Revolutionizing transdermal drug delivery: unveiling the potential of cubosomes and ethosomes.

The area of drug delivery systems has witnessed significant advancements in recent years, with a particular focus on improving efficacy, stability, and patient compliance. Transdermal drug delivery offers numerous benefits compared to conventional methods of drug administration through the skin. It helps in avoiding gastric irritation, hepatic first-pass metabolism, and gastric degradation of the drug. It bypasses the gastrointestinal tract, eliminating the risk of first-pass metabolism and allowing drugs to be administered without being affected by pH, enzymes, or intestinal bacteria. Additionally, it allows for sustained release of the drug, is noninvasive, and enhances patient adherence to the treatment regimen. The transdermal drug delivery system (TDDS) can serve as an alternative route for drug administration in individuals who cannot tolerate oral medications, experience nausea, or are unconscious. When compared to intravenous, hypodermic, and other parenteral routes, TDDS stands out due to its ability to eliminate pain, reduce the risk of infection, and prevent disease transmission associated with needle reuse. Consequently, the overall patient compliance is significantly improved with the utilization of TDDS. Among the noteworthy developments are cubosomes and ethosomes, two distinct yet promising carriers that have garnered attention for their unique properties. In conclusion, this review synthesizes the current knowledge on cubosomes and ethosomes, shedding light on their individual strengths and potential synergies. The exploration of their application in various therapeutic areas underscores their versatility and establishes them as key players in the evolving landscape of drug delivery systems.

Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology.

A poorly water soluble polar and non-polar bioactive complexes encapsulated in a nanocellulose-based polymeric network are the focus of this research. Ascorbic acid, resveratrol, holy basil extract, pomegranate extract, and niacin are all microencapsulated bioactive complexes that make up Zetalife®, a nutritional ingredient. It uses an interpenetrating polymeric network (IPN) with more dispersed nanocellulose and phospholipids to increase Zetalife® s bioavailability. Field Emission Scanning Electron Microscopic (FESEM) images were used in studying the morphology of encapsulated bioactive molecules. The average microbead size was determined to be 244.2 nm. After each month of storage, the sample's microbial content was measured to assess stability. In vitro release followed a first-order kinetic model with high R2.

Systematic review on activity of liposomal encapsulated antioxidant, antibiotics, and antiviral agents.

Reactive oxygen species (ROS) like superoxide anion, hydrogen peroxide, and hydroxyl radical, can be formed as normal products of aerobic metabolism. Overproduction or insufficient removal of ROS results in significant damage to cell structure and functions. Antioxidants applied directly and at relatively high concentrations to cellular systems are effective in protection against the damaging actions of ROS. Microorganisms including Gram-positive and negative bacteria, fungi, protozoa, algae, etc., can be disease causing microorganism. Antimicrobial agents have the capability to inhibitor destroy the microorganisms. The problems arising from the use of antioxidant and antimicrobial agents include poor solubility, instability during storage, low bioavailability, and difficulty to reach target organs with sufficient doses. Liposomal antimicrobial agent and liposomal antioxidants enhance the solubility, bioavailability, and stability of antimicrobial agent and antioxidants.

Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability.

The aim of this study was to evaluate the oral bioavailability of liposomal vitamin C and non-liposomal vitamin C in healthy, adult, human subjects under fasting conditions through an open label, randomized, single-dose, two-treatment, two-sequence, two-period, two-way crossover, study. The vitamin C loaded liposome was well characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential measurements for evaluating morphology, particle size and stabilities, respectively. Microscopic image shows the core-type structure that confirms the characteristic pattern of liposome. The encapsulation efficiency (EE%) and the particle size were 65.85 ± 1.84% and below 100 nm, respectively. The results of the clinical studies of liposomal vitamin C by oral delivery to be 1.77 times more bioavailable than non-liposomal vitamin C. The liposomal vitamin C demonstrated higher values of Cmax, AUC0-t and AUC0-∞ related to non-liposomal vitamin C due to liposomal encapsulation. No adverse events were reported. It could be concluded that liposomal encapsulated ascorbic acid (vitamin C) shows well-organized morphological pattern, uniform particle size and highly efficient, which leads to have enhanced bioavailability.

Thermal, biodegradation and theoretical perspectives on nanoscale confinement in starch/cellulose nanocomposite modified via green crosslinker.

In this research work, we propose a synergistic effect of a green crosslinker and cellulose nanomaterial on the crystallinity, viscoelastic, and thermal properties of starch nanocomposites. A disaccharide derivative was used as a bio crosslinker and nanofiber from pineapple leaf as a reinforcing phase for starch. Sucrose was oxidised using periodate, that can selectively oxidise the vicinal hydroxyl group of sucrose and form tetra aldehyde derivative. Crystallinity of films after crosslinking decreased with successive addition of crosslinker. The melting temperature of films increased because of formation of more dense structure after crosslinking. Morphological investigations were analysed by atomic force microscopy. Polymer chain confinement and mechanics were quantified. The crosslink densities of the films were calculated using two models, phantom model and affine model, using storage modulus data. By using very low amount of crosslinker and nanoreinforcement, the properties of thermoplastic starch were significantly improved.

Chitin nanowhisker - Inspired electrospun PVDF membrane for enhanced oil-water separation.

The requirement of promoting a revolution in filtration technology has led to growing devotion in advanced functional materials such as electrospun membranes for filtering devices as a solution for providing water at lower energy costs. In this study, electrospun polyvinylidene fluoride membranes were fabricated by reinforcing 0.5 and 1 wt. % of chitin nanowhiskers in order to improve their thermal stability, mechanical properties, pure water flux and oil-water filtration performance for the possible application as filtration membranes. Morphological analysis revealed the porous and fibrous structure of membranes which confirmed by BET surface area analysis. Incorporation of chitin nanowhiskers improved the mechanical properties of the membranes such as elongation at break and tensile strength (specifically at 1 wt. % of chitin nanowhisker) while resulted in substantial enhancement of their thermal properties. Furthermore, polyvinylidene fluoride/chitin nanowhisker membranes showed enhanced oil-water separation ability, while reinforcement of chitin nanowhisker led to increase pure water flux rate, which measured as a crucial point in filtration membranes. The oil-water separation results compared with a commercial polyvinylidene fluoride membrane and the results signified the potential of electrospun polyvinylidene fluoride/chitin nanowhisker to be used for filtration application.

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review.

In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

Chitin nanowhisker (ChNW)-functionalized electrospun PVDF membrane for enhanced removal of Indigo carmine.

In this study, an active functional adsorbent membrane developed by combining both hydrophilic bio polymer filler such as chitin nanowhiskers (ChNW) which contains two functional groups and a hydrophobic polymer matrix such as polyvinylidene fluoride (PVDF) using electrospinning technique. Here ChNW were successfully extracted by excluding proteins and mineral and well characterized using FTIR, XRD, SEM and TEM. The optimized combination of PVDF/ChNW (15%:1%) membrane was fabricated and well characterized using SEM, water contact angle and FTIR spectroscopy. There was a remarkable difference in contact angle observed for PVDF/ChNW (22.72°) compared to neat PVDF (93.1°) membrane. Ultimately the membrane used for indigo carmine (IC) adsorption and an enhanced removal efficiency (88.9%) and adsorption capacity (72.6mgg-1) were observed compared to neat PVDF. In the future, the overall idea can make leads to various applications such as proteins, virus and hormones adsorption from the contaminated sources.