner magnetosphere.

Hypercoagulability in dogs with protein-losing enteropathy.

BACKGROUND: Dogs with protein-losing enteropathy (PLE) have previously been reported to present with thromboembolism; however, the prevalence and pathogenesis of hypercoagulability in dogs with PLE have not been investigated so far. HYPOTHESIS: Dogs with PLE are hypercoagulable compared with healthy control dogs. ANIMALS: Fifteen dogs with PLE. Thirty healthy dogs served as controls (HC). METHODS: A prospective study was performed including 15 dogs with PLE. All dogs were scored using the canine chronic enteropathy activity index (CCECAI). Thromboelastography (TEG) and other measures of coagulation were evaluated. Recalcified, unactivated TEG was performed and reaction time (R), kinetic time (K), alpha angle (α), and maximum amplitude (M(A)) values were recorded. Nine dogs were reassessed after initiation of immunosuppressive treatment. RESULTS: All dogs with PLE in the study were hypercoagulable with decreased R (PLE: median 7.8, range [2.4-11.2]; HC: 14.1 [9.1-20.3]), decreased K (PLE: 2.5 [0.8-5.2]; HC: 8.25 [4.3-13.1]), increased α (PLE: 56.7 [38.5-78.3]; HC: 25.6 [17-42.4]), and increased M(A) (PLE: 68.2 [54.1-76.7]; HC: 44.1, [33.5-49]) (all P < .001). Median antithrombin (AT) concentration was borderline low in PLE dogs; however, mean serum albumin concentration was severely decreased (mean 1.67 g/dL ± 5.1, reference range 2.8-3.5 g/dL). Despite a significant improvement in serum albumin and CCECAI, all 9 dogs with PLE were hypercoagulable at re-examination. CONCLUSIONS AND CLINICAL IMPORTANCE: The hypercoagulable state in dogs with PLE cannot be solely attributed to loss of AT. Despite good clinical response to treatment, dogs remained hypercoagulable and could therefore be predisposed to thromboembolic complications.