RESUMEN
The prospective studies included 178 patients (43 men and 135 women) aged 30 to 68 years, treated because of rheumatoid arthritis (R.A.). All of them were subjected to systemic cryotherapy, considerin the total antioxidant states in the serum registered before and after the cryotherapic treatment. Fluctuations of serum antioxidants were referred to selected clinical factors such as: sex, age, duration and progression of the disease. It was confirmed that among patients with R.A., the most beneficial clinical effects obtained through systemic cryotherapy may be expected in women aged up to 49 years, in whom the disease lasted no longer than 3 years and is in the Ist of IInd period (phase).
Asunto(s)
Artritis Reumatoide/rehabilitación , Crioterapia , Adulto , Factores de Edad , Anciano , Antioxidantes/metabolismo , Artritis Reumatoide/sangre , Progresión de la Enfermedad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores Sexuales , Resultado del TratamientoRESUMEN
In the present study, we investigated the relationship between depressive symptoms and serum zinc and magnesium level in antepartum and postpartum women. All women received standard vitamin, zinc and magnesium supplementation. Sixty-six pregnant women in the Czerwiakowski Hospital in Kraków were assessed for prepartum depressive symptoms using the Beck Depression Inventory (BDI). Sixty-two and fifty-eight women were also assessed for postpartum depressive symptoms (using Edinburgh Postnatal Depression Rating Scale, EPDRS) at 3 and 30 days after delivery, respectively. Serum zinc and magnesium levels were also determined at these time points, however, the number of examined subjects were diminished. A significantly higher EPDRS score (by 45%), indicating severity of depressive symptoms, was found on the 3rd day after childbirth compared with the 30th postpartum day. Moreover, the early post-delivery period (3rd day) was characterized by a 24% lower serum zinc concentration than that found on the 30th day after childbirth. BDI scores assessed a month before childbirth revealed mild depressive symptoms, which was accompanied by a serum zinc concentration similar to that found on the 3rd day after delivery. No significant alterations were found in the magnesium levels between these time points. The present results demonstrated a relationship between severity of depressive symptoms and decreased serum zinc (but not magnesium) concentration in a very specific type of affective disorder, the postpartum depression.
Asunto(s)
Depresión Posparto/sangre , Depresión/sangre , Compuestos de Magnesio/sangre , Complicaciones del Embarazo/sangre , Compuestos de Zinc/sangre , Adulto , Depresión/psicología , Depresión Posparto/psicología , Femenino , Humanos , Embarazo , Complicaciones del Embarazo/psicología , Escalas de Valoración Psiquiátrica , Índice de Severidad de la Enfermedad , Factores de TiempoRESUMEN
Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression. Therefore, we studied the effect of classic antidepressant drug imipramine (10 mg/kg ip) on activity of this enzyme in plasma of rats subjected to chronic mild stress (CMS), the model of anhedonia. CMS induced reductions in DBH activity by the second day and 5th week of stress duration. Imipramine treatment minimized these CMS-induced reductions. The data indicate that, similarly to human depression, CMS also affects DBH activity, and, moreover, the CMS-induced alterations are normalized by imipramine treatment.